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Dynamism of Antimicrobial Activity of Actinomycetes—A Case Study from Undisturbed Microbial Niche
National Innovation Foundation India, Satellite Complex, Nr. Mansi Circle, Ahmedabad, Gujarat, India
Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
National Innovation Foundation India, Satellite Complex, Nr. Mansi Circle, Ahmedabad, Gujarat, India
Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
National Innovation Foundation India, Satellite Complex, Nr. Mansi Circle, Ahmedabad, Gujarat, India
- 1 National Innovation Foundation India, Satellite Complex, Nr. Mansi Circle, Ahmedabad, Gujarat, India
- 2 Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
- 3 Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
- 4 Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
- 5 Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
- 6 Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
- 7 Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
- 8 Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
- 9 National Innovation Foundation India, Satellite Complex, Nr. Mansi Circle, Ahmedabad, Gujarat, India
- 10 Sadbhav SRISTI Sanshodhan Laboratory, AES Boys Hostel Campus, Nr. Gujarat University Library & SBI Bank, Navrangpura, Ahmedabad, Gujarat, India
- 11 National Innovation Foundation India, Satellite Complex, Nr. Mansi Circle, Ahmedabad, Gujarat, India
Advances in Microbiology·Volume 04 (2014)·Pages 324–334·Published 9 May 2014·DOI10.4236/aim.2014.46039
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Abstract
Escalation of drug resistant microbes (bacteria) had forced researchers to search new and improved therapeutic compounds from different possible sources, including metabolites secreted by the actinomycetes. The aim of this study was to evaluate the pattern of antimicrobial actinomycetes from physiologically distinct soil of different geographical locations. Forty five soil samples were collected from 5 districts of Gujarat including two sanctuaries as source of survey for bioactive actinomycetes. Crowded plate technique was used for isolation and Agar cylinder method was employed for the antimicrobial screening. A total of 171 actinomycetes were isolated and screened against eighteen pathogens responsible for causing diseases in plants and humans. Results indicate that 79% of the isolates were active against at least one of the eighteen tested pathogens. Some of the actinomycetes strain had shown strong antibacterial and antifungal activity which may be a good source of obtaining novel antimicrobials.
KeywordsActinomycetesScreeningAntimicrobialDrug ResistanceSoil Microflora
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