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Determination of Meclofenoxate Content in Meclofenoxate Hydrochloride for Injection by DSC and <sup>1</sup>H-NMR
School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, China
Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, China
Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
- 1 School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, China
- 2 Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
- 3 Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
- 4 School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, China
- 5 Laboratory of Pharmaceutical Analysis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
American Journal of Analytical Chemistry·Volume 07 (2016)·Pages 92–98·Published 15 January 2016·DOI10.4236/ajac.2016.71009
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Abstract
Two simple and rapid analytical methods (DSC and 1 H-NMR), are proposed for determination of meclofenoxate in meclofenoxate hydrochloride for injection. DSC thermogram is recorded without any sample pretreatment. The response linearity is ensured by linear determination factors R 2 , which is 0.9982. The recoveries of meclofenoxate hydrochloride in sterile powder for injection are from 98.3% to 102.3% (n = 3). The quantitative 1 H-NMR is quick and simple to use. The quantitation of meclofenoxate is reproducible and the relative standard deviation is 1.0%. The accuracy of two methods is validated by comparison with the results obtained by HPLC. The results show that the two methods are capable of quantifying the content of meclofenoxate in meclofenoxate hydrochloride for injection.
KeywordsMeclofenoxate HydrochlorideDSC<sup>1</sup>H-NMRAnalysis
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