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Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease
Department of Medicine, University of Chicago, Chicago, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, USA
Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
Department of Medicine, University of Chicago, Chicago, USA
- 1 Department of Medicine, University of Chicago, Chicago, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, USA
- 2 Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
- 3 Department of Medicine, University of Chicago, Chicago, USA
American Journal of Molecular Biology·Volume 02 (2012)·Pages 110–112·Published 28 April 2012·DOI10.4236/ajmb.2012.22012
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Abstract
Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phospholipase A 2 for which cleavage specificity has been established when these modified lipids are in a free form.
KeywordsPlasminogenApolipoprotein(a)Lipoprotein(a)Oxidized PhospholipidsOxidized Phosphatidylcholines
- McLean, J.W., Tomlinson, J.E., Kuang, W., Eaton, D.L., Chen, E.Y., Fless, G.M., Scanu, A.M. and Lawn, R.M. (1987) cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature, 330, 132-137. doi:10.1038/330132a0
- Scanu, A.M. and Fless, G.M. (1990) Lipoprotein(a): Heterogeneity and biological relevance. Journal of Clinical Investigation, 85, 1709-1715. doi:10.1172/JCI114625
- Hobbs, H.H. and White, A.L. (1999) Lipoprotein(a): Intrigues and insights. Current Opinion in Lipidology, 10, 225-236. doi:10.1097/00041433-199906000-00005
- Scanu, A.M. (1992) Lipoprotein(a)—Its inheritance and molecular basis of its atherothrombotic role. Molecular and Cellular Biochemistry, 113, 127-131. doi:10.1007/BF00231532
- Scanu, A.M. (2003) Lipoprotein(a) and the atherothrombotic process: Mechanistic insights and clinical implications. Current Atherosclerosis Reports, 5, 106-113. doi:10.1007/s11883-003-0081-3
- Tsimikas, S. and Witztum, J.L. (2008) The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity. Current Opinion in Lipidology, 19, 369-377. doi:10.1097/MOL.0b013e328308b622
- Philips, B. and Scanu, A.M. (2008) Viewing the cardiovascular pathogenicity of Lp(a) from the pro-inflammatory side. Vascular Disease Prevention, 5, 150-155.
- Berliner, J.A., Leitinger, N. and Tsimikas, S. (2009) The role of oxidized phospholipids in atherosclerosis. Journal of Lipid Research, 50, S207-S212. doi:10.1194/jlr.R800074-JLR200
- Edelstein, C., Pfaffinger, D., Hinman, J., Miller, E., Lipkind, G., Tsimikas, S., Bergmark, C., Getz, G.S., Witztum, J.L. and Scanu, A.M. (2003) Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a). Journal of Biological Chemistry, 26, 52841-528447. doi:10.1074/jbc.M310425200
- Plow, E.F. and Hoover-Plow, J. (2004) The functions of plasminogen in cardiovascular disease. Trends in Cardiovascular Medicine, 14, 180-186. doi:10.1016/j.tcm.2004.04.001
- Edelstein, C., Pfaffinger, D., Yang, M., Hill, J.S. and Scanu, A.M. (2010) Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts. Biochimica et Biophysica Acta, 1801, 738-745.
- Edelstein, C., Pfaffinger, D., Reichert, E.C., Stafforini, D.M. and Scanu, A.M. (2010) Mouse plasminogen has oxidized phosphatidylcholine adducts that are not metabolized by lipoprotein-associated phospholipase A2 under basal conditions. International Journal of Molecular Science, 11, 5339-5347.