Innovation in the University-Industry-Research Collaboration Paradigm: A Case Study of the Immunology Frontier Research Center of Osaka University — Oak Academic Publishing
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Innovation in the University-Industry-Research Collaboration Paradigm: A Case Study of the Immunology Frontier Research Center of Osaka University
School of Education, Soochow University, Suzhou, China
1 School of Education, Soochow University, Suzhou, China
By systematically examining the practical dilemmas confronting the traditional Industry-University-Research (IUR) collaboration model in terms of contractual mechanisms, achievement commercialization, and benefit distribution, this study focuses on the new IUR collaborative innovation paradigm constructed by the Immunology Frontier Research Center (IFReC) of Osaka University, which is driven by the concept of “co-creation”. Through a multi-dimensional analysis of IFReC’s groundbreaking practices in the initial collaboration stage, funding models, and contractual mechanisms, this study aims to extract its successful experience, explore its enlightenment for Chinese universities to deepen IUR collaboration, and provide a reference with both theoretical depth and practical value for promoting the innovation of the IUR collaboration paradigm.
KeywordsIndustry-University-Research CollaborationBasic ResearchImmunology Frontier Research CenterWorld Premier International Research Center Initiative
Azoulay, P., Ding, W., & Stuart, T. (2009). The Impact of Academic Patenting on the Rate, Quality and Direction of (Public) Research Output. The Journal of Industrial Economics, 57, 637-676. https://doi.org/10.1111/j.1467-6451.2009.00395.x
Cabinet Office, Government of Japan (2019). The 1st Japan Open Innovation Prize . (In Japanese) https://www8.cao.go.jp/cstp/openinnovation/prize/joipichiran.pdf
Center for Co-Creation, Osaka University (n.d.). A Quick Guide to Collaboration Types . (In Japanese) https://www.ccb.osaka-u.ac.jp/service/hitome/
Chen, J. (2025). Accelerating the Development of New Quality Productive Forces Requires Strengthening Capabilities for Original Innovation and Disruptive Innovation. People’s Tribune, 24, 6-9.
Chen, K. Y., Kibayashi, T., Giguelay, A., Hata, M., Nakajima, S., Mikami, N. et al. (2025). Genome-Wide CRISPR Screen in Human T Cells Reveals Regulators of FOXP3. Nature , 642, 191-200. https://doi.org/10.1038/s41586-025-08795-5
Chugai Pharmaceutical (2025). Chugai and IFReC: Pioneering Next-Generation Immunology Therapies through Open Innovation . (In Japanese) https://www.chugai-pharm.co.jp/english/story/detail/20251007000000_90.html
Chugai Pharmaceutical Co., Ltd (2016). Announcement on Conclusion of Comprehensive Collaboration Agreement between Osaka University and Chugai Pharmaceutical . (In Japanese) https://www.chugai-pharm.co.jp/news/detail/20160519150000_180.html
Chugai Pharmaceutical Co., Ltd (n.d.). What Kind of Company Is Chugai? https://www.chugai-pharm.co.jp/english/profile/overview/whatkind/
Council for Science and Technology Policy, Cabinet Office, Government of Japan (2009). Third Science and Technology Basic Plan Follow-Up . Council for Science and Technology Policy, Government of Japan.
Digital Science & Research Solutions Ltd. (2021). Scientific and Social Impact of the World Premier International Research Center Initiative . Digital Science & Research Solutions Ltd.
Gao, L. M., & Ma, W. J. (2014). Open Innovation: Connotation, Framework and Chinese Context. Management World, 6, 157-169. (in Chinese) https://doi.org/10.19744/j.cnki.11-1235/f.2014.06.013
Gu, J. F. (2023). Commercialization of Academic Patents in Chinese Universities: Antecedents and Spatial Spillovers. Heliyon, 9, e14601. https://doi.org/10.1016/j.heliyon.2023.e14601
He, J. (2023). “Repositioning” Is More Important Than “Connecting”: Reflections on the Policy of Science and Technology Achievement Transformation from a Holistic Perspective. Journal of Renmin University of China, 37, 118-130. https://kns.cnki.net/kcms2/article/abstract?v=A2Z-m-A1gckmKfYQK5MfRfafCc02cyrzDyx2vubbgEMOama0O0_k7BKo82YVjzfFGR-aOlggHpIXpmfnLXvRS_TxdP7a3qPujt-5B2Ufoq39VYTzyVe5wk9WzLyZPBB7BPjugl6kYqrR2VTuuVFJqlTh5rPxJgUcIu3SaYNFBvGgdFq1bRQGjQ==&uniplatform=NZKPT&language=CHS
Ichiko, F. (2018). Osaka Hastens Industry Partnerships. Nature Index . https://www.nature.com/nature-index/news/osaka-hastens-industry-partnerships
Immunology Frontier Research Center, Osaka University (2017). Announcement on Conclusion of Comprehensive Collaboration Agreement between Osaka University and Otsuka Pharmaceutical . (In Japanese) https://www.ifrec.osaka-u.ac.jp/jpn/topics/20170216-0200.htm
Japan Society for the Promotion of Science (JSPS) (2025). World Premier International Research Center Initiative (WPI): Program Overview. https://www.jsps.go.jp/english/e-toplevel/11_gaiyo.html
Japan Society for the Promotion of Science (JSPS) (2025). World Premier International Research Center Initiative (WPI): Selected Projects. https://www.jsps.go.jp/english/e-toplevel/04_centers.html
Japan Society for the Promotion of Science (n.d.). World Premier International Research Center Initiative (WPI) . (In Japanese) https://www.jsps.go.jp/j-toplevel/04_saitaku.html
Kuwashima, K. (2020). A Role Model of Large-Scale University-Industry Collaboration in Japan: The Case of Chugai Pharmaceutical and Osaka University. Annals of Business Administrative Science, 19, 81-96. https://doi.org/10.7880/abas.0200422a
Lei, C. Z. (2023). Strengthening the Enterprise-Led Deep Integration of Industry-University-Research to Promote High-Quality Development of University Scientific and Technological Innovation. Journal of National Academy of Education Administration, 6, 3-5. https://kns.cnki.net/kcms2/article/abstract?v=A2Z-m-A1gcmGxrwIoN6cWRxGBm-WbmEKRS8jTgOvNVeAvjzs71hfBYh23J4tDNWZJmRG1VMzVeAOFQx9fAUXMBWqLqFFlSjyJMpvgQ7kY3uLxaD-dkK1IbFrnrHsUsreKV1o_apZ92ChgMPl2VQvE0GGLTOPqOJiOc1Gzp0O7XFGm7vKPHPwsA==&uniplatform=NZKPT&language=CHS
Ma, W. J., & Gao, L. M. (2016). Research on the Relationship between Openness and Innovation Performance: The Moderating Role of Dynamic Capabilities. Science Research Management, 37, 47-54. (in Chinese) https://doi.org/10.19571/j.cnki.1000-2995.2016.02.006
Ma, X. F., & Du, Z. W. (2022). The Impact of Institutional and Cooperative Environments on Enterprise Open Innovation Paths: A Fuzzy-Set Qualitative Comparative Analysis of 26 Enterprises from China and the United States. Science & Technology Progress and Policy, 39, 71-80. https://kns.cnki.net/kcms2/article/abstract?v=A2Z-m-A1gckzGU8oXZAkOpOkQvgvdRsH9nit_1QaKcb6UfdAG3J4kxfY7NAusTHRTnDYQF_1cR4ROIUov4z_aDancgK-2tqn2Wb5p3VRaVPdjVthRTfnc-bZIeTBm9yTg8gjOsVptWy8v0ZTCcGUjtKzVZpctmkLcaXs7razouFP67rTMVpLhA==&uniplatform=NZKPT&language=CHS
Ministry of Education, Culture, Sports, Science and Technology (2018). Status of Industry-University Collaboration at Universities, Etc., Fiscal 2016 . https://www.mext.go.jp/a_menu/shinkou/sangaku/1397873.htm
Ministry of Education, Culture, Sports, Science and Technology (MEXT) (2025). FY 2025 Follow-Up of WPI Program. https://www.jsps.go.jp/file/storage/e-toplevel_08_followup/report/FY2025_FU_Report_E.pdf
Mixonline (2025). Osamu Okuda, CEO of Chugai Pharmaceutical, Comments on Comprehensive Collaboration with IFReC. Mixonline. https://www.mixonline.jp/tabid55.html?artid=79083
Peng, D., Li, J., Qiu, Z. Y., & Liu, H. Y. (2026). The Impact of Interdisciplinary Scientific Collaboration on the Ambidextrous Innovation of Specialized and Sophisticated “Little Giant” Enterprises. Science & Technology Progress and Policy, 43, 90-99. https://kns.cnki.net/kcms2/article/abstract?v=A2Z-m-A1gcmvtXUemfMDmp3D3ElizMYOx0i68erOV0laMUu6s8hrK75sYfnFjMZXD2-7_py6-CpKeNKCEH5xqQELuAYWNFZQ6Qqs10ZAHQ8b9g2K6lcbAOn09sWbaLOiy8xPfZ0xelmrx1jpZYdr_jGSCo-FxTazVK12bqIkxQmd6oA9CkRfmQ==&uniplatform=NZKPT&language=CHS
Qian, L. X., & Chen, J. (2022). A Review of Open Innovation Research: Theoretical Framework, Research Directions and Chinese Context. Review of Evolutionary Economics and Economics of Innovation, 1, 82-99. https://kns.cnki.net/kcms2/article/abstract?v=A2Z-m-A1gcliD5zj-PqPf1q_wDrfvY6QZ0uo-sIOgyMIoSaZK4y8yhTZg3B0Cu74i9ab6Xw1aiHtmW4Cag-EjCUyzMgb4-UeoRWkc-fkeIpMpDUs8X_KOjj0hzPY8xfORiIVjPzq9H58HPswlyZh66d9OstTXTHpCoIuBWmBZKBZHSaq5AeGSA==&uniplatform=NZKPT&language=CHS
Shi, Y., Li, J. Y. H., Wang, G. S., Bai, S. R., Bian, G. B., & Li, B. Q. (2021). Constructing a Basic Research Funding Navigation System Platform to Promote Technological Innovation and Support the Development of a Modern Industrial System. Bulletin of Chinese Academy of Sciences, 36, 573-579. (in Chinese) https://doi.org/10.16418/j.issn.1000-3045.20210407007
Takagi, A. (2021). Promotion of New Industry-Academia Collaboration and Human Immunology Research at the Immunology Frontier Research Center, Osaka University. MedChem News, 31, 111-115.
Zhang, J., & Bai, K. R. (2022). Basic Research in Chinese Universities and Enterprise Innovation. Economic Research Journal, 57, 124-142. https://kns.cnki.net/kcms2/article/abstract?v=A2Z-m-A1gcnF7Mcg6oRRBdJTB9ibVroVq8jeQU0JC-f8D1nUES4Jwy8rcZRmVcKdLdbfqNHtQu5tBgbP58iUaEtpIO6pGvV8W5kqdz_A08Ad0VXA6k-w0LIzoXTWQzQHDKxo39arXeL_e4rttHTbexLpJXDwLvavQQwgihRWgro8KUuPkT7oGw==&uniplatform=NZKPT&language=CHS
Zhang, Y. F., Liu, B., Yuan, C. H., & Zhang, S. M. (2025). Research on the Construction Path of Industry-University-Research Innovation Consortia under the Scenario of Chinese Modernization. Science Research Management, 46, 73-85. (in Chinese) https://doi.org/10.19571/j.cnki.1000-2995.2025.02.008