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Thermal Decomposition of Some Cardiovascular Drugs (Telmisartane, Cilazapril and Terazosin HCL)
Chemistry Department, Faculty of Science, King AbdulAziz University, Jeddah, KSA
Chemistry Department, Faculty of Science, King AbdulAziz University, Jeddah, KSA
Chemistry Department, Faculty of Science, King AbdulAziz University, Jeddah, KSA
National Organization for Drug Control and Research, Cairo, Egypt
- 1 Chemistry Department, Faculty of Science, King AbdulAziz University, Jeddah, KSA
- 2 Chemistry Department, Faculty of Science, King AbdulAziz University, Jeddah, KSA
- 3 Chemistry Department, Faculty of Science, King AbdulAziz University, Jeddah, KSA
- 4 National Organization for Drug Control and Research, Cairo, Egypt
American Journal of Analytical Chemistry·Volume 04 (2013)·Pages 337–342·Published 15 July 2013·DOI10.4236/ajac.2013.47042
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Abstract
Thermal analysis of some antihypertensive drugs, Telmisartan, Cilazapril and Terazosin HCL was achieved. Thermo gravimetry, derivative thermogravimetry and differential thermal analysis were used through the work. Thermogravim etric parameters such as activation energy, frequency factor and reaction order were calculated. The results show the stability value decrease in the order Telmisartan > Cilazapril > Terazosin. This method can be used in the quality con trol of pharmaceutical compounds because it is simple, fast and cheap .
KeywordsAnti-Hypertensive DrugsQuality ControlThermal AnalysisThermogravimetryDerivative ThermogravimetryDifferential Thermal Analysis
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