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Audit of the Physico-Chemical Quality of Amoxicillin Based Drugs Marketed in Senegal
Faculty of Medicine, Pharmacy and Odonto-Stomatology, University Cheik Anta DIOP Dakar, Dakar, Sénégal
National Health Laboratory of Mali, Bamako, Mali
Faculty of Pharmacy of Bamako, University of Technical and Technological Sciences of Bamako (FAPH/USTTB), Bamako, Mali
National Drug Control Laboratory of Senegal (LNCM), Dakar, Sénégal
Faculty of Pharmacy of Bamako, University of Technical and Technological Sciences of Bamako (FAPH/USTTB), Bamako, Mali
Faculty of Pharmacy of Bamako, University of Technical and Technological Sciences of Bamako (FAPH/USTTB), Bamako, Mali
Faculty of Pharmacy of Bamako, University of Technical and Technological Sciences of Bamako (FAPH/USTTB), Bamako, Mali
National Drug Control Laboratory of Senegal (LNCM), Dakar, Sénégal
National Health Laboratory of Mali, Bamako, Mali
National Drug Control Laboratory of Senegal (LNCM), Dakar, Sénégal
- 1 Faculty of Medicine, Pharmacy and Odonto-Stomatology, University Cheik Anta DIOP Dakar, Dakar, Sénégal
- 2 National Health Laboratory of Mali, Bamako, Mali
- 3 Faculty of Pharmacy of Bamako, University of Technical and Technological Sciences of Bamako (FAPH/USTTB), Bamako, Mali
- 4 National Drug Control Laboratory of Senegal (LNCM), Dakar, Sénégal
- 5 Faculty of Pharmacy of Bamako, University of Technical and Technological Sciences of Bamako (FAPH/USTTB), Bamako, Mali
- 6 Faculty of Pharmacy of Bamako, University of Technical and Technological Sciences of Bamako (FAPH/USTTB), Bamako, Mali
- 7 Faculty of Pharmacy of Bamako, University of Technical and Technological Sciences of Bamako (FAPH/USTTB), Bamako, Mali
- 8 National Drug Control Laboratory of Senegal (LNCM), Dakar, Sénégal
- 9 National Health Laboratory of Mali, Bamako, Mali
- 10 National Drug Control Laboratory of Senegal (LNCM), Dakar, Sénégal
American Journal of Analytical Chemistry·Volume 14 (2023)·Pages 351–361·Published 21 September 2023·DOI10.4236/ajac.2023.149019
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Abstract
Non-compliant antibiotics pose problems of therapeutic efficacy at the level of the individual, but also a serious public health problem. The objective of our study was to evaluate the quality of generic amoxicillin (42 samples) by analytical methods in Dakar/Senegal. At 100% visual inspection of compliance; 100% compliance uniformity test; at the dissolution test all > 80% (86.8% to 108.8%). The presence of amoxicillin with the following contents: Tablets (95.2% to 104.1%); Capsules (91.5% to 113.9%) and Suspensions drinkable (96.9% - 118.7%). All the samples in our study are 100% compliant according to the European and American pharmacopoeias (90% - 120%). Other studies should therefore be oriented in the direction of stability as well as the dosage of degradation products.
KeywordsQuality ControlAmoxicillinAnalytical Methods
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