Low Molecular Weight Poly(Lactide-<i>co</i>-Caprolactone) for Tissue Adhesion and Tetracycline Hydrochloride Controlled Release in Wound Management
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Abstract
The use of biopolymers as bioadhesives for human tissue is becoming a preferred alternative to suturing due to their superior adhesive, biocompatible, and biodegradable properties. In this work, low molecular weight poly(L-lactide-co- ε -caprolactone) (P(LA- co -CL) was synthesized to achieve the glass transition temperature (T g ) of the copolymer at ambient temperature so that during application on the skin, the copolymer when combined with chitosan (CHI) into the CHI/P(LA- co -CL) film could provide the strong support at the injury site. Using alcohols with different numbers of hydroxyl groups as the co-initiator in polymerization provided the distinctive characteristics of copolymers. Among all copolymers synthesized, P(LA- co -CL) copolymer using pentaerythritol as the co-initiator when combined with CHI at the ratio of copolymer/CHI at 70/30 yielded the good film properties in tissue adhesion and tetracycline hydrochloride release.
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