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Synthesis, Characterization and Bioactivity of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane
Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Port Harcourt, Nigeria
Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Port Harcourt, Nigeria
Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Port Harcourt, Nigeria
Department of Pure and Industrial Chemistry, University of Port Harcourt, Port Harcourt, Nigeria
- 1 Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Port Harcourt, Nigeria
- 2 Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Port Harcourt, Nigeria
- 3 Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Port Harcourt, Nigeria
- 4 Department of Pure and Industrial Chemistry, University of Port Harcourt, Port Harcourt, Nigeria
American Journal of Analytical Chemistry·Volume 11 (2020)·Pages 261–268·Published 3 June 2020·DOI10.4236/ajac.2020.116020
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Abstract
This study reports the synthesis of 1,1-bis(2-Carbamoylguanidino)furan-2-ylmethane, characterisation and bioactivities on selected microorganism. The first step involves the coupling of furfural with urea to obtain 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea, which was subsequently refluxed with more urea in ethanol for 1 hour to afford the product. Both intermediate and product were characterized by GC-MS, IR, 1 H-NMR, 13 C-NMR. The synthesized compound1,1-bis(2-carbamoylguanidino)furan-2-ylmethane was bioactive on Escherichia coli, Salmomellatyphi and Bacillus subtilis to different extent and is inactive on Staphylococcus aureus. The presences of bioactive moieties and pharmacological activities have proved the potency of furfural derivatives in the development of novel drug in future.
KeywordsFurfural11-bis(2-Carbamoylguanidino)furan-2-ylmethaneBioactivity
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