Malignant external otitis is a severe infection of the external auditoy canal, characterized by high gravity and mortality. It can arrive to skull base and originate intracranial complications. The most frequent pathogenic agent is Pseudomonas aeruginosa . Authors described two cases of external malignant otitis caused by Staphylococcus aureus , explaining clinical features, progression, diagnostic and therapeutic approach, prognosis of this disease. A comparison between Pseudomonas aeruginosa and Staphylococcus aureus malignant otitis was described, associated with a literature analysis.
Hobson, C.E., Moy, J.D., Byers, K.E., Raz, Y., Hirsch, B.E. and McCall, A.A. (2014) Malignant Otitis Externa: Evolving Pathogens and Implications for Diagnosis and Treatment. Otolaryngology—Head and Neck Surgery, 151, 112-116.
Carfrae, M.J. and Kesser, B.W. (2008) Malignant Otitis Externa. Otolaryngologic Clinics of North America, 41, 537-549.
Grandis, J.R., Branstetter IV, B.F. and Yu, V.L. (2004) The Changing Face of Malignant (Necrotising) External Otitis: Clinical, Radiological, and Anatomic Correlations. The Lancet Infectious Diseases, 4, 34-39. http://dx.doi.org/10.1016/S1473-3099(03)00858-2
Ophir, H., et al. (2003) Necrotizing (Malignant) External Otitis. American Family Physician, 68, 309-312.
Keay, D.G. and Murray, J.A. (1988) Malignant Otitis Externa Due to Staphylococcus Infection. The Journal of Laryngology & Otology, 102, 926-927. http://dx.doi.org/10.1017/S0022215100106826
Barrow, H.N. and Levenson, M.J. (1992) Necrotizing “Malignant” External Otitis Caused by Staphylococcus epidermidis. Otolaryngology—Head and Neck Surgery, 118, 94-96. http://dx.doi.org/10.1001/archotol.1992.01880010098023
Soldati, D., Mudry, A. and Monnier, P. (1999) Necrotizing Otitis Externa Caused by Staphylococcus epidermidis. European Archives of Oto-Rhino-Laryngology, 256, 439-441. http://dx.doi.org/10.1007/s004050050184
Thompson, A.C., et al. (2010) Necrotising Otitis Externa: An Unusual Cause of Cranial Nerve Palsy in a Diabetic Haemodialysis Patient. The Journal of the Royal College of Physicians of Edinburgh, 40, 26-28. http://dx.doi.org/10.4997/JRCPE.2010.106
Garcia Rodriguez, J.A., et al. (1992) A Case of Malignant External Otitis Involving Klebsiella oxytoca. The Journal of the Royal College of Physicians of Edinburgh, 11, 75-77. http://dx.doi.org/10.1007/BF01971280
Parize, P., Chandesris, M.O., Lanternier, F., Poirée, S., Viard, J.P., Bienvenu, B., et al. (2009) Antifungal Therapy of Aspergillus fumigatus Invasive Otitis Externa: Efficacy of Voriconazole and Review. Antimicrobial Agents and Chemotherapy, 53, 1048-1053.
Tarazi, A.E., Al-Tawfiq, J.A. and Abdi, R.F. (2012) Fungal Malignant Otitis Externa: Pitfalls, Diagnosis, and Treatment. Otology & Neurotology, 33, 769-773. http://dx.doi.org/10.1097/MAO.0b013e3182565b46
Clark, J.H., Lin, F.R., Salaria, S.N., Stewart, C.M. and Francis, H.W. (2011) Malignant Otitis Externa Caused by Aspergillus Fumigatus: A Case Report. Otology & Neurotology, 32, e22-e23. http://dx.doi.org/10.1097/MAO.0b013e3181e3dec7
Loh, S. and Loh, W.S. (2013) Malignant Otitis Externa: An Asian Perspective on Treatment Outcomes and Prognostic Factors. Otolaryngology—Head and Neck Surgery, 148, 991-996. http://dx.doi.org/10.1177/0194599813482107
Franco-Vidal, V., Blanchet, H., Bebear, C., Dutronc, H. and Darrouzet, V. (2007) Necrotizing External Otitis: A Report of 46 Cases. Otology & Neurotology, 28, 771-773. http://dx.doi.org/10.1097/MAO.0b013e31805153bd
Mani, N., Sudhoff, H., Rajagopal, S., Moffat, D. and Axon, P.R. (2007) Cranial Nerve Involvement in Malignant External Otitis: Implications for Clinical Outcome. Laryngoscope, 117, 907-910. http://dx.doi.org/10.1097/MLG.0b013e318039b30f
Clerc, N.L., Verillaud, B., Duet, M., Guichard, J., Herman, P. and Kania, R. (2014) Skull Base Osteomyelitis: Incidence of Resistance, Morbidity and Treatment Strategy. Laryngoscope, 124, 2013-2016. http://dx.doi.org/10.1002/lary.24726
Soudry, E., Hamzany, Y., Preis, M., Joshua, B., Hadar, T. and Nageris, B.I. (2011) Malignant External Otitis: Analysis of Severe Cases. Otolaryngology—Head and Neck Surgery, 144, 758-762. http://dx.doi.org/10.1177/0194599810396132
Chakraborty, D., Bhattacharya, A., Gupta, A.K., Panda, N.K., Das, A. and Mittal, B.R. (2013) Skull Base Osteomyelitis in Otitis Externa: The Utility of Triphasic and Single Photon Emission Computed Tomography/Computed Tomography Bone Scintigraphy. Indian Journal of Nuclear Medicine, 28, 65-69.
Chakraborty, D., Bhattacharya, A., Kamaleshwaran, K.K., Agrawal, K., Gupta, A.K. and Mittal, B.R. (2012) Single Photon Emission Computed Tomography/Computed Tomography of the Skull in Malignant Otitis Externa. American Journal of Otolaryngology, 33, 128-129. http://dx.doi.org/10.1016/j.amjoto.2011.05.002
Sardesai, R.B. and Krishnakumar, T. (2002) Malignant Otitis External—Our Experience. Indian Journal of Otolaryngology and Head & Neck Surgery, 54, 132-135.
Bernheim, J. and Sade, J. (1989) Histopathology of the Soft Parts in 50 Patients with Malignant External Otitis. Journal of Laryngology & Otology, 103, 366-368. http://dx.doi.org/10.1017/S0022215100108977
Karantanas, A.H., Karantzas, G., Katsiva, V., Proikas, K. and Sandris, V. (2003) CT and MRI in Malignant External Otitis: A Report of Four Cases. Computerized Medical Imaging and Graphics, 27, 27-34. http://dx.doi.org/10.1016/S0895-6111(02)00052-6
Yang, T.H., Kuo, S.T. and Young, Y.H. (2006) Necrotizing External Otitis in a Patient Caused by Klebsiela pneumoniae. European Archives of Oto-Rhino-Laryngology and Head & Neck, 263, 344-346. http://dx.doi.org/10.1007/s00405-005-0998-y
Shimizu, T., Ishinaga, H., Seno, S. and Majima, Y. (2005) Malignant External Otitis: Treatment with Prolonged Usage of Antibiotics and Burow’s Solution. Auris Nasus Larynx, 32, 403-406. http://dx.doi.org/10.1016/j.anl.2005.05.010
Shichmanter, R., Miller, E.B. and Landau, Z. (2004) Adverse Drug Reactions Due to Prolonged Therapy for Malignant External Otitis. European Journal of Internal Medicine, 15, 441-445. http://dx.doi.org/10.1016/j.ejim.2004.08.006
Narozny, W., Kuczkowski, J., Stankiewicz, C., Kot, J., Mikaszewski, B. and Przewozny, T. (2006) Value of Hyperbaric Oxygen in Bacterial and Fungal Malignant External Otitis Treatment. European Archives of Oto-Rhino-Laryngology and Head & Neck, 263, 680-684. http://dx.doi.org/10.1007/s00405-006-0033-y
Tisch, M., Lorenz, K.J., Harm, M., Lampl, L. and Maier, H. (2003) The Treatment of Necrotizing Otitis Externa with a Combination of Surgery, Antibiotics, Specific Immunoglobulins and Hyperbaric Oxygen Therapy. Results of the Ulm Treatment Concept. Journals of Otolaryngology Head and Neck Surgery, 51, 315-320.