Cardiovascular disease is one of many reverberating ailments that affect and kill hundreds of thousands of people around the world. To date treatments that offer improvement in the health condition of diseased people include the most promising nanomedicine although it is in its infancy, yet attaining attention from researchers of top notch day by day. In this current review importance is given on the application of nanomedicine in the diagnosis as well as treatment of cardiovascular disease.
Kim, B.Y.S., Rutka, J.T. and Chan, W.C.W. (2010) Nanomedicine. New England Journal of Medicine, 363, 2434-2443. http://dx.doi.org/10.1056/NEJMra0912273
Bharali, D.J. and Mousa, S.A. (2010) Emerging Nanomedicines for Early Cancer Detection and Improved Treatment: Current Perspective and Future Promise. Pharmacology & Therapeutics, 128, 324-335. http://dx.doi.org/10.1016/j.pharmthera.2010.07.007
Sajja, H.K., East, M.P., Mao, H., Wang, Y.A., Nie, S. and Yang, L. (2009) Development of Multifunctional Nanoparticles for Targeted Drug Delivery and Noninvasive Imaging of Therapeutic Effect. Current Drug Discovery Technologies, 6, 43-51. http://dx.doi.org/10.2174/157016309787581066
Ledet, G. and Mandal, T.K. (2012) Nanomedicine: Emerging Therapeutics for the 21st Century. U.S. Pharmacist, 37, 7-11.
Godin, B., Sakamoto, J.H., Serda, R.E., Grattoni, A., Bouamrani, A. and Ferrari, M. (2010) Emerging Applications of Nanomedicine for the Diagnosis and Treatment of Cardiovascular Diseases. Trends in Pharmacological Sciences, 31, 199-205. http://dx.doi.org/10.1016/j.tips.2010.01.003
Chhatriwalla, A.K. and Bhatt, D.L. (2008) Should Dual Anti-platelet Therapy after Drug-Eluting Stents Be Continued for More Than 1 Year? Circulation Cardiovascular Interventions, 1, 217-225. http://dx.doi.org/10.1161/CIRCINTERVENTIONS.108.811380
Galvin, P., Thompson, D., Ryan, K.B., McCarthy, A., Moore, A.C., Burke, C.S., et al. (2012) Nanoparticle-Based Drug Delivery: Case Studies for Cancer and Cardiovascular Applications. Cellular and Molecular Life Sciences, 69, 389-404. http://dx.doi.org/10.1007/s00018-011-0856-6
Bhaskar, S., Tian, F., Stoeger, T., Kreyling, W., de la Fuente, J.M., Grazú, V., et al. (2010) Multifunctional Nanocarriers for Diagnostics, Drug Delivery and Targeted Treatment Across Blood-Brain Barrier: Perspectives on Tracking and Neuroimaging. Particle and Fibre Toxicology, 7, 3. http://dx.doi.org/10.1186/1743-8977-7-3
World Health Organization (2011) Programmes and Projects: Global Atlas on Cardiovascular Disease Prevention and Control. World Health Organization, Geneva. http://www.who.int/cardiovascular_diseases/en/
Hoyert, D. and Xu, J. (2012) Deaths: Preliminary Data for 2011. National Vital Statistics Reports. National Center for Health Statistics, Hyattsville, 61, 1-65.
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J. and Thun, M.J. (2009) Cancer Statistics, 2009. CA: A Cancer Journal for Clinicians, 59, 225-249. http://dx.doi.org/10.3322/caac.20006
Riehemann, K., Schneider, S.W., Luger, T.A., Godin, B., Ferrari, M. and Fuchs, H. (2009) Nanomedicine—Challenge and Perspectives. Angewandte Chemie International Edition, 48, 872-897. http://dx.doi.org/10.1002/anie.200802585
Peer, D., Karp, J.M., Hong, S., Farokhzad, O.C., Margalit, R. and Langer, R. (2007) Nanocarriers as an Emerging Platform for Cancer Therapy. Nature Nanotechnology, 2, 751-760. http://dx.doi.org/10.1038/nnano.2007.387
Ferrari, M. (2008) Nanogeometry: Beyond Drug Delivery. Nature Nanotechnology, 3, 131-132. http://dx.doi.org/10.1038/nnano.2008.46
Ferrari, M. (2005) Cancer Nanotechnology: Opportunities and Challenges. Nature Reviews Cancer, 5, 161-171. http://dx.doi.org/10.1038/nrc1566
Smith, R.C. and McCarthy, S. (1992) Physics of Magnetic Resonance. Journal of Reproductive Medicine, 37, 19-26.
Sosnovik, D.E., Nahrendorf, M. and Weissleder, R. (2008) Magnetic Nanoparticles for MR Imaging: Agents, Techniques and Cardiovascular Applications. Basic Research in Cardiology, 103, 122-130. http://dx.doi.org/10.1007/s00395-008-0710-7
Pan, D., Senpan, A., Caruthers, S.D., Williams, T.A., Scott, M.J., Gaffney, P.J., et al. (2009) Sensitive and Efficient Detection of Thrombus with Fibrin-Specific Manganese Nanocolloids. Chemical Communications, 3234-3236. http://dx.doi.org/10.1039/b902875g
Michalet, X., Pinaud, F.F., Bentolila, L.A., Tsay, J.M., Doose, S., Li, J.J., et al. (2005) Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics. Science, 307, 538-544. http://dx.doi.org/10.1126/science.1104274
Serda, R.E., Godin, B., Tasciotti, E., Liu, X. and Ferrari, M. (2009) Mitotic Trafficking of Silicon Microparticles. Nanoscale, 1, 250-259. http://dx.doi.org/10.1039/b9nr00138g
Kooi, M.E., Cappendijk, V.C., Cleutjens, K.B., Kessels, A.G., Kitslaar, P.J., Borgers, M., et al. (2003) Accumulation of Ultrasmall Superparamagnetic Particles of Iron Oxide in Human Atherosclerotic Plaques Can Be Detected by in Vivo Magnetic Resonance Imaging. Circulation, 107, 2453-2458. http://dx.doi.org/10.1161/01.CIR.0000068315.98705.CC
Devaraj, N.K., Keliher, E.J., Thurber, G.M., Nahrendorf, M. and Weissleder, R. (2009) 18F Labeled Nanoparticles for in Vivo PET-CT Imaging. Bioconjugate Chemistry, 20, 397-401. http://dx.doi.org/10.1021/bc8004649
Nahrendorf, M., Zhang, H., Hembrador, S., Panizzi, P., Sosnovik, D.E., Aikawa, E., et al. (2008) Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis. Circulation, 117, 379-387. http://dx.doi.org/10.1161/CIRCULATIONAHA.107.741181
Chen, W., Vucic, E., Leupold, E., Mulder, W.J., Cormode, D.P., Briley-Saebo, K.C., et al. (2008) Incorporation of an apoE-Derived Lipopeptide in High-Density Lipoprotein MRI Contrast Agents for Enhanced Imaging of Macrophages in Atherosclerosis. Contrast Media & Molecular Imaging, 3, 233-242. http://dx.doi.org/10.1002/cmmi.257
Amirbekian, V., Lipinski, M.J., Briley-Saebo, K.C., Amirbekian, S., Aguinaldo, J.G., Weinreb, D.B., et al. (2007) Detecting and Assessing Macrophages in Vivo to Evaluate Atherosclerosis Noninvasively Using Molecular MRI. Proceedings of the National Academy of Sciences of the United States of America, 104, 961-966. http://dx.doi.org/10.1073/pnas.0606281104
Cyrus, T., Abendschein, D.R., Caruthers, S.D., Harris, T.D., Glattauer, V., Werkmeister, J.A., et al. (2006) MR Three-Dimensional Molecular Imaging of Intramural Biomarkers with Targeted Nanoparticles. Journal of Cardiovascular Magnetic Resonance, 8, 535-541. http://dx.doi.org/10.1080/10976640600580296
Botnar, R.M., Buecker, A., Wiethoff, A.J., Parsons Jr., E.C., Katoh, M., Katsimaglis, G., et al. (2004) In Vivo Magnetic Resonance Imaging of Coronary Thrombosis Using a Fibrin-Binding Molecular Magnetic Resonance Contrast Agent. Circulation, 110, 1463-1466. http://dx.doi.org/10.1161/01.CIR.0000134960.31304.87
Lanza, G.M., Trousil, R.L., Wallace, K.D., Rose, J.H., Hall, C.S., Scott, M.J., et al. (1998) In Vitro Characterization of a Novel, Tissue-Targeted Ultrasonic Contrast System with Acoustic Microscopy. The Journal of the Acoustical Society of America, 104, 3665-3672. http://dx.doi.org/10.1121/1.423948
Morawski, A.M., Winter, P.M., Crowder, K.C., Caruthers, S.D., Fuhrhop, R.W., Scott, M.J., et al. (2004) Targeted Nanoparticles for Quantitative Imaging of Sparse Molecular Epitopes with MRI. Magnetic Resonance in Medicine, 51, 480-486. http://dx.doi.org/10.1002/mrm.20010
Winter, P.M., Morawski, A.M., Caruthers, S.D., Fuhrhop, R.W., Zhang, H., Williams, T.A., et al. (2003) Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis with Alpha(v) Beta3-Integrin-Targeted Nanoparticles. Circulation, 108, 2270-2274. http://dx.doi.org/10.1161/01.CIR.0000093185.16083.95
Kao, C.Y., Hoffman, E.A., Beck, K.C., Bellamkonda, R.V. and Annapragada, A.V. (2003) Long-Residence-Time Nano-Scale Liposomal Iohexol for X-Ray-Based Blood Pool Imaging. Academic Radiology, 10, 475-483. http://dx.doi.org/10.1016/S1076-6332(03)80055-7
Mukundan Jr., S., Ghaghada, K.B., Badea, C.T., Kao, C.Y., Hedlund, L.W., Provenzale, J.M., et al. (2006) A Liposomal Nanoscale Contrast Agent for Preclinical CT in Mice. American Journal of Roentgenology, 186, 300-307. http://dx.doi.org/10.2214/AJR.05.0523
Christodoulides, N., Dharshan, P., Wong, J., Floriano, P.F., Neikirk, D. and McDevitt, J.T. (2007) A Microchip-Based Assay for Interleukin-6. Methods in Molecular Biology, 385, 131-144. http://dx.doi.org/10.1007/978-1-59745-426-1_10
Goodey, A., Lavigne, J.J., Savoy, S.M., Rodriquez, M.D., Curey, T., Tsao, A., et al. (2001) Development of Multianalyte Sensor Arrays Composed of Chemically Derivitized Polymeric Microspheres Localized in Micromachined Cavities. Journal of the American Chemical Society, 123, 2559-2570. http://dx.doi.org/10.1021/ja003341l
Christodoulides, N., Tran, M., Floriano, P.N., Rodriquez, M., Goodey, A., Ali, M., et al. (2002) A Microchip-Based Multianalyte Assay System for the Assessment of Cardiac Risk. Analytical Chemistry, 74, 3030-3036. http://dx.doi.org/10.1021/ac011150a
Ali, M.F., Kirby, R., Goodey, A.P., Rodriguez, M.D., Ellington, A.D., Neikirk, D.P., et al. (2003) DNA Hybridization and Discrimination of Singlenucleotide Mismatches Using Chip-Based Microbead Arrays. Analytical Chemistry, 75, 4732-4739. http://dx.doi.org/10.1021/ac034106z
Jokerst, J.V., Raamanathan, A., Christodoulides, N., Floriano, P.N., Pollard, A.A., Simmons, G.W., et al. (2009) Nano-Bio-Chips for High Performance Multiplexed Protein Detection: Determinations of Cancer Biomarkers in Serum and Saliva Using Quantum Dot Bioconjugate Labels. Biosensors and Bioelectronics, 24, 3622-3629. http://dx.doi.org/10.1016/j.bios.2009.05.026
Lavigne, J.J., Savoy, S., Clevenger, M.B., Ritchie, J.E., McDoniel, B., Yoo, S.J., et al. (1998) Solution-Based Analysis of Multiple Analytes by a Sensor Array: Toward the Development of an “Electronic Tongue”. Journal of the American Chemical Society, 120, 6429-6430. http://dx.doi.org/10.1021/ja9743405
Christodoulides, N., Floriano, P.N., Mohanty, S., Dharshan, P., Griffin, M., Lennart, A., et al. (2007) Lab-on-a-Chip Methods for Point of Care Measurements of Salivary Bio-markers of Periodontitis. Annals of the New York Academy of Sciences, 1098, 411-428. http://dx.doi.org/10.1196/annals.1384.035
Christodoulides, N., Mohanty, S., Miller, C.S., Langub, M.C., Floriano, P.N., Dharshan, P., et al. (2005) Application of Microchip Assay System for the Measurement of C-Reactive Protein in Human Saliva. Lab on a Chip, 5, 261-269. http://dx.doi.org/10.1039/b414194f
Christodoulides, N., Floriano, P.N., Sanchez, X., Li, L.Y., Hocquard, K., Patton, A., et al. (2012) Programmable Bio-Nanochip Technology for the Diagnosis of Cardiovascular Disease at the Point of Care. Methodist Debakey Cardiovascular Journal, 8, 6-12. http://dx.doi.org/10.14797/mdcj-8-1-6
Floriano, P.N., Christodoulides, N., Miller, C.S., Ebersole, J.L., Spertus, J., Rose, B.G., et al. (2009) Use of Saliva-Based Nano-Biochip Tests for Acute Myocardial Infarction at the Point of Care: A Feasibility Study. Clinical Chemistry, 55, 1530-1538. http://dx.doi.org/10.1373/clinchem.2008.117713
Vasan, R.S. (2006) Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations. Circulation, 113, 2335-2362. http://dx.doi.org/10.1161/CIRCULATIONAHA.104.482570
Danesh, J., Lewington, S., Thompson, S.G., Lowe, G.D., Collins, R., Kostis, J.B., et al. (2005) Plasma Fibrinogen Level and the Risk of Major Cardiovascular Diseases and Nonvascular Mortality: An Individual Participant Meta-Analysis. JAMA, 294, 1799-1809.
Cushman, M., Lemaitre, R.N., Kuller, L.H., Psaty, B.M., Macy, E.M., Sharrett, A.R., et al. (1999) Fibrinolytic Activation Markers Predict Myocardial Infarction in the Elderly. The Cardiovascular Health Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 19, 493-498. http://dx.doi.org/10.1161/01.ATV.19.3.493
Wang, T.J., Larson, M.G., Levy, D., Benjamin, E.J., Leip, E.P., Omland, T., et al. (2004) Plasma Natriuretic Peptide Levels and the Risk of Cardiovascular Events and Death. New England Journal of Medicine, 350, 655-663. http://dx.doi.org/10.1056/NEJMoa031994
Danesh, J., Wheeler, J.G., Hirschfield, G.M., Eda, S., Eiriksdottir, G., Rumley, A., et al. (2004) C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease. New England Journal of Medicine, 350, 1387-1397. http://dx.doi.org/10.1056/NEJMoa032804
Mangoni, A.A. and Jackson, S.H. (2002) Homocysteine and Cardiovascular Disease: Current Evidence and Future Prospects. The American Journal of Medicine, 112, 556-565. http://dx.doi.org/10.1016/S0002-9343(02)01021-5
Gaspari, M., Cheng, M., Terracciano, R., Liu, X., Nijdam, A.J., Vaccari, L., et al. (2006) Nanoporous Surfaces as Harvesting Agents for Mass Spectrometric Analysis of Peptides in Human Plasma. Journal of Proteome Research, 5, 1261-1266. http://dx.doi.org/10.1021/pr050417+
Luchini, A., Geho, D.H., Bishop, B., Tran, D., Xia, C., Dufour, R.L., et al. (2008) Smart Hydrogel Particles: Biomarker Harvesting: One-Step Affinity Purification, Size Exclusion, and Protection against Degradation. Nano Letters, 8, 350-361. http://dx.doi.org/10.1021/nl072174l
Cui, Y., Wei, Q., Park, H. and Lieber, C.M. (2001) Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species. Science, 293, 1289-1292. http://dx.doi.org/10.1126/science.1062711
Yang, Z. and Zhou, D.M. (2006) Cardiac Markers and Their Point-of-Care Testing for Diagnosis of Acute Myocardial Infarction. Clinical Biochemistry, 39, 771-780. http://dx.doi.org/10.1016/j.clinbiochem.2006.05.011
Brogan Jr., G.X. and Bock, J.L. (1998) Cardiac Marker Point-of-Care Testing in the Emergency Department and Cardiac Care Unit. Clinical Chemistry, 44, 1865-1869.
Park, J.S., Cho, M.K., Lee, E.J., Ahn, K.Y., Lee, K.E., Jung, J.H., et al. (2009) A Highly Sensitive and Selective Diagnostic Assay Based on Virus Nanoparticles. Nature Nanotechnology, 4, 259-264. http://dx.doi.org/10.1038/nnano.2009.38
Vogt, S., Troitzsch, D., Späth, S. and Moosdorf, R. (2004) Efficacy of Ion-Selective Probes in Early Epicardial in Vivo Detection of Myocardial Ischemia. Physiological Measurement, 25, N21-N26. http://dx.doi.org/10.1088/0967-3334/25/6/N02
Ji, T., Rai, P., Jung, S. and Varadan, V.K. (2008) In Vitro Evaluation of Flexible pH and Potassium Ion-Sensitive Organic Field Effect Transistor Sensors. Applied Physics Letters, 92, Article ID: 233304. http://dx.doi.org/10.1063/1.2936296
Barhoumi, H., Haddad, R., Maaref, A., Bausells, J., Bessueille, F., Léonard, D., et al. (2001) New Technology for Multi-Sensor Silicon Needles for Biomedical Applications. Sensors and Actuators B: Chemical, 78, 279-284. http://dx.doi.org/10.1016/S0925-4005(01)00826-7
Shin, K.H., Moon, C.R., Lee, T.H., Lim, C.H. and Kim, Y.J. (2005) Flexible Wireless Pressure Sensor Module. Sensors and Actuators A, 123-124, 30-35. http://dx.doi.org/10.1016/j.sna.2005.01.008
Kim, J.-H., Heller, D.A., Jin, H., Barone, P.W., Song, C., Zhang, J.Q., et al. (2009) The Rational Design of Nitric Oxide Selectivity in Single-Walled Carbon Nanotube Nearinfrared Fluorescence Sensors for Biological Detection. Nature Chemistry, 1, 473-481. http://dx.doi.org/10.1038/nchem.332
Lammers, T., Kiessling, F., Hennink, W.E. and Storm, G. (2010) Nanotheranostics and Image-Guided Drug Delivery: Current Concepts and Future Directions. Molecular Pharmaceutics, 7, 1899-1912. http://dx.doi.org/10.1021/mp100228v
Barenholz, Y. (2012) Doxil®—The First FDA-Approved Nano-Drug: Lessons Learned. Journal of Controlled Release, 160, 117-134. http://dx.doi.org/10.1016/j.jconrel.2012.03.020
Mufamadi, M.S., Pillay, V., Choonara, Y.E., Du Toit, L.C., Modi, G. and Naidoo, D. (2011) A Review on Composite Liposomal Technologies for Specialized Drug Delivery. Journal of Drug Delivery, 2011, Article ID: 939851. http://dx.doi.org/10.1155/2011/939851
Maurer, N., Fenske, D.B. and Cullis, P.R. (2001) Developments in Liposomal Drug Delivery Systems. Expert Opinion on Biological Therapy, 1, 923-947. http://dx.doi.org/10.1517/14712598.1.6.923
Immordino, M.L., Dosio, F. and Cattel, L. (2006) Stealth Liposomes: Review of the Basic Science, Rationale, and Clinical Applications, Existing and Potential. International Journal of Nanomedicine, 1, 297-315.
Hedman, M., Hartikainen, J. and Syvanne, M. (2003) Safety and Feasibility of Catheter-Based Local Intracoronary Vascular Endothelial Growth Factor Gene Transfer in the Prevention of Postangioplasty and In-Stent Restenosis and in the Treatment of Chronic Myocardial Ischemia: Phase II Results of the Kuopio Angiogenesis Trial (KAT). Circulation, 107, 2677-2683. http://dx.doi.org/10.1161/01.CIR.0000070540.80780.92
Margolis, J., McDonald, J., Heuser, R., Klinke, P., Waksman, R., Virmani, R., et al. (2007) Systemic Nanoparticle Paclitaxel (Nab-Paclitaxel) for In-Stent Restenosis I (SNAPIST-I): A First-in-Human Safety and Dose-Finding Study. Clinical Cardiology, 30, 165-170. http://dx.doi.org/10.1002/clc.20066
McDowell, G., Slevin, M. and Krupinski, J. (2011) Nanotechnology for the Treatment of Coronary in Stent Restenosis: A Clinical Perspective. Vascular Cell, 3, 8. http://dx.doi.org/10.1186/2045-824X-3-8
Zhang, H., Li, N. and Sirish, P. (2012) The Cargo of CRPPR-Conjugated Liposomes Crosses the Intact Murine Cardiac Endothelium. Journal of Controlled Release, 163, 10-17. http://dx.doi.org/10.1016/j.jconrel.2012.06.038
Harel-Adar, T., Ben Mordechai, T., Amsalem, Y., Feinberg, M.S., Leor, J. and Cohen, S. (2011) Modulation of Cardiac Macrophages by Phosphatidylserine-Presenting Liposomes Improves Infarct Repair. Proceedings of the National Academy of Sciences of the United States of America, 108, 1827-1832. http://dx.doi.org/10.1073/pnas.1015623108
Dvir, T., Bauer, M., Schroeder, A., Tsui, J.H., Anderson, D.G., Langer, R., et al. (2011) Nanoparticles Targeting the Infarcted Heart. Nano Letters, 11, 4411-4444. http://dx.doi.org/10.1021/nl2025882
Lestini, B.J., Sagnella, S.M., Xu, Z., Shive, M.S., Richter, N.J., Jayaseharan, J., et al. (2002) Surface Modification of Liposomes for Selective Cell Targeting in Cardiovascular Drug Delivery. Journal of Controlled Release, 78, 235-247. http://dx.doi.org/10.1016/S0168-3659(01)00505-3
Holland, N.B., Qiu, Y., Ruegsegger, M. and Marchant, R.E. (1998) Biomimetic Engineering of Non-Adhesive Glycocalyx-Like Surfaces Using Oligosaccharide Surfactant Polymers. Nature, 392, 799-801. http://dx.doi.org/10.1038/33894
Zhu, J., Xue, J., Guo, Z., Zhang, L. and Marchant, R.E. (2007) Biomimetic Glycoliposomes as Nanocarriers for Targeting P-Selectin on Activated Platelets. Bioconjugate Chemistry, 18, 1366-1369. http://dx.doi.org/10.1021/bc700212b
Joner, M., Morimoto, K., Kasukawa, H., Steigarwald, K., Meri, S., Nakazawa, G., et al. (2008) Site-Specific Targeting of Nanoparticle Prednisolone Reduces In-Stent Restenosis in a Rabbit Model of Established Atheroma. Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 1960-1966. http://dx.doi.org/10.1161/ATVBAHA.108.170662
Cho, B.H., Park, J.R., Nakamura, M.T., Odintsov, B.M., Wallig, M.A. and Chung, B.H. (2010) Synthetic Dimyristoylphosphatidylcholine Liposomes Assimilating into High-Density Lipoprotein Promote Regression of Atherosclerotic Lesions in Cholesterol-Fed Rabbits. Experimental Biology and Medicine, 235, 1194-1203. http://dx.doi.org/10.1258/ebm.2010.009320
Walton, B.L., Leja, M., Vickers, K.C., Estevez-Fernandez, M., Sanguino, A., Wang, E., et al. (2010) Delivery of Negatively Charged Liposomes into the Atheromas of Watanabe Heritable Hyperlipidemic Rabbits. Vascular Medicine, 15, 307-313. http://dx.doi.org/10.1177/1358863X10374118
Danenberg, H.D., Fishbein, I., Gao, J., Mönkkönen, J., Reich, R., Gati, I., et al. (2002) Macrophage Depletion by Clodronate-Containing Liposomes Reduces Neointimal Formation after Balloon Injury in Rats and Rabbits. Circulation, 106, 599-605. http://dx.doi.org/10.1161/01.CIR.0000023532.98469.48
Buxton, D.B. (2009) Nanomedicine for the Management of Lung and Blood Diseases. Nanomedicine, 4, 331-339. http://dx.doi.org/10.2217/nnm.09.8
Cyrus, T., Zhang, H., Allen, J.S., Williams, T.A., Hu, G., Caruthers, S.D., et al. (2008) Intramural Delivery of Rapamycin with Alphavbeta3-Targeted Paramagnetic Nanoparticles Inhibits Stenosis after Balloon Injury. Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 820-826. http://dx.doi.org/10.1161/ATVBAHA.107.156281
Winter, P.M., Caruthers, S.D., Zhang, H., Williams, T.A., Wickline, S.A. and Lanza, G.M. (2008) Antiangiogenic Synergism of Integrin-Targeted Fumagillin Nanoparticles and Atorvastatin in Atherosclerosis. JACC: Cardiovascular Imaging, 1, 624-634. http://dx.doi.org/10.1016/j.jcmg.2008.06.003
Hoffmann, R., Mintz, G.S., Dussaillant, G.R., Popma, J.J., Pichard, A.D., Satler, L.F., et al. (1996) Patterns and Mechanisms of In-Stent Restenosis. A Serial Intravascular Ultrasound Study. Circulation, 94, 1247-1254. http://dx.doi.org/10.1161/01.CIR.94.6.1247
Samaroo, H.D., Lu, J. and Webster, T.J. (2008) Enhanced Endothelial Cell Density on NiTi Surfaces with Sub-Micron to Nanometer Roughness. International Journal of Nanomedicine, 3, 75-82.
Kastrati, A., Mehilli, J., Pache, J., Kaiser, C., Valgimigli, M., Kelbaek, H., et al. (2007) Analysis of 14 Trials Comparing Sirolimus-Eluting Stents with Bare-Metal Stents. New England Journal of Medicine, 356, 1030-1039. http://dx.doi.org/10.1056/NEJMoa067484
Lagerqvist, B., James, S.K., Stenestrand, U., Lindbäck, J., Nilsson, T., Wallentin, L., et al. (2007) Long-Term Outcomes with Drug-Eluting Stents versus Bare-Metal Stents in Sweden. New England Journal of Medicine, 356, 1009-1019. http://dx.doi.org/10.1056/NEJMoa067722
Mauri, L., Hsieh, W.H., Massaro, J.M., Ho, K.K., D’Agostino, R. and Cutlip, D.E. (2007) Stent Thrombosis in Randomized Clinical Trials of Drug-Eluting Stents. New England Journal of Medicine, 356, 1020-1029. http://dx.doi.org/10.1056/NEJMoa067731
Stone, G.W., Moses, J.W., Ellis, S.G., Schofer, J., Dawkins, K.D., Morice, M.C., et al. (2007) Safety and Efficacy of Sirolimus- and Paclitaxel-Eluting Coronary Stents. New England Journal of Medicine, 356, 998-1008. http://dx.doi.org/10.1056/NEJMoa067193
Wieneke, H., Dirsch, O., Sawitowski, T., Gu, Y.L., Brauer, H., Dahmen, U., et al. (2003) Synergistic Effects of a Novel Nanoporous Stent Coating and Tacrolimus on Intima Proliferation in Rabbits. Catheterization and Cardiovascular Interventions, 60, 399-407. http://dx.doi.org/10.1002/ccd.10664
Bhargava, B., Reddy, N.K., Karthikeyan, G., Raju, R., Mishra, S., Singh, S., et al. (2006) A Novel Paclitaxel-Eluting Porous Carbon-Carbon Nanoparticle Coated, Nonpolymeric Cobalt-Chromium Stent: Evaluation in a Porcine Model. Catheterization and Cardiovascular Interventions, 67, 698-702. http://dx.doi.org/10.1002/ccd.20698
Ayon, A.A., Cantu, M., Chava, K., Agrawal, C.M., Feldman, M.D., Johnson, D., et al. (2006) Drug Loading of Nanoporous TiO2 Films. Biomedical Materials, 1, L11-L15. http://dx.doi.org/10.1088/1748-6041/1/4/L01
Liu, D.M., Yang, Q. and Troczynski, T. (2002) Sol-Gel Hydroxyapatite Coatings on Stainless Steel Substrates. Biomaterials, 23, 691-698. http://dx.doi.org/10.1016/S0142-9612(01)00157-0
Caves, J.M. and Chaikof, E.L. (2006) The Evolving Impact of Microfabrication and Nanotechnology on Stent Design. Journal of Vascular Surgery, 44, 1363-1368. http://dx.doi.org/10.1016/j.jvs.2006.08.046