This study was conducted at University of Gujrat during 2014-2015 as a term paper for Master of Philosophy. The data regarding effect of ozone depletion on human was reviewed and compiled as a review paper from various published articles of international reputed journals, annual/environmental reports of recognized organization and e-books. The causes, mechanism and bio-effects of ozone layer depletion on humans were addressed. It is revealed that introduction of Chloroflourocarbons (CFCs) in the environment is the most rated cause of said depiction. Ozone depletion is allowing the UV radiation to earth surface. The exposure to these radiations is severely affecting all life forms on earth, especially the humans. Permanent or temporary blindness, skin cancer and immunity suppression are the main effects of these radiations reported by various researchers on humans. The prospects of ozone recovery are still undiscovered. The current situation of ozone depiction demands urgent remedial measures to protect lives on this earth.
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