Isolation of Mannooligosaccharides Corresponding to Antigenic Determinants of Pathogenic Yeast <i>Candida catenulata</i> Cell Wall Mannan — Oak Academic Publishing
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Isolation of Mannooligosaccharides Corresponding to Antigenic Determinants of Pathogenic Yeast <i>Candida catenulata</i> Cell Wall Mannan
Laboratory of Microbiology, Faculty of Pharmaceutical Science, Nagasaki International University, Sasebo, Nagasaki, Japan
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1 Laboratory of Microbiology, Faculty of Pharmaceutical Science, Nagasaki International University, Sasebo, Nagasaki, Japan
To investigate the chemical structure of cell wall mannan of pathogenic yeast, Candida catenulata IFO 0745 strain, which possess the epitopes of antigenic factors 1, 9, and 34 to genus Candida , we previously performed the two-dimensional nuclear magnetic resonance (NMR) analysis of this mannan, Fr. C, without the need for harsh procedures. In this study, three oligosaccharides, biose, triose, and tetraose, and mannose were isolated from Fr. C by acetolysis. The results of NMR analysis indicate that the chemical structures of these oligosaccharides were identified to Man α 1-2Man, Man α 1-2Man α 1-2Man, and Man α 1-3Man α 1-2Man α 1-2Man. The most of resultant mannose seems to be originated from the α -1,6-linked mannan backbone which is recognized by antiserum to factor 9. The inhibition assay of slide agglutination reaction between Fr. C and antigenic antibodies using three oligosaccharides indicate that the Man α 1 - 2Man α 1-2Man and Man α 1-3Man α 1-2Man α 1-2Man possess domains corresponding to immunodominants of antigenic factors 1 and 34, respectively.
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