Research ArticleOpen AccessGoogle Scholar indexed
Joint Effects of Mexidol and Nitroglycerine on Nitric Oxide Formation in Animal Liver Tissues
Department of Natural Sciences, Osh State University, Osh, Kyrgyzstan
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia
Department of Natural Sciences, Osh State University, Osh, Kyrgyzstan
Department of Medicine, Kyrgyz-Turkish University Manas, Bishkek, Kyrgyzstan
Department of Hospital Therapy, Zhalal-Abad State University, Zhalal-Abad, Kyrgyzstan
International Hope School Bangladesh of Gulshan Branch, Dhaka, Bangladesh
Science and Research Department, Osh State University, Osh, Kyrgyzstan
- 1 Department of Natural Sciences, Osh State University, Osh, Kyrgyzstan
- 2 Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia
- 3 Department of Natural Sciences, Osh State University, Osh, Kyrgyzstan
- 4 Department of Medicine, Kyrgyz-Turkish University Manas, Bishkek, Kyrgyzstan
- 5 Department of Hospital Therapy, Zhalal-Abad State University, Zhalal-Abad, Kyrgyzstan
- 6 International Hope School Bangladesh of Gulshan Branch, Dhaka, Bangladesh
- 7 Science and Research Department, Osh State University, Osh, Kyrgyzstan
American Journal of Molecular Biology·Volume 11 (2021)·Pages 73–82·Published 18 June 2021·DOI10.4236/ajmb.2021.113007
Copy link · social · email
Abstract
This work is investigating Mexidol (2-ethyl-6-methyl-3-hydroxy pyridine succinate) effect on the formation of nitric oxide (NO) in animal liver tissues, which is a regulator of many physiological processes and plays an important role in the vascular relaxation, neurotransmission and immune system functioning. Analyses performed by EPR spectroscopy revealed Hem-NO complex signals from paramagnetic centers in arbitrary units; produced nitrogen oxide amount in liver tissues was determined by method of double integration signals from nitrosyl complexes.
KeywordsNitroglycerineLiver TissueNitric OxideMexidolJoint EffectEPR Spectra
- Deviatkina, T.A., Lutsenko, R.V. and Vazhnichaia, E.M. (2003) Pharmacological Activity of Mexidol in the Stress-Induced Liver Damage. Eksperimental’naia i klinicheskaia farmakologiia, 66, 56-58.
- Katikova, O. (2002) Effect of Mexidol on the Homeostasis and Lipid Peroxidation in Paracetamol Poisoning. Eksperimental’naia i klinicheskaia farmakologiia, 65, 53-56.
- Agvald, P., Adding, L.C., Artlich, A., Persson, M.G. and Gustafsson, L.E. (2002) Mechanisms of Nitric Oxide Generation from Nitroglycerin and Endogenous Sources during Hypoxia in Vivo. British Journal of Pharmacology, 135, 373-382. https://doi.org/10.1038/sj.bjp.0704489
- Furchgott, R. and Zawadzki, J. (1980) The Obligatory Role of Endothelial Cells in the Relaxation of Arterial Smooth Muscle by Acetylcholine. Nature, 288, 373-376. https://doi.org/10.1038/288373a0
- Ignarro, L.J., Buga, G.M., Wood, K.S., Byrns, R.E. and Chaudhuri, G. (1987) Endothelium-Derived Relaxing Factor Produced and Released from Artery and Vein Is Nitric Oxide. Proceedings of the National Academy of Sciences of the United States of America, 84, 9265-9269. https://doi.org/10.1073/pnas.84.24.9265
- Ignarro, L.J. (1990) Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide. Annual Review of Pharmacology and Toxicology, 30, 535-560. https://doi.org/10.1146/annurev.pa.30.040190.002535
- Ignarro, L.J. (1990) Nitric Oxide. A Novel Signal Transduction Mechanism for Transcellular Communication. Hypertension, 16, 477-483. https://doi.org/10.1161/01.HYP.16.5.477
- Davies, S.A., Stewart, E.J., Huesmann, G.R., Skaer, N.J., Maddrell, S.H., Tublitz, N.J. and Dow, J.A. (1997) Neuropeptide Stimulation of the Nitric Oxide Signaling Pathway in Drosophila melanogaster Malpighian Tubules. The American Journal of Physiology, 273, R823-R827. https://doi.org/10.1152/ajpregu.1997.273.2.R823
- Nathan, C.F. (1983) Mechanisms of Macrophage Antimicrobial Activity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 77, 620-630. https://doi.org/10.1016/0035-9203(83)90190-6
- Palmieri, E.M., McGinity, C., Wink, D.A. and McVicar, D.W. (2020) Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight. Metabolites, 10, 429. https://doi.org/10.3390/metabo10110429
- Xue, Q., Yan, Y., Zhang, R. and Xiong, H. (2018) Regulation of iNOS on Immune Cells and Its Role in Diseases. International Journal of Molecular Sciences, 19, 3805. https://doi.org/10.3390/ijms19123805