Sex effect on presenilins expression in post-natal rat brain — Oak Academic Publishing
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Sex effect on presenilins expression in post-natal rat brain
Department of Cellular Biology and Neuroscience, Section of Clinics, Diagnosis and Therapy of Central Nervous System Diseases, Istituto Superiore di Sanità, Rome, Italy
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Department of Psychology, Section of Neuroscience, “Sapienza” University of Rome, Rome, Italy
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Department of Cellular Biology and Neuroscience, Section of Clinics, Diagnosis and Therapy of Central Nervous System Diseases, Istituto Superiore di Sanità, Rome, Italy; Department of Psychology, Section of Neuroscience, “Sapienza” University of Rome, Rome, Italy
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Department of Cellular Biology and Neuroscience, Section of Clinics, Diagnosis and Therapy of Central Nervous System Diseases, Istituto Superiore di Sanità, Rome, Italy
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Department of Cellular Biology and Neuroscience, Section of Clinics, Diagnosis and Therapy of Central Nervous System Diseases, Istituto Superiore di Sanità, Rome, Italy
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Department of Psychology, Section of Neuroscience, “Sapienza” University of Rome, Rome, Italy
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Department of Cellular Biology and Neuroscience, Section of Clinics, Diagnosis and Therapy of Central Nervous System Diseases, Istituto Superiore di Sanità, Rome, Italy
1 Department of Cellular Biology and Neuroscience, Section of Clinics, Diagnosis and Therapy of Central Nervous System Diseases, Istituto Superiore di Sanità, Rome, Italy
2 Department of Psychology, Section of Neuroscience, “Sapienza” University of Rome, Rome, Italy
3 Department of Cellular Biology and Neuroscience, Section of Clinics, Diagnosis and Therapy of Central Nervous System Diseases, Istituto Superiore di Sanità, Rome, Italy; Department of Psychology, Section of Neuroscience, “Sapienza” University of Rome, Rome, Italy
4 Department of Cellular Biology and Neuroscience, Section of Clinics, Diagnosis and Therapy of Central Nervous System Diseases, Istituto Superiore di Sanità, Rome, Italy
5 Department of Cellular Biology and Neuroscience, Section of Clinics, Diagnosis and Therapy of Central Nervous System Diseases, Istituto Superiore di Sanità, Rome, Italy
6 Department of Psychology, Section of Neuroscience, “Sapienza” University of Rome, Rome, Italy
7 Department of Cellular Biology and Neuroscience, Section of Clinics, Diagnosis and Therapy of Central Nervous System Diseases, Istituto Superiore di Sanità, Rome, Italy
Presenilin 1 and presenilin 2 are widely expressed during brain development. Several mutations in these proteins have been associated with autosomal-dominant inherited forms of Alzheimer disease. Their expression is regulated by various cellular and extracellular factors, which change with age and sex. Both age and sex are key risk factors for Alzheimer’s disease, but the issue of whether the expression of presenilins is influenced by the sex during early postnatal development of the brain has been poorly investigated so far. In this study, we report that transcript levels of presenilins, and the subset of neurons expressing these proteins in various brain areas of the developing post-natal brain are different in male and female rats, suggesting that their function(s) may contribute to sexual dimorphism in the brain, both at morphological and functional levels.
Wolfe, M.S. (2006) The gamma-secretase complex: Membrane-embedded proteolytic ensemble. Biochemistry, 45, 7931-7939. http://dx.doi.org/10.1021/bi060799c
Hutton, M. and Hardy, J. (1997) The presenilins and Alzheimer’s disease. Human Molecular Genetics, 6, 1639-1646. http://dx.doi.org/10.1093/hmg/6.10.1639
Selkoe, D. and Kopan, R. (2003) Notch and presenilin: Regulated intramembrane proteolysis links development and degeneration. Annual Review of Neuroscience, 26, 565-597. http://dx.doi.org/10.1146/annurev.neuro.26.041002.131334
Berezovska, O., Xia, M.Q., Page, K., Wasco, W., Tanzi, R.E. and Hyman, B.T. (1997) Developmental regulation of presenilin mRNA expression parallels notch expression. Journal of Neuropathology & Experimental Neurology, 56, 40-44. http://dx.doi.org/10.1097/00005072-199701000-00004
Song, W., Nadeau, P., Yuan, M., Yang, X., Shen, J. and Yankner, B.A. (1999) Proteolytic release and nuclear translocation of notch-1 are induced by presenilin 1 and impaired by pathogenic presenilin 1 mutations. Proceedings of the National Academy of Sciences of the United States of America, 96, 6959-6963. http://dx.doi.org/10.1073/pnas.96.12.6959
Shen, J., Branson, R.T., Chen, D.F., Xia, W., Selkoe, D.J. and Tonegawa, S. (1997) Skeletal and CNS deficits in presenilin 1-deficient mice. Cell, 89, 629-639. http://dx.doi.org/10.1016/S0092-8674(00)80244-5
Conlon, R.A., Reaume, A.G. and Rossant, J. (1995) Notch1 is required for the coordinate segmentation of somites. Development, 121, 1533-1545.
Lee, M.K., Slunt, H.H., Martin, L.J., Thinakaran, G., Kim, G., Gandy, S.E., Seeger, M., Koo, E., Price, D.L. and Sisodia S. (1996) Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. The Journal of Neuroscience, 16, 7513-7525.
Moreno-Flores, M.T., Medina, M. and Wandosell, F. (1999) Expression of presenilin 1 in nervous system during rat development. Journal of Comparative Neurology, 410, 556-570. http://dx.doi.org/10.1002/(SICI)1096-9861(19990809)410:4 3.0.CO;2-Q
Kumar, A. and Thakur, M.K. (2012) Presenilin 1 and 2 are expressed differentially in the cerebral cortex of mice during development. Neurochemistry International, 61, 778-782. http://dx.doi.org/10.1016/j.neuint.2012.07.001
Kang, D.E., Yoon, I.S., Repetto, E., Busse, T., Yermian, N., Ie, L. and Koo, E.H. (2005) Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. The Journal of Biological Chemistry, 280, 31537-31547. http://dx.doi.org/10.1074/jbc.M500833200
Satoh, J. and Kuroda, Y. (1999) Constitutive and cytokine-regulated expression of presenilin-1 and presenilin-2 genes in human neural cell lines. Neuropathology and Applied Neurobiology, 25, 492-503. http://dx.doi.org/10.1046/j.1365-2990.1999.00209.x
Ghosh, S. and Thakur, M.K. (2008) PS1 expression is downregulated by gonadal steroids in adult mouse brain. Neurochemical Research, 33, 365-369. http://dx.doi.org/10.1007/s11064-007-9424-8
Ghosh, S. and Thakur, M.K. (2008) PS2 protein expression is upregulated by sex steroids in the cerebral cortex of aging mice. Neurochemistry International, 52, 363-367. http://dx.doi.org/10.1016/j.neuint.2007.07.015
Bowen, R.L., Verdile, G., Liu, T., Parlow, A.F., Perry, G., Smith, M.A., Martins, R.N. and Atwood, C.S. (2004) Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition. The Journal of Biological Chemistry, 279, 20539-20545. http://dx.doi.org/10.1074/jbc.M311993200
Placanica, L., Zhu, L. and Li, Y.M. (2009) Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. PLoS One, 4, e5088. http://dx.doi.org/10.1371/journal.pone.0005088
Gallagher, J.J., Minogue, A.M. and Lynch, M.A. (2013) Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased Aβ accumulation and microglial activation. Neurodegenerative Diseases, 11, 33-41. http://dx.doi.org/10.1159/000337458
Thakur, M.K. and Ghosh, S. (2007) Age and sex dependent alteration in presenilin expression in mouse cerebral cortex. Cellular and Molecular Neurobiology, 27, 1059-1067. http://dx.doi.org/10.1007/s10571-007-9214-5
European Economic Community (1986) European Council Directive 86/609/EEC on the approximation of laws, regulations and administrative provisions of the member states regarding the protection of animals used for experimental and other scientific. http://eurlex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:31986L0609:EN:HTM
Piscopo, P., Bernardo, A., Calamandrei, G., Venerosi, A., Valanzano, A., Bianchi, D., Confaloni, A. and Minghetti, L. (2008a) Altered expression of cyclooxygenase-2, presenilins and oxygen radical scavenging enzymes in a rat model of global perinatal asphyxia. Experimental Neurology, 209, 192-198. http://dx.doi.org/10.1007/s10571-007-9214-5
Piscopo, P., Marcon, G., Piras, M.R, Crestini, A, Malvezzi Campeggi L., Deiana E., Cherchi R., Tanda F., Deplano A., Vanacore N., Tagliavini F., Pocchiari M., Giaccone G. and Confaloni A.. (2008b) A novel PSEN2 mutation associated with a peculiar phenotype. Neurology, 70, 1549-1554. http://dx.doi.org/10.1212/01.wnl.0000310643.53587.87
Piscopo, P., Talarico, G., Crestini, A., Gasparini, M., Malvezzi-Campeggi, L., Piacentini, E., Lenzi, G. L., Bruno, G. and Confaloni, A. (2010) A novel mutation in the predicted TM3 domain of the PSEN2 gene in an Italian pedigree with a typical Alzheimer’s disease. Journal of Alzheimer’s Disease, 20, 43-47.
Andersen, K., Launer, L.J., Dewey M.E., Letenneur, L., Ott, A., Copeland, J.R., Dartigues, J.F., Kragh-Sorensen, P, Baldereschi, M., Brayne, C., Lobo, A., Martinez-Lage, J.M., Stijnen, T., Hofman, A. and EURODEM Incidence Research Group (1999) Gender differences in the incidence of AD and vascular dementia: The EURODEM studies. Neurology, 53, 1992-1997. http://dx.doi.org/10.1212/WNL.53.9.1992
Fratiglioni, L., Viitanen, M., von Strauss, E., Tontodonati, V., Herlitz, A. and Winblad, B. (1997). Very old women at highest risk of dementia and Alzheimer’s disease: Incidence data from the Kungsholmen Project, Stockholm. Neurology, 48, 132-138. http://dx.doi.org/10.1212/WNL.48.1.132
Mani, S.T. and Thakur M.K. (2006) In the cerebral cortex of female and male mice, amyloid precursor protein (APP) promoter methylation is higher in females and differentially regulated by sex steroids. Brain Research, 1067, 43-47. http://dx.doi.org/10.1016/j.brainres.2005.10.006
Drummond, E.S., Martins, R.N., Handelsman, D.J. and Harvey, A.R. (2012) Altered expression of Alzheimer’s disease-related proteins in male hypogonadal mice. Endocrinology, 153, 2789-2799. http://dx.doi.org/10.1210/en.2011-2003
Cooke, G.M., Price, C.A. and Oko, R.J. (1998) Effects of in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on serum androgens and steroidogenic enzyme activities in the male rat reproductive tract. The Journal of Steroid Biochemistry and Molecular Biology, 67, 347-54. http://dx.doi.org/10.1016/S0960-0760(98)00127-7
Metzger, E., Wissmann, M., Yin, N., Müller, J.M., Schneider, R., Peters, A.H., Günther, T., Buettner, R. and Schüle, R. (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature, 437, 436-439.
Xu, J., Deng, X., Watkins, R. and Disteche, C.M. (2008) Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons. The Journal of Neuroscience, 28, 4521-4527. http://dx.doi.org/10.1523/JNEUROSCI.5382-07.2008
Yang, X., Schadt, E.E., Wang, S., Wang, H., Arnold, A.P., Ingram-Drake, L., Drake, T.A. and Lusis, A.J. (2006) Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Research, 16, 995-1004. http://dx.doi.org/10.1101/gr.5217506
Kristofiková, Z., Rícny, J., Kozmiková, I., Rípová, D., Zach, P. and Klaschka, J. (2006) Sex-dependent actions of amyloid beta peptides on hippocampal choline carriers of postnatal rats. Neurochemical Research, 31, 351-360.
Kodam, A., Vetrivel, K.S., Thinakaran, G. and Kar, S. (2008). Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains. Neurobiology of Aging, 29, 724-738. http://dx.doi.org/10.1016/j.neurobiolaging.2006.12.005
Kolb, B. and Stewart, J. (1991) Sex-related differences in dendritic branching of cells in the prefrontal cortex of rats. Journal of Neuroendocrinology, 3, 95-99. http://dx.doi.org/10.1111/j.1365-2826.1991.tb00245.x
Sotelo, C. (2004) Cellular and genetic regulation of the development of the cerebellar system. Progress in Neurobiology, 72, 295-339. http://dx.doi.org/10.1016/j.pneurobio.2004.03.004