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The Transcription Factors GATA-1 and GATA-4 Have Opposite Effects on DNA Expression Driven by an Amh Promoter
3IR, The Ashworth Laboratory, The University of Edinburgh, Edinburgh, UK
- 1 3IR, The Ashworth Laboratory, The University of Edinburgh, Edinburgh, UK
American Journal of Molecular Biology·Volume 04 (2014)·Pages 150–158·Published 16 July 2014·DOI10.4236/ajmb.2014.43016
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Abstract
An Amh promoter driving expression of a reporter gene (d2EGFP) has been used to analyze the role of two specific promoter transcription factor binding elements. In addition a downstream (3’) enhancer (DE) was also investigated. The transcription factors GATA-1 and GATA-4 had opposite effects, the former being incremental and the latter decremental. The quantitative balance between these two factors may provide a degree of control over the level of gene expression.
KeywordsSMAT-1Mouse Pre-Pubertal Sertoli<i>In Vitro</i>Amh Promoterd2EGFPTranscription FactorsGATA-1GATA-4
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