Synthesis, Characterization and Antimicrobial Activity of Schiff Base (<i>E</i>)-<i>N</i>-(4-(2-Hydroxybenzylideneamino) Phenylsulfonyl) Acetamide Metal Complexes — Oak Academic Publishing
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Synthesis, Characterization and Antimicrobial Activity of Schiff Base (<i>E</i>)-<i>N</i>-(4-(2-Hydroxybenzylideneamino) Phenylsulfonyl) Acetamide Metal Complexes
Department of Basic Science, Faculty of Engineering Science, Sinai University, Arish, Egypt
,
Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt
,
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, Arish, Egypt
1 Department of Basic Science, Faculty of Engineering Science, Sinai University, Arish, Egypt
2 Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt
3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, Arish, Egypt
New series of Ag, Cd(II), Ce(III), Co(II), Cr(III), Fe(III), Ni(II) and Pb(II) complexes with ( E )- N -(4-(2- hydroxybenzylideneamino) phenylsulfonyl) {S.S} have been synthesized. These compounds have been characterized by different physico-chemical techniques like, melting point, elemental analysis, FT-IR, UV spectroscopy, 1 H NMR spectroscopy, conductance measurements, magnetic susceptibility and mass spectral analysis. The metal ions concentrations have been determined using inductively coupled plasma mass spectrometry (ICP-MS). Spectroscopic studies suggest coordination most of complexes in a regular octahedral arrangement in 2L:1M molar ratio by two N azomethine and two OH phenolic from Schiff base {S.S} in the form of [ML 2 (H 2 O) 2 ], M metal, L ligand {S.S}. Complexes have been screened for their antibacterial {Gram negative bacteria ( Escherichia coli and Pseudomonas aeruginosa )}, {Gram positive bacteria ( Bacillus subtilis and Sterptococcus pneumoniae )} and antifungal ( Aspergillus fumigates and Candida albicans ) showing promising antimicrobial biological activity.
KeywordsBiological ActivityInductively Coupled PlasmaSynthesisSulfacetamideTransition Metal Complexes
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