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American Journal of Analytical Chemistry is a peer reviewed international journal dedicated to the latest advancement in analytical chemistry. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts sub…
Sai Krishna Bompelliwar, Kishore Raju Vatsavai, Jayaram Kamma, Anil Kumar Ramgiri, Ravi Teja Meduri, Kishore Kumar Hotha
The cleaning validation is the most important step. Cleaning validation is a crucial aspect of pharmaceutical manufacturing to ensure that residues from previous batches do not contaminate subsequent products. This review explores the principles, regulatory r…
Kishore Raju Vatsavai, Jayaram Kamma, Anil Kumar Ramgiri, Kishore Kumar Hotha
Artificial Intelligence (AI) is transforming the pharmaceutical industry, from early drug discovery to post-market surveillance. The recent Food and Drug Administration (FDA) draft guidance “Artificial Intelligence in Drug and Biological Product Development”—…
Aline Zawadi Mahano, Christelle Waffo, Adriel Epanda Martin, Salama Matumaini Béatrice, Ombeni Mahano Aladdin, Roland Marini, 1 1
According to 2021 estimates, 247 million people suffered from malaria and 619,000 died from it worldwide. The World Health Organization (WHO) receives reports of substandard or falsified products, of which antimalarials and antibiotics are the most cited. The…
Yeboué Koffi Apollinaire, Konan Kouassi Pierre Alain, Diomandé Gbe Gondo Didier, Kouassi Charles Kouakou, Mamyrbékova-Békro Janat Akhanovna, Békro Yves-Alain
This study used quantitative 1 H NMR to characterize the chemical composition of eight honey samples from three distinct regions of Côte d’Ivoire. The analysis was carried out according to a standardized protocol in a certified laboratory. This analysis made…
Peng Huang, Guosheng Su, Jieling Lu, Tiaoping Tao, Liwen Huang, Liju Liao, Ruijian Lu, Yan Liao, Liefu Long
Objective: To develop a high-throughput method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous determination of serum concentrations of five commonly used antipsychotics (haloperidol, amisulpride, olanzapine, clozapine,…
Hua Zhao, Jiangwei Li, Frank Wu
Boc-protected amino acids, such as Boc-L-valine, are widely used as key starting materials in the synthesis of pharmaceutical drug substances, necessitating efficient and reliable analytical control strategies. In this work, a streamlined reversed-phase chira…
Shigenori Ogihara
This study conducted organic geochemical analyses of oil inclusions in quartz samples collected from Afghanistan and Pakistan. Samples from both countries contained large amounts of n -alkanes; however, sterane, triterpane, and isoprenoid hydrocarbons were no…
Adjoa Marcelle Yao, Djedjro Franck Meless, Sawa Andre Kpaibe, Linda Hé, Eyou Florent Missa, Awa Nakognon Tuo, Jean Simon Yao, Nina Ablé, N’cho Christophe Amin, 1 1
Ibuprofen, a derivative of propionic acid, is an anti-inflammatory and analgesic frequently used in the treatment of pain. However, ibuprofen is not immune to counterfeiting. The main objective of this work was to validate a stability-indicating HPLC method f…
Hanif Shaikh, Akash Gursal, Prashant Patil, Dilip Birati, Pradip Tarde, Sanjay A. Jadhav, Parag Chavan
Nitrosamine Drug Substance Related Impurities (NDSRIs) are commonly examined using High Performance Liquid Chromatography (HPLC) in combination with Mass Spectrometry (MS) detection. Due to the great sensitivity needed, high-resolution MS or MS/MS is commonly…
Praveen Rao Balguri, Harish Kumar Cherivirala
A stability-indicating reverse-phase high-performance liquid chromatographic (RP-HPLC) method was developed and validated for the simultaneous quantitative determination of degradation products of Buprenorphine and Naloxone in a combination pharmaceutical dos…
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American Journal of Analytical Chemistry is a peer reviewed international journal dedicated to the latest advancement in analytical chemistry. The goal of this journal is to keep a record of the state-of-the-art research and to promote study, research and improvement within its various specialties. All manuscripts sub… All articles are open access under a CC BY 4.0 licence, with authors retaining copyright.
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