The process of sperm production is well understood, but the studies of essential nutritional elements which are necessary for successful spermatogenesis are not deeply studied as yet. Our review focuses on integrating available information of various nutritional elements involved in spermatogenesis, sperm maturation and male reproductive system development, such as Zinc, Selenium, Folate, Vitamins and others. Antioxidants protect sperm from further oxidative damage during the entire sperm production. Other nutrients assist to improve sperm quality through different ways. The important roles of macronutrients like lipids, amino acids and proteins are emphasized here. These macronutrients constitute major components of the spermatozoa. Effects of nutritional elements on the development of Sertoli cells and Leydig cells, sperm motility and semen quality, capacity of capacitation and fertilization are discussed. A review of these areas will provide researchers with a better understanding of the compulsory participation of these nutrients in male reproductive processes. This review also pointed out gaps in current studies which will require further investigations.
M. A. Emanuele, M. D. and N. V. Emanuele, M. D., “Alcohol's effects on male reproduction,” Alcohol Health & Research World, vol. 22, no.3, 1998, pp.195-201.
G. L. Foley, “Overview of male reproductive pathology,” Toxicologic Pathology, vol. 29, no.1, 2001, pp. 49-63.
M. Hidiroglou, and J. E. Knipfel, “Zinc in mammalian sperm: A review,” Journal of Dairy Science, vol. 67, 1984, pp. 1147-1156.
S. S. W. Chung, X. Wang, D. J. Wolgemuth, “Expression of retinoic acid receptor alpha in the germline is essential for proper cellular association and spermiogenesis during spermatogenesis,” Development, vol.136, no.12, 2009, pp. 2091-2100.
S. B. Abdu, “Effect of vitamins deficiencies on the histological structure of the testis of albino mice Mus musculus,” Saudi Journal of Biological Sciences, vol.15, no.2, December 2008, pp. 269-278.
N. J Chinoy and Arti Sharma, Ahmedabad, “Amelioration of fluoride toxicity by vitamins E and D in reproductive functions of male mice,” Fluoride, vol.31, no.4, 1998, pp. 203-216.
I. M. W. Ebisch, C. M. G. Thomas, W. H. M. Peters, D. D. M.Braat and R. P. M. Steegers-Theunissen, “The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility,” Human Reproduction Update, vol. 13, no.2, 2007, pp.163-174.
W. C. Hawkes, and P. J. Turek, “Effects of dietary selenium on sperm motility in healthy men,” Journal of Andrology, vol. 22, no.5, October 2001, pp. 764-772.
K. Yokoi, E. O. Uthus, and F. H. Nielsen, “Nickel deficiency diminishes sperm quantity and movement in rats,” Biological Trace Element Research, vol. 93, 2003, pp. 141-153.
B. Lee, M. Pine, L. Johnson, V. Rettori, J. K. Hiney and W. L. Dees, “Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats,” Reproductive Toxicology, vol.22, no.4, 2006, pp. 580-585.
T. E. Tuormaa, “Chromium, selenium and copper and other trace minerals in health and reproduction,” Journal of Orthomolecular Medicine, vol.15, no.3, 2000, pp. 145-157.
Y. Aksoy, H. Aksoy, K. Altinkaynak, H. R. Aydin, A. Ozkan, “Sperm fatty acid composition in subfertile men,” Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 75, August 2006, pp.75-79.
E. Zambrano, G. L. Rodríguez-González, C. Guzman, R. García-Becerra, L. Boeck, L. Díaz, M. Menjivar, F. Larrea, and P. W. Nathanielsz, “A maternal low protein diet during pregnancy and lactation in the rat impairs male reproductive development,” Journal of Physiology, vol. 563, February 2005, pp. 275-284.
G. Wu, F. W. Bazer, T.A. Davis, S.W. Kim, P. Li, J. Marc Rhoads, M. C. Satterfield, S. B. Smith, T. E. Spencer, and Y. Yin, “Arginine metabolism and nutrition in growth, health and disease,” Amino Acids, vol. 37, no. 1, May 2009, pp. 153-168.
C. M. Ng, M. R. Blackman, C. Wang, and R. S. Swerdloff, “The role of carnitine in the male reproductive system” Annals New York Academy of Sciences, vol. 1033, November 2004, pp. 177-188.
R. C. Jones, “To store or mature spermatozoa? The primary role of the Epididymis,” International Journal of Andrology, vol.22, no.2, February 1999, pp. 57-67.
W. Y. Wong, G. Flik, P. M. Groenena, D. W. Swinkels, C. M. Thomas, J. H. J. Copius-Peereboom, H. M. W. M. Merkus and R. P. M. Steegers-Theunissen, “The impact of calcium, magnesium, zinc, and copper in blood and seminal plasma on semen parameters in men,” Reproductive Toxicology, vol.15, no.2, March 2001, pp.131-136.
C. E. A. Oliveira, C. A. Badú, W. M. Ferreira, E. B. Kamwa, and Lana, A.M.Q., “Effects of dietary zinc supplementation on spermatic characteristics of rabbit breeders,” 8th World Rabbit Congress, Mexico, September 2004, pp. 315-321.
K. E. Mason, W. A. Burns and J. C. Smith Jr., “Testicular damage associated with zinc deficiency in pre- and postpubertal rats: Response to zinc repletion,” The Journal of Nutrition, vol.112, 1982, pp. 1019-1028.
D. Y. Liu, B. S. Sie, M. L. Liu, F. Agresta and H. W. G. Baker, “Relationship between seminal plasma zinc concentration and spermatozoa-zona pellucida binding and the ZP-induced acrosome reaction in subfertile men,” Asian Journal of Andrology, vol. 11 no. 4, May 2009, pp. 499-507.
N. Batra, B. Nehru and M. P. Bansal, “Reproductive potential of male Portan rats exposed to various levels of lead with regard to zinc status,” British Journal of Nutrition, vol. 91, no.3, 2004, pp. 387-391.
P. Kaur and M. P. Bansal, “Effect of selenium-induced oxidative stress on the cell kinetics in testis and reproductive ability of male mice,” Nutrition vol. 21, no.3, 2005, pp. 351-357.
G. J. Beckett and J. R. Arthur,”Selenium and endocrine systems,” Journal of Endocrinology, vol.84, no.3, 2005, pp. 455-465.
B. M. Hadaszadeh and A. H. Beggs, “Selenoproteins and their impact on human health through diverse physiological pathways,” Physiology, vol. 21, 2006, pp. 307 - 315.
S. C. Schriever, K. M. HBarnesH, J. K. HEvensonH, A. M. HRaines Hand R. A. HSunde, H“Selenium requirements are higher for glutathione peroxidase-1 mRNA than gpx1 activity in rat testis,” Exp Biol Med (Maywood), vol.234, no.9, May 2009, pp. 513 – 521.
I.M. Ebisch, W.H. Peters, C.M. Thomas, A.M. Wetzels, P.G. HPeer Hand R.P. Steegers-Theunissen, “Homocysteine, glutathione and related thiols affect fertility parameters in the (sub)fertile couple,” Human Reproduction, vol. 21, no. 7, July 2006, pp. 1725-1733.
S. S. Young, B. Eskenazi, F. M. Marchetti, G. Block and A. J. Wyrobek, “The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men,” Human Reproduction vol.23, no.5, May 2008 pp. 1014-1022.
S. Wang, G. Wang, B. E. Barton, T. F. Murphy and H. F. Huang, “Beneficial effects of vitamin E in sperm functions in the rat after spinal cord injury,” Journal of Andrology, vol. 28, no. 2, March 2007, pp. 334-341.
D. Yue, L. Yan , H. Luo , X. Xu and X. Jin, “Effect of Vitamin E supplementation on semen quality and the testicular cell membranal and mitochondrial antioxidant abilities in Aohan fine-wool sheep,” Animal Reproduction Science, vol. 118, no. 2-4, April 2010, pp. 217-222.
H. Begum, A. B. M. Moniruddin and K. Nahar, “Environmental and Nutritional Aspect in Male Infertility,” Journal of Medicine, vol. 10, no. 1, 2009, pp. 16-19.
M. L.Kann, and C. Serres, “Development and Initiation of Sperm Motility in the Hamster Epididymis,” Reproduction Nutrition Development, vol.20, no.6, 1980, pp. 1739-1749.
M. Schneider, H. F?rster, A. Boersma, A. Seiler, H. Wehnes, F. Sinowatz, C. Neumüller, M. J. Deutsch, A. Walch, M. Hrabé de Angelis, W. Wurst, F. Ursini, A. Roveri, M. Maleszewski, M. Maiorino, and M. Conrad, “Mitochondrial glutathione peroxidase 4 disruption causes male infertility,” Faseb Journal, vol. 23, no. 9, September 2009, pp. 3233-3242.
G.E. Olson, V.P. Winfrey, K.E. Hill and R.F. Burk, “Sequential development of flagellar defects in spermatids and epididymal spermatozoa of selenium-deficient rats,” Reproduction, vol.127, no.3, 2004, pp. 335-342.
K. M. A. Tareq, A.G. Miah, U. Salma, M. Yoshida and H. Tsujii, “Effect of selenium and vitamin E on acrosome reaction in porcine spermatozoa,” Reproduction of Medicine Biology, vol. 9, no. 2, 2010, pp. 73–81.
S. A. Suleiman, M. E. Ali, Z. M. Zaki, E. M. el-Malik and M. A. Nasr, “Lipid peroxidation and human sperm motility: protective role of vitamin E,” Journal of Andrology, vol.17, no.5, September – October 1996, pp. 530-537.
P. E. Visconti, X. Ning, M.W. HFornésH, J.G. HAlvarezH, P. HSteinH, S.A. HConnors Hand G.S. HKopfH, “Cholesterol efflux-mediated signal transduction in mammalian sperm: Cholesterol release signals an increase in protein tyrosine phosphorylation during mouse sperm capacitation.” Developmental Biology, vol. 214, no. 2, October 1999, pp. 429-443.
S. Kothari, A. Thompson, A. Agarwal and S. S. du Plessis, “Free radicals: Their beneficial and detrimental effects on sperm function,” Indian Journal of Experimental Biology, vol.48, no.5, May 2010, pp. 425-435.
A. M. Uhland, G.G. Kwiecinski and H.F. DeLuca, “Normalization of serum calcium restores fertility in vitamin D-deficient male rats,” Journal of Nutrition, vol.122, no.6, June 1992, pp. 1338-44.
M. S?nmez, G. Türk and A. Yüce, “The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats,” Theriogenology, vol.63, no.7, April 2005, pp. 2063-2072.
Internet Available: http://en.wikipedia.org/wiki/Semen
I. Audet, N. Bérubé, J. L. Bailey, J. P. Laforest and J. J. Matte, “Effects of dietary vitamin supplementation and semen collection frequency on reproductive performance and semen quality in boars,” Journal of Animal Science, vol. 87, no. 6, January 2009, pp. 1960-1970.
L. F. Brito, A. D. Barth, N. C. Rawlings, R. E. Wilde, D. H. Crews Jr, P. S. Mir and J. P. Kastelic, “Effect of improved nutrition during calfhood on serum metabolic hormones, gonadotropins, and testosterone concentrations, and on testicular development in bulls,” Domestic Animal Endocrinology, vol. 33, no. 4, November 2007, pp. 460-469.
D. V. Davies, T. Mann and L. E. Rowson, “Effect of Nutrition on the Onset of Male Sex Hormone Activity and Sperm Formation in Monozygous Bull-Calves,” Proceedings of the Royal Society of London Series B - Biological Sciences, vol. 147, no. 928, December 1957, pp. 332-351.
A. M. Almeida, L. M. J. Schwalbach, L. A. Cardoso and J. P. C. Greyling “Scrotal, testicular and semen characteristics of young Boer bucks fed winter veld hay: The effect of nutritional supplementation,” Small Ruminant Research, vol.73, no.1-3, November 2007, pp. 216-220.
J. A. Conquer, J. B. Martin , I. Tummon, L. Watson and F. Tekpetey, “Effect of DHA supplementation on DHA status and sperm motility in asthenozoospermic males,” Lipids, vol.35, no.2, February 2000, pp. 149-154.
A. A. Zalata, A. B. Christophe, C. E. HDepuydtH, F. HSchoonjans Hand F.H. HComhaireH, “The fatty acid composition of phospholipids of spermatozoa from infertile patients,” Molecular Human Reproduction, vol. 4, no. 2, 1998, pp. 111-118.
J. A. Rooke, C. C. Shao and B. K. Speake, “Effects of feeding tuna oil on the lipid composition of pig spermatozoa and in vitro characteristics of semen,” Reproduction, vol. 121, no. 2, 2001, pp. 315-322.
D. S. Lin, M. Neuringer and W. E. Connor, “Selective changes of docosahexaenoic acid-containing phospholipid molecular species in monkey testis during puberty,” Journal of Lipid Research, vol. 45, no.3, March 2004, pp. 529-535.
S. P. Brinsko, D. D. Varner, C. C. Love, T. L. Blanchard, B. C. Day and M. E. Wilson, “Effect of feeding a DHA-enriched nutriceutical on the quality of fresh, cooled and frozen stallion semen,” Theriogenology, vol. 63, no. 5, March 2005, pp. 1519-1527.
C. Jeulin and L. M. Lewin, “Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa,” Human Reproduction Update, vol.2, no.2, March - April 1996, pp. 87-102.
X. Zhou, F. Liu and S. Zhai, “Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review,” Asia Pacific of Journal Clinical Nutrition, vol. 16, Suppl 1, 2007, pp. 383-390.
G. Bleau, J. Lemarbre, Faucher G, K. D. Roberts, A. Chapdelaine, “Semen selenium and human fertility,” Fertility & Sterility. , vol. 42, no.6 , 1984, pp. 890-894.
E. R. Miller 3rd, R. Pastor-Barriuso, D. Dalal, R. A. Riemersma, L. J. Appel, E. Guallar, “Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality,” Annals of Internal Medicine, vol. 142, no. 1, 2005, pp. 37-46. .
T. M. Gliozzi, L. Zaniboni, A. Maldjian, F. Luzi, L. Maertens, S.Cerolini, “Quality and lipid composition of spermatozoa in rabbits fed DHA and vitamin E rich diets,” Theriogenology, vol. 71, no. 6, 2009, pp. 910-919.
P. Bolle, M. G. Evandri, L. Saso, “The controversial efficacy of vitamin E for human male infertility,” Contraception, vol. 6, no. 4, 2002, pp.313-315.
Functions of essential nutrition for high quality spermatogenesis — Oak Academic Publishing