Body temperature control in fever modeling after preliminary injection of glutamate receptors ligands into the solitary tract nucleus — Oak Academic Publishing
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Body temperature control in fever modeling after preliminary injection of glutamate receptors ligands into the solitary tract nucleus
Institute of Physiology of NAS of Belarus, Minsk, Belarus
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Institute of Physiology of NAS of Belarus, Minsk, Belarus
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Institute of Physiology of NAS of Belarus, Minsk, Belarus
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The National Centre for Scientific Research, Joint Research Unit 6214 - The French National Institute of Health and Medical Research, Joint Research Unit 1083
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Institute of Physiology of NAS of Belarus, Minsk, Belarus
1 Institute of Physiology of NAS of Belarus, Minsk, Belarus
2 Institute of Physiology of NAS of Belarus, Minsk, Belarus
3 Institute of Physiology of NAS of Belarus, Minsk, Belarus
4 The National Centre for Scientific Research, Joint Research Unit 6214 - The French National Institute of Health and Medical Research, Joint Research Unit 1083
5 Institute of Physiology of NAS of Belarus, Minsk, Belarus
Deep body temperature of 57 male Wistar rats was measured in response to systemic (i.v. or i.p.) injec tion of Escherichia coli lipopolysaccharide (LPS). Ani mals were preliminarily (4 weeks before the experiment) treated with microinjections of the toxic dose of glutamate receptors agonists or vehicle into solitary tract nucleus or caudal part of ventrolateral medulla. Microinjections of the glutamate receptors agonists provoked a local destruction of brain tissue, which was accompanied by the significant transformation (amplification or attenuation) of temperature response to the systemic injection of 3 μg/kg E. coli LPS. Animals treated with vehicle did not demonstrate significant changes in their response to LPS. Obtained data testify that impairment of central nervous struc ture involved in the regulation and maintenance of deep body temperature is accompanied by atypical development of E. coli LPS-induced fever.
Keywords<i>Escherichia coli</i>EndotoxinBrainstemFeverControl Body TemperatureDefense Reflexes
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