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Genotypic Distribution of the Human Papillomavirus among Women with Cervical Cytological Abnormalities at the Sourô SANOU University Hospital in Bobo-Dioulasso, Burkina Faso

¹ Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso
² Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso
³ Centre Hospitalier Universitaire Sourô SANOU, Bobo Dioulasso, Burkina Faso
⁴ Centre Hospitalier Universitaire Sourô SANOU, Bobo Dioulasso, Burkina Faso
⁵ Centre Hospitalier Universitaire Sourô SANOU, Bobo Dioulasso, Burkina Faso
⁶ Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso
⁷ Centre National de la Recherche Scientifique et Technologique, Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, Burkina Faso
⁸ Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso
⁹ Pietro Annigoni Biomolecular Research Centre (CERBA), Ouagadougou, Burkina Faso
¹⁰ Pietro Annigoni Biomolecular Research Centre (CERBA), Ouagadougou, Burkina Faso
¹¹ Pietro Annigoni Biomolecular Research Centre (CERBA), Ouagadougou, Burkina Faso
¹² Pietro Annigoni Biomolecular Research Centre (CERBA), Ouagadougou, Burkina Faso
¹³ Centre National de la Recherche Scientifique et Technologique, Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, Burkina Faso
¹⁴ Pietro Annigoni Biomolecular Research Centre (CERBA), Ouagadougou, Burkina Faso
¹⁵ Centre National de la Recherche Scientifique et Technologique, Institut de Recherche en Sciences de la Santé (IRSS), Ouagadougou, Burkina Faso
¹⁶ Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE), Université Joseph KI-ZERBO, Ouagadougou, Burkina Faso

American Journal of Molecular Biology·Volume 15 (2024)·Pages 11–24·Published 26 November 2024·DOI10.4236/ajmb.2025.151002

Abstract

Cervical cancer is the fourth most common cancer worldwide, accounting for 6.8% of new cancer cases and 8.1% of cancer-related deaths. About 85% of these deaths occurred in low- and middle-income countries. The aim of this study was to assess the frequency and distribution of the human papillomavirus (HPV) genotypes in women showing cytological abnormalities of the cervix at the Sourô SANOU University Hospital (CHUSS) in Bobo-Dioulasso, Burkina Faso. This is a descriptive study of women recruited at the CHUSS. The cervico-uterine smear examination was carried out at the CHUSS Anatomy and Pathology Department for cervical cancer screening. The data were collected from women with atypical cells on their cervico-uterine smear. Cervicovaginal samples were taken from consenting women and HPV genotyping was performed using the HPV Direct FLOW CHIP kit at CERBA. We obtained approval from the ethics committee. The data were analyzed using the SPSS 26 software. The results of the study showed that 67.79% of the participants were aged between 50 and 65, a group that is particularly vulnerable to persistent infection with high-risk oncogenic HPV genotypes. Of the women screened, 40.7% were HPV positive and 29.2% had multiple infections. The most common genotypes were HPV 35, followed by HPV 18, 52, 58 and 66. These data highlight the need for increased surveillance and targeted prevention strategies among this female population.

KeywordsGenotypingHuman PapillomavirusCervical Cytological AbnormalitiesBurkina Faso

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Genotypic Distribution of the Human Papillomavirus among Women with Cervical Cytological Abnormalities at the Sourô SANOU University Hospital in Bobo-Dioulasso, Burkina Faso

Abstract

References (30)