Therapeutic Effects of Essential Oil from Waste Leaves of <i>Psidium guajava</i> L. against Cosmetic Embarrassment Using Phylogenetic Approach — Oak Academic Publishing
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Therapeutic Effects of Essential Oil from Waste Leaves of <i>Psidium guajava</i> L. against Cosmetic Embarrassment Using Phylogenetic Approach
Biological Product Laboratory, Department of Botany, University of Allahabad, Allahabad, India
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Biological Product Laboratory, Department of Botany, University of Allahabad, Allahabad, India
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Department of Horticulture, Aromatic & Medicinal Plants, Mizoram University, Aizawl, India
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Biological Product Laboratory, Department of Botany, University of Allahabad, Allahabad, India
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Department of Dermatology and Veneral Diseases, M.L.N.Medical College, Allahabad, India.
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Biological Product Laboratory, Department of Botany, University of Allahabad, Allahabad, India
1 Biological Product Laboratory, Department of Botany, University of Allahabad, Allahabad, India
2 Biological Product Laboratory, Department of Botany, University of Allahabad, Allahabad, India
3 Department of Horticulture, Aromatic & Medicinal Plants, Mizoram University, Aizawl, India
4 Biological Product Laboratory, Department of Botany, University of Allahabad, Allahabad, India
5 Department of Dermatology and Veneral Diseases, M.L.N.Medical College, Allahabad, India.
6 Biological Product Laboratory, Department of Botany, University of Allahabad, Allahabad, India
Medicinal plants are facing threats due to loss of habitat and overexploitation of knows species. Therefore the present work shows utilization of essential oil from discarded leaves of Psidium guajava Linn. against human dermatophytic fungi Trichophyton rubrum, T. mentagrophytes, Trichophyton violaceum, Trichophyton tonsurans, Epidermophyton floccosum, Microsporum gypseum and Microsporum canis. The oil was found to be fungicidal at 3.0 μl/ml and it tolerated heavy inoculum of pathogens at fungicidal concentrations. The fungicidal activity of the oil was thermostable, up to 70°C and shelf life was found to be six months, which was maximum the time taken into consideration. The oil having cineole, caryophyllane, copaene, azulene and eucalyptol as main constituents, exhibited broad fungicidal activity. The oil did not show any adverse effect on mammalian skin upto 5% concentration. Phylogeny of the dermatophytes with respect to toxicity of the oil has also been discussed using molecular data. The cost effective formulation from waste leaves can be exploited after undergoing double blind successful multicentral topical testing.
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