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The Major Y-Chromosome Haplogroup R1b-M269 in West-Europe, Subdivided by the Three SNPs S21/U106, S145/L21 and S28/U152, Shows a Clear Pattern of Geographic Differentiation
Institute of Molecular Anthropology, Paris, France
- 1 Institute of Molecular Anthropology, Paris, France
Advances in Anthropology·Volume 05 (2015)·Pages 22–30·Published 2 February 2015·DOI10.4236/aa.2015.51003
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Abstract
More than 2600 unrelated males from West-Europe were analysed by molecular hybridization experiments for the p49a,fTaq I polymorphisms. A total of 895 subjects (34%), belonging to haplogroup M269, were identified and further analysed for the three SNPs, S21/U106, S145/L21 and S28/U152; these three SNPs define the Northwest, West and South European sub-haplogroups, respectively. These haplogroups showed quite different frequency distribution patterns within West-Europe, with frequency peaks in Northern Europe, in Brittany in France and in Northern Italy/Southern France.
KeywordsY-Chromosome DNA PolymorphismsHaplogroupsSNPWest-EuropeSub-Haplogroups
- Busby, G. B. J., Brisghelli, F., Sánchez-Diz, P., Ramos-Luis, E., Martinez-Cadenas, C., et al. (2013). The Peopling of Europe and the Cautionary Tale of Y-Chromosome Lineage R-M269. Proceedings of the Royal Society B, 269, 884-892.
- Cruciani, F., Trombetta, B., Antonelli, C., Pascone, R., Valesini, G., et al. (2011). Strong Intra- and Inter-Continental Differentiation Revealed by Y Chromosome SNPs M269, U106 and U152. Forensic Science International: Genetics, 5, e49-e52. http://dx.doi.org/10.1016/j.fsigen.2010.07.006
- Diéterlen, F., & Lucotte, G. (2005). Haplotype XV of the Y-Chromosome Is the Main Haplotype in West-Europe. Biomedecine and Pharmacotherapy, 59, 269-272. http://dx.doi.org/10.1016/j.biopha.2004.08.023
- Gautreau, C., Rahuel, C., Cartron, J. P., & Lucotte, G. (1983). Comparison of Two Methods of High Molecular Weight DNA Isolation from Human Leucocytes. Analytical Biochemistry, 134, 320-324. http://dx.doi.org/10.1016/0003-2697(83)90304-4
- Klyosov, A. A. (2012). Ancient History of Arbins, Bearers of Haplogroup R1b, from Central Asia to Europe, 16,000 to 150 Years before Present. Advances in Anthropology, 2, 87-105. http://dx.doi.org/10.4236/aa.2012.22010
- Lucotte, G., & Ngo, K. Y. (1985). A Highly Polymorphic Probe That Detects Taq I RFLPs on the Human Y-Chromosome. Nucleic Acids Research, 13, 8285. http://dx.doi.org/10.1093/nar/13.22.8285
- Lucotte, G., Gérard, N., Krichnamoorthy, R., David, F., Aouizérate, A., & Galzot, P. (1994). Reduced Variability in Y-Chromosome Specific Haplotypes from Some Central African Populations. Human Biology, 66, 519-526.
- Lucotte, G., & Hazout, S. (1996). Y-Chromosome DNA Haplotypes in Basques. Journal of Molecular Evolution, 42, 472- 475. http://dx.doi.org/10.1007/BF02498642
- Lucotte, G., & Loirat, F. (1999). Y-Chromosome DNA Haplotype XV in Europe. Human Biology, 42, 472-475.
- Malaspina, P., Cruciani, F., Santolamazza, P., Torroni, A., Pangrazio, A., et al. (2000). Patterns of Male-Specific Inter- Population Divergence in Europe, West Asia and North Africa. Annals of Human Genetics, 64, 395-412. http://dx.doi.org/10.1046/j.1469-1809.2000.6450395.x
- Morelli, L., Contu, D., Santoni, F., Whalen, M. B., Francalacci, P., & Cucca, F. (2010). A Comparison of Y-Chromosome Variation in Sardinia and Anatolia Is More Consistent with Cultural Rather than Demic Diffusion of Agriculture. PLoS One, 5, e10419. http://dx.doi.org/10.1371/journal.pone.0010419