Self-Assembly of Amyloid-Beta and Its Piezoelectric Properties — Oak Academic Publishing
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Self-Assembly of Amyloid-Beta and Its Piezoelectric Properties
Departamento de Física y Química Teórica, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior S/N, Coyoacán, Mexico City, Mexico
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Laboratorio de Evolución Química, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Mexico City, Mexico
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Laboratorio de Evolución Química, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Mexico City, Mexico
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Laboratorio de Evolución Química, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Mexico City, Mexico
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Nanoengineering Research group, Centre for Mechanical Technology & Automation, University of Aveiro, Aveiro, Portugal
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School of Physics and Conway Institute of Biomolecular and Biomedical Research University College Dublin Belfield, Dublin, Ireland
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Laboratorio de Evolución Química, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Mexico City, Mexico
1 Departamento de Física y Química Teórica, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior S/N, Coyoacán, Mexico City, Mexico
2 Laboratorio de Evolución Química, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Mexico City, Mexico
3 Laboratorio de Evolución Química, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Mexico City, Mexico
4 Laboratorio de Evolución Química, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Mexico City, Mexico
5 Nanoengineering Research group, Centre for Mechanical Technology & Automation, University of Aveiro, Aveiro, Portugal
6 School of Physics and Conway Institute of Biomolecular and Biomedical Research University College Dublin Belfield, Dublin, Ireland
7 Laboratorio de Evolución Química, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Mexico City, Mexico
Investigating amyloid nanofibril self-assembly, with an emphasis on the electromechanical property of amyloid peptides, namely, piezoelectricity, may have several important implications: 1) the self-assembly process can hinder the biological stability and give rise to the formation of amyloid structures associated with neurodegenerative diseases; 2) investigations in this field may lead to an improved understanding of high-performance, functional biological nanomaterials, 3) new technologies could be established based on peptide self-assembly and the resultant functional properties, e.g., in the creation of a piezoelectric device formed with vertical diphenylalanine peptide tubes as a piezoelectric biosensor, and 4) new knowledge can be generated about neurodegenerative disorders, potentially yielding new therapies. Therefore, in this review, we will present the current investigations associated with self-assembly of amyloid-beta, the mechanisms that generate new structures, as well as theoretical calculations exploring the functionality of the structures under physiological pressure and electric field.
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