<i>Terminalia </i><i>mantaly</i> H. Perrier is a plant used in traditional medicine for the treatment of various pathologies. However, <i>Terminalia </i><i>mantaly</i> H. Perrier could present potential health effects on patients. In order to determine the possible cardiotoxic effects of the hydro-alcoholic extract of the bark of <i>Te</i><i>r</i><i>minalia </i><i>mantaly</i> H. Perrier, (HAEBTM) forty (40) rats distributed randomly into 4 groups, including 10 animals per group (5 males and 5 females) were used. Animals in group 1 received distilled water and were used as a control group. On the other hand, groups 2, 3, 4 received oral administration a volume of the hydroalcoholic extract of <i>Terminalia </i><i>mantaly</i> H. Perrier corresponding to 1 mL/100g of body weight at 150 mg/kg, 300 mg/kg, 600 mg/kg, respectively. The extract was administered daily at the same time for 28 days and serum was collected once a week to evaluate cardiac biochemical markers using spectrophotometric methods using a Cobas C311<sup>®</sup> HITACHI biochemistry system. After one month of study, all rats were euthanized by overdose of ether, and the hearts of the rats were removed for gross morphological and histopathological analysis. Results were analysed using variance analysis (ANOVA) to compare outcomes as a function of doses administered and treatment times. The biochemical parameters ALT, LDH, CPK, CPKMB showed no significant change (p < 0.05) in the group of treated rats compared to the controls. However, the activities of ALAT, LDH experienced variations over time and an increase in CPK and CPKMB were observed. Microscopic observations of heart tissue sections from rats treated with the hydroalcoholic extract of <i>Terminalia </i><i>mantaly</i> showed no lesions, edema and necrosis. These results suggest that the hydroalcoholic extract of <i>Terminalia </i><i>mantaly</i> did not interfere with the functioning or alter the integrity of the heart.
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