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Synthesis and Enhanced Guest-Binding Affinities of Dendrimer-Based Cyclophane Tetramer and Octamer
Department of Chemistry, Faculty of Science, Fukuoka University, Fukuoka, Japan
- 1 Department of Chemistry, Faculty of Science, Fukuoka University, Fukuoka, Japan
- 2
- 3
Advances in Chemical Engineering and Science·Volume 03 (2013)·Pages 33–37·Published 12 July 2013·DOI10.4236/aces.2013.33A1004
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Abstract
Dendritic cyclophane tetramer and octamer were prepared by aminolysis of succinimidyl ester derivative of tetraaza [ 6.1.6 .1] paracyclophane with the corresponding poly(amidoamine) dendrimers as a scaffold, followed by removal of the protecting groups. The present cyclophane tetramer and octamer showed enhanced guest-binding affinities toward fluorescent guests such as 6- p -toluidinonaphthalene-2-sulfonate and 6-anilinonaphthalene-2-sulfonate, in comparison with those of monocyclic cyclophane, reflecting multivalency effects in macrocycles.
KeywordsCyclophane OligomerHost-Guest ChemistryMultivalency Effect
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