Comparative Analysis <i>in Vitro</i> of the Application of blue^®m Oral Gel versus Chlorhexidine on <i>Porphyromonas gingivalis</i>: A Pilot Study

Abstract

Oxygen is an essential nutrient for cellular metabolism, especially energy production. The substance is involved in multiple processes including oxidative killing of bacteria, reepithelialization, angiogenesis, and collagen synthesis. In order to test and compare the effects of the oxygen gel blue &reg; m in vitro on Porphyromonas gingivalis , four groups were evaluated: 100% oxygen gel (B1), 75% oxygen gel (B2), 50% oxygen gel (B3), and 100% 0.12% chlorhexidine digluconate solution (C1). For this purpose, evaluations of the proportion of bacterial growth were performed, using the Agar diffusion test. The results demonstrated that blue &reg; m at a dose of 100% and 75% is similar to chlorhexidine (p > 0.05); however blue &reg; m at a concentration of 50% showed a lower inhibition halo when compared to chlorhexidine (p = 0.024). blue &reg; m at higher concentrations provided inhibitory halo of Porphyromonas gingivalis similar to chlorhexidine digluconate, while blue &reg; m at lower concentration had a lower bacterial inhibition halo compared to chlorhexidine.