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Solventless Organic Reactive Crystallization at Mild Conditions
Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan
Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan
Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan
- 1 Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan
- 2 Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan
- 3 Department of Chemistry and Bioengineering, Iwate University, Morioka, Japan
Advances in Chemical Engineering and Science·Volume 05 (2015)·Pages 461–464·Published 25 August 2015·DOI10.4236/aces.2015.54047
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Abstract
Solid state mixtures of two reactants, 2-hydroxy-1-naphthaldehyde and 2-aminobenzonitrile, were melted at a temperature even lower than both the melting points. And dehydration condensation reaction occurred in the melt to give reaction product N-(2-cyanophenyl)-2-hydroxy-1-naphthadimine. Since the melting point of the product was higher than the reactants, self-crystallization of the product occurred. Usefulness of this one-pot synthesis and crystallization method for industrial application was described.
KeywordsReactionCrystallizationPolymorphismDehydration Condensation
- Cincic, D., Brekalo, I. and Kaitner, B. (2012) Solvent-Free Polymorphism Control in a Covalent Mechanochemical Reaction. Crystal Growth & Design, 12, 44-48. http://dx.doi.org/10.1021/cg2013705
- Huskic, I., Halasz, I., Friscic, T. and Vancika, H. (2012) Mechanosynthesis of Nitrosobenzenes: A Proof-of-Principle Study in Combining Solvent-Free Synthesis with Solvent-Free Separations. Green Chemistry, 14, 1597-1600. http://dx.doi.org/10.1039/c2gc35410a
- Trzesowska-Kruszynska, A. (2013) Solvent-Free and Catalysis-Free Approach to the Solid State in Situ Growth of Crystalline Isoniazid Hydrazones. Crystal Growth & Design, 13, 3892-3900. http://dx.doi.org/10.1021/cg400529s