Research ArticleOpen AccessGoogle Scholar indexed
Alterations in Goat Microbiota Following Panax n otoginseng Supplementation: Metagenomic Insights and Potential for Gastrointestinal Nematode Control
Sherman Lewis School of Agriculture and Applied Sciences, Langston University, Langston, Oklahoma, USA
Sherman Lewis School of Agriculture and Applied Sciences, Langston University, Langston, Oklahoma, USA
Sherman Lewis School of Agriculture and Applied Sciences, Langston University, Langston, Oklahoma, USA
- 1 Sherman Lewis School of Agriculture and Applied Sciences, Langston University, Langston, Oklahoma, USA
- 2 Sherman Lewis School of Agriculture and Applied Sciences, Langston University, Langston, Oklahoma, USA
- 3 Sherman Lewis School of Agriculture and Applied Sciences, Langston University, Langston, Oklahoma, USA
American Journal of Molecular Biology·Volume 15 (2025)·Pages 277–282·Published 22 September 2025·DOI10.4236/ajmb.2025.154019
Copy link · social · email
Abstract
Certain medicinal plants are known to have potent effects on egg hatching and larval motility of gastrointestinal nematodes (GIN) such as Haemonchus contortus (barber pole worm). In this study, we investigated the impact of Panax notoginseng ( P. notoginseng ) extracts on the gut microbiome of goats, in comparison to Syzygium aromaticum and Piper nigrum when used as treatments towards Haemonchus contortus ( H. contortus ). Using metagenomic analysis of rumen fluid and fecal samples, we observed significant alterations in the microbial community structure, specifically in the P. notoginseng treatment group. Notably, several microbial taxa were significantly upregulated in treated animals. These findings provide a foundation for further research to identify and harness microbiome-mediated resistance to gastrointestinal nematode (GIN) parasitism in goats.
KeywordsMedicinal PlantsGoatsMetagenomicsPanax notoginsengMicrobiomeGastrointestinal Nematodes
- Besier, R.B., Kahn, L.P., Sargison, N.D. and Van Wyk, J.A. (2016) The Pathophysiology, Ecology and Epidemiology of Haemonchus contortus Infection in Small Ruminants. Advances in Parasitology , 91, 95-143. https://doi.org/10.1016/bs.apar.2016.02.022
- Mamun, M.A.A., Sandeman, M., Rayment, P., Brook-Carter, P., Scholes, E., Kasinadhuni, N., et al. (2020) Variation in Gut Bacterial Composition Is Associated with Haemonchus contortus Parasite Infection of Sheep. Animal Microbiome , 2, Article No. 3. https://doi.org/10.1186/s42523-020-0021-3
- Chiejina, S.N. and Behnke, J.M. (2011) The Unique Resistance and Resilience of the Nigerian West African Dwarf Goat to Gastrointestinal Nematode Infections. Paras ites & Vectors , 4, Article No. 12. https://doi.org/10.1186/1756-3305-4-12
- Castillo-Mitre, G.F., Olmedo-Juárez, A., Rojo-Rubio, R., González-Cortázar, M., Mendoza-de Gives, P., Hernández-Beteta, E.E., et al. (2017) Caffeoyl and Coumaroyl Derivatives from Acacia cochliacantha Exhibit Ovicidal Activity against Haemo nchus contortus . Journal of Ethnopharmacology , 204, 125-131. https://doi.org/10.1016/j.jep.2017.04.010
- Leon-Castro, Y., Olivares, J. and Rojas-Hernandez, S. (2015) Chemical Composition of Three Trees Fodders and Effects in Control of Haemonchus contortus and Change of Body Weight in Kids. Agroforestry Natural Ecosystem , 2, 193-201.
- Papadopoulos, E. (2008) Anthelmintic Resistance in Sheep Nematodes. Small Ruminant Research , 76, 99-103. https://doi.org/10.1016/j.smallrumres.2007.12.012
- Tilahun, Y., Pinango, J.Q., Johnson, F., Lett, C., Smith, K., Gipson, T., et al. (2022) Transcript and Blood-Microbiome Analysis towards a Blood Diagnostic Tool for Goats Affected by Haemonchus contortus . Scientific Reports , 12, Article No. 5362. https://doi.org/10.1038/s41598-022-08939-x
- Stafford, K.J., West, D.M. and Pomroy, W.E. (1994) Nematode Worm Egg Output by Ewes. New Zealand Veterinary Journal , 42, 30-32. https://doi.org/10.1080/00480169.1994.35778
- Botura, M.B., Silva, G.D., Lima, H.G., Oliveira, J.V.A., Souza, T.S., Santos, J.D.G., et al. (2011) In Vivo Anthelmintic Activity of an Aqueous Extract from Sisal Waste ( Aga ve sisalana Perr.) against Gastrointestinal Nematodes in Goats. Veterinary Parasitology , 177, 104-110. https://doi.org/10.1016/j.vetpar.2010.11.039
- Sunandhadevi, S., Rao, M.L.Y., Dixit, P., Dixit, A.K., Shukla, P.C. and Baghel, R. (2017) In Vivo Anthelmintic Activity of a Herbal Formulation against Naturally Acquired Gastrointestinal Nematode in Goats. Environmental and Ecology Journal , 35, 933-935.