The conditional mutations in D. melanogaster are produced by gamma-irradiation, maintained in laboratory cultures, and inherited as gene mutations. However, their manifestation differs from the conventional mutations by several specific features. The most noticeable specific feature is their conditional nature, i.e. , a conditional mutation manifests itself in the individual s of a certain genotype being silent in the individual s with another genotype. A particular procedure for mutation recovery determines what these genotypes will be. An overwhelming number of mutations are conditional dominant lethals. The viable mutation carriers display a drastically decreased fertility. Early zygotic lethality is inherited according to parental type (maternal or paternal). The carriers of conditional mutations give the offspring with a high rate of monstrosities. The possibility for the offspring to form monstrosities is inherited according to a parental (maternal or paternal) type. The level of fertility of conditional mutants is altered by chromosomal rearrangements. The chromosomal rearrangements themselves cause a decrease in fertility. Lethality of the progenies produced by the parents carrying rearrangements is inherited according to a parental (maternal or paternal) type. The results allow for a set of logical arguments in favor of that 1) the genome has a specialized system of genes (ontogenes) that control the course of individual development; 2) unlike a classical gene, acting according to the scheme DNA à RNA à protein, the ontogene implements the regulation according to the scheme DNA à RNA; and 3) the course of individual development is programmed by double-strand RNAs produced by ontogenes in germline cells .
Waddington, C.H. (1968) Towards a Theoretical Biology: Prolegomena. Edinburgh University Press, Edinburgh.
Waddington, C.H. (1953) Epigenetics and Evolution. Symposia of the Society for Experimental Biology, 7, 186-199.
Belousov, L.V. (2006) A Morphomecanical Aspect of Epigenesis. Genetica (Russ.), 42, 1165-1169.
Chadov, B.F., Chadova, E.V., Kopyl, S.A., Artemova, E.V., Khotskina, E.A. and Fedorova, N.B. (2004) From Genetics of Intraspecific Differences to Genetics of Intraspecific Similarity. Russian Journal of Genetics, 40, 945-958. https://doi.org/10.1023/B:RUGE.0000041372.16880.02
Chadov, B.F. (2015) About the Cause of Systemacy of the Universe and Parts of It. Eco-Potencial, № 2, 124-146. (In Russian)
Chadov, B.F., Fedorova, N.B. and Chadova, E.V. (2015) Conditional Mutations in Drosophila Melanogaster: On the Occasion of the 150th Anniversary of G. Mendel’s Report in Brünn. Mutation Research/Reviews in Mutation Research, 765, 40-55. https://doi.org/10.1016/j.mrrev.2015.06.001
Russo, V.E.A., Martienssen, R.A., Riggs, A.D. and Briggs, A.D., Eds. (1996) Epigenetic Mechanisms of Gene Regulation. Cold Spring Harbor Laboratory Press, New York.
Zakijan, S.M. (2012) Introduction. In: Zakijan, S.M., Vlasov, S.M. and Dement’eva, E.V., Eds., Epigenetics, SD RAN, Novosibirsk, 5-6. (In Russian)
Chadov, B.F. (2015) Modern Metaphysics and the Cyclic Protomodel. Eco-Potential, №4, 53-73. (In Russian)
Chadov, B.F., Chadova, E.V., Kopyl, S.A. and Fedorova, N.B. (2000) A New Class of Mutations in Drosophila melanogaster. Doklady Biological Sciences, 373, 423-426.
Chadov, B.F. (2000) Mutations in the Regulatory Genes in Drosophila Melanogaster. International Conferences on Biodiversity and Dynamics of Ecosystems in North Eurasia, Novosibirsk, 21-26 August 2000, 16-18.
Chadov, B.F. (2005) Features of Intraspecific Similarity and Peculiarities of Mendel’s Approach to Study of Heredity. Philosophy of Science, 26, 94-114. (In Russian)
Chadov, B.F., Chadova, E.V., Kopyl, S.A., Khotskina, E.A. and Fedorova, N.B. (2004) Genes Controlling Development: Morphoses, Phenocopies, Dimorphs and Other Visible Expressions of Mutant Genes. Russian Journal of Genetics, 40, 271-281. https://doi.org/10.1023/B:RUGE.0000021627.82588.41
Chadov, B.F., Chadova and Fedorova, N.B. (2012) Epigenetic Phenomenology in Conditional Mutants of Drosophila melanogaster: Morphoses and Modifications. In: Zakijan, S.M., Vlasov, S.M. and Dement’eva, E.V., Eds., Epigenetics, SD RAN, Novosibirsk, 499-533. (In Russian)
Chadov, B.F. (2005) Ontogenes in Drosophila melanogaster: Genetic Features and Role in Onto- and Phylogenesis. In: Modern Problems of Genetics, Radiobiology, Radioecology and Evolution, 195.
Chadov, B.F. (2006) A New Stage in the Development of Genetics and Term Epigenetics. Russian Journal of Genetics, 42, 1053-1065. https://doi.org/10.1134/S1022795406090110
Chadov, B.F. (2007) Ontogenes in Drosophila melanogaster: Genetic Features and role in Onto- and Phylogeny. In: Korogodina, V.L., Chini, A. and Durante, M., Eds., Modern Problems of Genetics, Radiobiology, Radioecology and Evolution, JINR 1, Dubna, 80-91. (In Russian)
Chadov, B.F., Fedorova, N.B., Chadova, E.V. and Khotskina, E.A. (2011) Conditional Mutations in Drosophila. Journal of Life Sciences (USA), 5, 224-240.
Chadov, B.F., Chadova, E.V., Khotskina, E.A., Artemova, E.V. and Fedorova, N.B. (2004) The Main Effect of Chromosomal Rearrangement Is Changing the Action of Regulatory Genes. Russian Journal of Genetics, 40, 723-731. https://doi.org/10.1023/B:RUGE.0000036520.93159.a5
Chadov, B.F. (2001) Mutations Capable of Inducing Speciation. In: Stegnij, V.N., Ed., Evolution Biology, Tomsk State University Press, 138-162. (In Russian) http://www.evolbiol.ru/
Fedorova, N.B., Khotskina, E.A., Mitrenina, E.Ju. and Chadov, B.F. (2004) Chromosomal Rearrangements and Speciation: Explanation of the Relationship between Events. Vestnik of Tomsk University, № 10, 122-127. (In Russian)
Fedorova, N.B., Khotskina, E.A., Mitrenina, E.Ju. and Chadov, B.F. (2004) Chromosomal Rearrangements and Speciation: Explanation of the Relationship between Events. In: Stegniy, V.N., Ed., Evolution Biology, Tomsk State University, Tomsk 3, 107-120. (In Russian) http://www.evolbiol.ru/large_files/chadov2005.pdf
Fedorova, N.B., Chadova, E.V., Khotskina, E.A. and Chadov, B.F. (2009) Genetic Mutations Preparing the Speciation Process. In: Kunakh, V.A., Ed., Factors of Experimental Evolution of Organisms, Logos, Kiev, 24-29. (In Russian)
Chadov, B.F., Chadova, E.V. and Fedorova, N.B. (2017) A Novel Type of Gene Interaction in D. melanogaster. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 795, 27-30. https://doi.org/10.1016/j.mrfmmm.2017.01.002
Chadov, B.F., Chadova, E.V. and Fedorova, N.B. (2017) A Novel Type of Gene Interaction in D. melanogaster. Mutation Research, 795, 27-30. http://biomedical-advances.org/ep-20175-29/
Fedorova, N.B., Chadova, E.V., Khotskina, E.A. and Chadov, B.F. (2010) Conditional Mutations: Obtainment by the Method of Morphoses. In: Kunakh, V.A., Ed., Topics in Experimental Evolution of Organisms, Logos, Kiev, 78-83. (In Russian)
Chadov, B.F., Chadova, E.V. and Khotskina, E.A. (1986) Chromosome Conjugation in Drosophila. III. Similarity and Differences between Chromosome Pairing in Females and Males. Genetika (Rus), 22, 71-79.
Ashburner, M. (1989) Drosophila. A Laboratory Handbook. Cold Spring Harbor Laboratory Press, New York.
Chadov, B.F., Fedorova, N.B. and Chadova, E.V. (2013) Parental Effects of Conditional Mutations and Their Explanations. Russian Journal of Genetics, 49, 141-150. https://doi.org/10.1134/S1022795413020038
Macgregor, H.C. and Varley, J. (1988) Working with Animal Chromosomes. 2nd Edition, John Wiley & Sons, New York.
Gaginskaya, E., Kulikova, T. and Krasikova, A. (2009) Avian Lampbrush Chromosomes: A Powerful Tool for Exploration of Genome Expression. Cytogenetic and Genome Research, 124, 251-267. https://doi.org/10.1159/000218130
Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E. and Mello, C.C. (1998) Potent and Specific Genetic Interference by Double-Stranded RNA in Caenorhabditis elegans. Nature, 391, 806-811. https://doi.org/10.1038/35888
Matzke, M.A. and Birchler, J.A. (2005) RNAi-Mediated Pathways in the Nucleus. Nature Reviews Genetics, 6, 24-35. https://doi.org/10.1038/nrg1500
Carlson, B.M. (2009) Human Embryology and Developmental Biology. 4th Edition, Mosby, Philadelphia.
Baranov, V.S., Kuznetsova, T.V., Pendina A.A., Efimova, O.A., Fedorova I.D. and Trofimova, I.L. (2012) Epigenetic Mechanisms of Normal and Pathological Human Development. In: Zakijan, S.M., Vlasov, S.M. and Dement’eva, E.V., Eds., Epigenetics, SD RAN, Novosibirsk, 225-266. (In Russian)
Chadov, B.F. (2002) The “Image” of the Regulatory Gene in Experiments with Drosophila. Russian Journal of Genetics, 38, 725-734. https://doi.org/10.1023/A:1016356418121
Khün, A. (1927) Die Pigmentirung von Habrobracon juglandis Ashmed, ihre Pradetermination und ihre Vererbung durch Gene und Plasmon. Nachrichten von der Gesellschaft der Wissenschaften zu Gottingen, Math.-Phys. Klasse, 407.
Khün, A. (1961) Grungriβ der Vererbungslehre. Quelle&Meyer/Heidelberg.
Sokolov, N.N. (1959) Interaction of the Nucleus and Cytoplasm in Remote Hybridization of Animals. Izd. AN SSSR, Moscow. (In Russian)
Sager, R. (1972) Cytoplasmic Genes and Organelles. Elsevier, Amsterdam.
Nusslein-Volhard, Ch. (1995) The Identification on Genes Controlling Development in Flies and Fishes. Nobel Lecture, 8 December 1995, 285-306.
Wieschaus, E. (1995) From Molecular Patterns to Morphogenesis; The Lessons from Drosophila. Nobel Lecture, 8 December 1995, 314-326.
Korochkin, L.I. (2002) Biology of Individual Development (Genetical Aspect). MGU Press, Moscow. (In Russian)