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Sinomenine Purification by Continuous Liquid-Liquid Extraction Process with Centrifugal Extractors

¹ Hunan Zhenqin Pharmaceutical Group Co., Ltd., Huaihua, China
² Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
³ Hunan Zhenqin Pharmaceutical Group Co., Ltd., Huaihua, China
⁴ Hunan Zhenqin Pharmaceutical Group Co., Ltd., Huaihua, China
⁵ Hunan Zhenqin Pharmaceutical Group Co., Ltd., Huaihua, China
⁶ Hunan Zhenqin Pharmaceutical Group Co., Ltd., Huaihua, China
⁷ Hunan Zhenqin Pharmaceutical Group Co., Ltd., Huaihua, China
⁸ Hunan Zhenqin Pharmaceutical Group Co., Ltd., Huaihua, China
⁹ Hunan Zhenqin Pharmaceutical Group Co., Ltd., Huaihua, China
¹⁰ Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

Advances in Chemical Engineering and Science·Volume 10 (2020)·Pages 171–180·Published 13 May 2020·DOI10.4236/aces.2020.103012

Abstract

Continuous manufacturing is considered as one of the future trends of pharmaceutical engineering. In this work, continuous liquid-liquid extraction for sinomenine purification was realized with the usage of centrifugal extractors. Chloroform was used as the extractant because of the high distribution coefficient (>100). Higher extraction ratio can be obtained when using the centrifugal extractor of Model CWL50-N. The extraction ratio of the second-stage extraction was higher than that of the first-stage extraction. The extraction ratio of the second-stage countercurrent extraction was higher than that of second-stage cross-flow extraction. When chloroform phase was recycled for liquid-liquid extraction, the extraction ratio was also higher than 95%. This work can also be an example of continuous liquid-liquid extraction for the separation of other Chinese medicine components.

KeywordsSinomenineContinuous ManufacturingLiquid-Liquid ExtractionCentrifugal Extractor

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Sinomenine Purification by Continuous Liquid-Liquid Extraction Process with Centrifugal Extractors

Abstract

References (14)