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Association of COL1A1 rs180012 SNP and Fibromyalgia Suggests the Implication of Collagen Structure in Musculoskeletal Pain
Departamento de Genética Molecular, Citogen, Zaragoza, Spain
Departmento de Fisiatría y Enfermería, Facultad de Ciencias de la Salud y el Deporte, Universidad de Zaragoza. Zaragoza, Spain
Departamento de Bioquímica, Biología Molecular y Celular—Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER)—Instituto de Investigación Sanitaria de Aragón (IISA), Zaragoza, Spain
Departamento de Bioquímica, Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain
- 1 Departamento de Genética Molecular, Citogen, Zaragoza, Spain
- 2 Departmento de Fisiatría y Enfermería, Facultad de Ciencias de la Salud y el Deporte, Universidad de Zaragoza. Zaragoza, Spain
- 3 Departamento de Bioquímica, Biología Molecular y Celular—Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER)—Instituto de Investigación Sanitaria de Aragón (IISA), Zaragoza, Spain
- 4 Departamento de Bioquímica, Biología Molecular y Celular, Universidad de Zaragoza, Zaragoza, Spain
Advances in Bioscience and Biotechnology·Volume 09 (2018)·Pages 83–89·Published 14 February 2018·DOI10.4236/abb.2018.92007
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Abstract
Fibromyalgia (FM) is a complex, chronic condition, which causes widespread musculoskeletal pain, fatigue and a variety of other symptoms. Many polymorphisms related to neuroendocrine system function as the ApoE isoforms, Val158Met polymorphism in COMT, as well as a 44 bp deletion located in 5-HTTLPR, have been studied. Other polymorphisms have been related to inflammatory response such as the 70 bp VNTR in IL-4 or to citokine levels. Furthermore, some studies focused on finding out new FM related SNPs, have been performed by genome wide association scan (GWAS). The target of this work was to study a possible linkage of a collagen type I polymorphism (COL1A1 rs180012 SNP) affecting bone mineralization, with fibromyalgia. Results obtained show a clear association of ss homozygous genotype with FM patients no dependent on bone mineralization.
KeywordsFibromyalgiaGenotypeCollagenBone Mineral DensitySP1
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