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Carobomer Based Controlled Release Designs of Atorvastatin Calcium Tablets Evaluated Using Quality by Design (QbD) Approach
Sri Krishnadevaraya University, Anantapur, India
Sri Krishnadevaraya University, Anantapur, India
Sri Krishnadevaraya University, Anantapur, India
Jawaharlal Nehru Technological University, Hyderabad, India
Sri Krishnadevaraya University, Anantapur, India
Sri Krishnadevaraya University, Anantapur, India
- 1 Sri Krishnadevaraya University, Anantapur, India
- 2 Sri Krishnadevaraya University, Anantapur, India
- 3 Sri Krishnadevaraya University, Anantapur, India
- 4 Jawaharlal Nehru Technological University, Hyderabad, India
- 5 Sri Krishnadevaraya University, Anantapur, India
- 6 Sri Krishnadevaraya University, Anantapur, India
American Journal of Analytical Chemistry·Volume 08 (2017)·Pages 189–209·Published 1 March 2017·DOI10.4236/ajac.2017.83016
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Abstract
The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer concentrations were optimized adopting the statistical tool, design of experiments (DoE). The optimized formulation of present study exhibited desired controlled drug release characteristics in the alkaline pH conditions and at acidic environment the drug dissolution was minimal as intended.
KeywordsAtorvastatin Calcium TabletsControlled ReleaseCarbomerRelease Controlling PolymerGelling AgentPovidone
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