Research ArticleOpen AccessGoogle Scholar indexed
Synthesis and Bioactivity of 1-((2-Carbamoylguanidino) (furan-2-ylmethyl)urea
Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Nigeria
Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Nigeria
Department of Pure and Industrial Chemistry, University of Port Harcourt, Port Harcourt, Nigeria
Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Nigeria
- 1 Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Nigeria
- 2 Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Nigeria
- 3 Department of Pure and Industrial Chemistry, University of Port Harcourt, Port Harcourt, Nigeria
- 4 Department of Science Laboratory Technology, Captain Elechi Amadi Polytechnic, Rumuola, Nigeria
American Journal of Analytical Chemistry·Volume 11 (2020)·Pages 280–288·Published 7 July 2020·DOI10.4236/ajac.2020.117022
Copy link · social · email
Abstract
1-((2-Carbamoylguanidino)(furan-2-ylmethyl)urea was synthesised by coupling purified furfural with urea. The compound was characterized by GC-MS, FTIR, and 1 H-NMR. The pathogens, Escherichia coli , Salmonella typhi , Staphylococcus aureus and Bacillus subtilis were isolated and screened with different concentrations of 1-((2-carbamoylguanidino)(furan-2-ylmethyl)urea. All the pathogens were susceptible to the synthesized compound except Bacillus subtilis. Due to this broad spectrum of activity, 1-((2-Carbamoylguanidino)(furan-2-ylmethyl))urea) can be use for various medicinal purposes and is therefore encouraged for the development of a novel drug in future.
KeywordsFurfural1-((2-Carbamoylguanidino)(furan-2-ylmethyl)ureaBioactivity
- Maria, M. (2017) 2-Aminopyridine—A Classic and Trendy Pharmacophore. International Journal of Pharma and Bioscience, 8, 338-355. https://doi.org/10.22376/ijpbs.2017.8.2.p338-355
- Dueke-Eze, C.U., Fasina, T.M. and Mphahlele, M. (2013) Synthesis, Characterization and Solvent Effects on the Electronic Absorption Spectra of Aminopyridine Schiff Bases. Asian Journal of Chemistry, 25, 8505-8508. https://doi.org/10.14233/ajchem.2013.14805
- Ananthalakshmi, S.K., Kiriethika, R.A. and Kalavani, A. (2014) Synthesis, Characterization and Antimicrobial Studies of Tosyl Ester of Carboxylic Acid. International Journal of Scientific and Research Publication, 4, 1-14.
- Nagashree, M.P., Mallesha, L. and Bindya, R. (2015) Antimicrobial Activity of Methyl-3-aminopyridine-4-carboxylate Derivatives. Hindawi Journal of Chemistry, 5, 700-705.
- Tayebee, R. and Nehzat, F. (2012) A Simple and Effective Methodology for Sulfonylation of Alcohol and Aniline under Solvent-Free Condition at Room Temperature. American Journal of Medicine and Medical Sciences, 2, 36-39. https://doi.org/10.5923/j.ajmms.20120201.08
- Döbereine, J.W. (1832) Ueber die medicinische und Chemische Anwendung und die vortheilhafte darstellung der Ameisensäure. Berichte der deutschen chemischen Gesellschaft, 3, 141-146. https://doi.org/10.1002/jlac.18320030206
- Ngochindo, R.I. (1995) Furfural in a Developing Economy. Rhomers System, Eleme, Rivers State, Nigeria.
- Machado, G., Leon, S., Santos, F., Lourega, R., Dullius, J., Mollmann, M.F. and Eichler, P. (2016) Literature Review on Furfural Production from Lignocellulosic Biomass. Natural Resources, 7, 115-129. https://doi.org/10.4236/nr.2016.73012
- Eseyin, E.A. and Steele, P.S. (2015) An Overview of the Application of Furfural and Its Derivatives. International Journal of Advanced Chemistry, 3, 42-47. https://doi.org/10.14419/ijac.v3i2.5048
- Rodriguez-Kabana, R., Kloepper, J.W., Weaver, C.F. and Robertson, D.G. (1993) Control of Plant-Parasitic Nematodes with Furfural—A Naturally Occurring Fumigant. Nematropica, 23, 63-73.
- Zeitsch, K.J. (2000) The Chemistry and Technology of Furfural and Its Many By-Product. Sugar Series, 13, 12-23.
- Yen, K., Iva, G., Lafleur, T. and Jarvis, C. (2014) Production, Properties and Catalytic Hydrogenation of Furfural to Fuel Additive and Value Added Chemicals. Renewable and Sustainable Energy Reviews, 38, 663-676. https://doi.org/10.1016/j.rser.2014.07.003