Use of Cucurbit [6] Uril as a Modifier in the Electrochemical Determination of Antitumor Platinum (II) Complex: <i>Trans</i>-[PtCl<sub>2</sub>(Dimethylamine) (Isopropylamine)]. Application to Biological Samples — Oak Academic Publishing
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Use of Cucurbit [6] Uril as a Modifier in the Electrochemical Determination of Antitumor Platinum (II) Complex: <i>Trans</i>-[PtCl<sub>2</sub>(Dimethylamine) (Isopropylamine)]. Application to Biological Samples
Departamento de Química Analítica y Análisis Instrumental, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
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Departamento de Química Analítica y Análisis Instrumental, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
1 Departamento de Química Analítica y Análisis Instrumental, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
2 Departamento de Química Analítica y Análisis Instrumental, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
A square wave voltammetry (DPV) method for trans -Pt[Cl 2 (Dimethylamine)(isopropylamine)] determination is developed. To this end, all the chemical and instrumental variables affecting the determination of trans -Pt[Cl 2 (Dimethylamine) (isopropylamine)] are optimized. From studies of the mechanisms governing the electrochemical response of trans- Pt[Cl 2 (Dimethylamine)(isopropylamine)], it was concluded that it was an electrochemically reversible system with a n adsorptive oxidation phenomenon. Under optimal conditions, the variation of analytical signal (Ip) with trans- Pt[Cl 2 (Dimethylamine)(isopropylamine)] concentration was linear in the 0.05 μg · mL - 1 to 10 μg · mL - 1 range, with a LOD 91 μg · mL - 1 of and a LOQ of 303 μg · mL - 1 , a RSD 1 . 10% and Er 0.72%. The optimized method was applied to the determination of trans -Pt[Cl 2 (Dimethylamine)(isopropylamine)] in biological fluids, in human urine and synthetic urine.
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