The present study was undertaken to investigate the effect of the ethanolic extract of <i> Syzygium aromaticum </i> to albino rats. Forty eight Albino rats were employed to test the safety and the anti-inflammatory effect of the extract. Safety of the extract was examined on experimental animal’s model at three dose levels of the extract orally in daily doses for three weeks. Effects of <i> S. aromati cum </i> on rats revealed no significant effect on biochemical or haematological parameters. The anti-inflammatory effect of the extract was tested in four equal groups; groups 1 and 2 were treated with 250 and 500 mg/kg of the extract, respectively, group 3 was treated with indomethacine and group 4 was the untreated control. Carrageenan was used as an acute form inducer of inflamma tion. Indomethacin e , the non-steroidal anti-inflammatory drugs (NSAIDs), was used as a reference compound. Oedema size was monitored at the 1 st , 2 nd , 4 th , 6 th and after 24 hours. The ethanolic extract of <i> S. aromaticum </i> showed signifi cant (P < 0.001) decreased in the o e dema size at efficacy rates of 79.41 % , 82.39 % and 63.92% for the dose, 500 mg/kg body weight at the 2 nd , 4 th and 6 th hour respectively higher than that produced by indomethacine.
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