HPLC Profiling for Quality Control of Secondary Metabolites of Aqueous and Hydroethanolic Extract of <i>Gardenia aqualla Stapf & Hutch</i> — Oak Academic Publishing
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HPLC Profiling for Quality Control of Secondary Metabolites of Aqueous and Hydroethanolic Extract of <i>Gardenia aqualla Stapf & Hutch</i>
Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
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Laboratory of Water and Food Analysis, National Laboratory of Public Health, Abidjan, Côte d’Ivoire
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Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
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Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
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Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
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Faculty of Sciences, Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaoundé 1, Yaoundé, Cameroon
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Department of Analytical, Mineral and General Chemistry, Food Technology, Training and Research Unit, Pharmaceutical and Biological Sciences, Félix Houphouet-Boigny University, Abidjan, Côte d’Ivoire
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Department of Analytical, Mineral and General Chemistry, Food Technology, Training and Research Unit, Pharmaceutical and Biological Sciences, Félix Houphouet-Boigny University, Abidjan, Côte d’Ivoire
1 Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
2 Laboratory of Water and Food Analysis, National Laboratory of Public Health, Abidjan, Côte d’Ivoire
3 Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
4 Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
5 Higher Institute of Health Sciences, Université des Montagnes, Bangangté, Cameroon
6 Faculty of Sciences, Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaoundé 1, Yaoundé, Cameroon
7 Department of Analytical, Mineral and General Chemistry, Food Technology, Training and Research Unit, Pharmaceutical and Biological Sciences, Félix Houphouet-Boigny University, Abidjan, Côte d’Ivoire
8 Department of Analytical, Mineral and General Chemistry, Food Technology, Training and Research Unit, Pharmaceutical and Biological Sciences, Félix Houphouet-Boigny University, Abidjan, Côte d’Ivoire
WHO strategy on traditional medicine is based on security and quality of phytomedicine. Commonly adulterated affecting mostly metabolic and sexual dysfunction drugs. Control quality of those phytomedicines requires development of strategy and techniques applicable to them. Among the techniques, Reverse Phase Liquid Chromatography is the most used and has been developed in these studies to assess a protocol to characterize Gardenia aqualla leaves extract. The method consists in determining chromatographic conditions using organic and pH gradient models based on water and acetonitrile combined with pH modifiers made up of formic acid (AF) and ammonium hydroxide (NH 3 ). Results show that extracts contain mainly acidic compounds quickly eluted by NH 3 and more retained by AF. Optimal pH range for separation is 3 - 7 corresponding to 1.59 mM of NH 3 and 6.55 mM of AF. In these conditions, elution of many polar compounds could be effective using a C18 based-deactivated column in a short period of time.
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