Staphylococcus aureus is pathogenic to humans with worldwide health care concern due to its ability to evade the immune system and develop resistance to multiple drugs. Reg family proteins are C-type lectins with antimicrobial properties. Bacterial aggregation through binding to microbial cell surface sugar and/or lipid moieties is key mechanism employed in the process. In the present study we have analysed the antimicrobial effect of human REG I α on S. aureus . Aggregation of mid-log phase culture of S. aureus was observed in presence of purified recombinant REG I α . Therefore REG I α can be applied in eliminating S. aureus infections in humans.
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