Structure and properties of bone-like-nanohydroxyapatite/gelatin/polyvinyl alcohol composites
- 1
- 2
- 3
- 4
- 5
Abstract
Bone-like nanohydroxyapatite powders (b-nanoHA) were synthesized in simulated body fluid (SBF). The b-nanoHA, gelatin (Gel) and Polyvinyl Alcohol (PVA) were used to prepare bone-like composites (b-nanoHA/ Gel/PVA) at room temperature. Characterizations of b-nanoHA powders and b-nanoHA/Gel/PVA composites were investigated by using X-ray diffraction (XRD), transmission electron microscopy (TEM), High-resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). Bending strength and compressive strength of the composite were tested. It was found that microstructure of the b-nanoHA powders was whisker shape and its crystalline degree was low similar to natural bone, bending strength and compressive strength of the b-nanoHA/Gel/PVA composite depended on the mixing ratio of HA, Gel and PVA, and also PVA could induce the network formation in the b-nanoHA/Gel/ PVA composite.
- Hench, L.L. (1991) Bioceramics: From concept to clinic. Journal of America Ceramic Society, 74(7), 1487-1510.
- Larry, L.H. (1998) Biomaterials: A forecast for the future. Biomaterials, 19(16), 1419-1423.
- Koutsopoulos, S. (2002) Synthesis and characterization of hydroxyapatite crystals: A review study on the analy- tical methods. Journal of Biomedical Materials Research, 62(4), 600-612.
- Weiner, S. and PRICE, P. (1986) Disaggregation of bone into crystals. Calcified Tissue International, 39(5), 365- 375.
- Salyer, K.E. and Hall, C.D. (1989) Porous hydroxya- patite as an only bone graft substitute for maxillofocid surgery. Plast Reconstructive Surgery, 84, 236-244.
- Bako?, D., Soldán, M. and Hernández-Fuentes, I. (1999) Hydroxyapatite-collagen-hyaluronic acid composite. Bio- materials, 20(2), 191-195.
- Chang, M.C., Ko, C.C and Douglas W.H. (2003) Preparation of hydroxyapatite-gelatin nanocomposite. Biomaterials, 24(17), 2853-2862.
- Chang, M.C. and Douglas, W.H. (2007) Cross-linkage of hydroxyapatite/gelatin nanocomposite using imide-based zero-length cross-linker. Journal of Materials Science: Materials in Medicine, 18(10), 2045-2051.
- Chang, M.C. (2008) Organic-inorganic interaction between hydroxyapatite and gelatin with the aging of gelatin in aqueous phosphoric acid solution. Journal of Materials Science: Materials in Medicine, 19(11), 3411- 3418.
- Fratzl, P., Groschner, M., Vogl, G., Plenk, H., Jr, Esch- berger, J., Fratzl-zelman, N., Koller, K. and Klaushofer, K. (1992) Mineral crystals in calcified tissues—a compa- rative study by SAXS. Journal of Bone Mineral Re- search, 7(3), 329-334.
- Su, X., Sun, K., Cui, F.Z. and Landis, W.J. (2003) Organization of apatite crystals in human woven bone. Bone, 32(2), 150-162.
- Lin, X.Y., Li, X.D., Fan, H.S., Xiao, Y.M., Lu, J. and Zhang X.D. (2005) Comparative investigation of copre -cipitation and in-situ synthesis of nanohydroxyapatite/ collagen composite. Key Engineering Materials, 284-286, 839-842.
- Charulatha, V. and Rajaram, A. (2003) Influence of diff- erent crosslinking treatments on the physical properties of collagen membranes. Biomaterials, 24(5), 759-767.
- Gilberto, G., Elcio, M., Rosemary, A.C.M., Rafael, C.C.L., Daniela, C.J.C. and Wanda, Maria de C. (1999) Biocompatibility studies of anionic collagen membranes with different degree of glutaraldehyde cross-linking. Biomaterials, 20(1), 27-34.