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Effect of Cigarette Smoke on Diabetic Skin and Protection with Topical Administration of Pinus halepensis Extract
Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
- 1 Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
- 2 Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
- 3 Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
- 4 Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
- 5 Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
- 6 Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
- 7 Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
- 8 Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
- 9 Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
- 10 Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
- 11 Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
American Journal of Plant Sciences·Volume 05 (2014)·Pages 3964–3973·Published 18 December 2014·DOI10.4236/ajps.2014.526415
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Abstract
Compared to normal, diabetic skin is characterized by great sensitivity. Oxidative stress is directly involved, contributing to accelerated skin aging, xerodermia and poor wound healing. In the last 10 years, cigarette smoke (CS) exposure has been associated with several skin and dermatological conditions and is directly related to the oxidative stress affecting the skin. However, limited data exist concerning the effect of CS on diabetic skin. Some of the effects of cigarette smoke exposure on the skin of hairless diabetic mice were hereby studied and the potential skin protection by topical applications of Pinus halepensis bark extract was investigated. Female hairless SKH-2 diabetic mice were exposed for 8 days to tobacco smoke and topical applications were performed twice daily. Biophysical parameters such as transepidermal water loss (TEWL), skin elasticity and erythema were measured. In addition, the oxidative stress was evaluated. The results show that diabetes and CS have a synergistic negative action on skin condition, with the development of xerosis and high ROS levels whilst topical applications of Pinus halepensis bark extract protect efficiently the toxic effect of CS on skin, by decreasing skin dryness, oxidative stress and blood glucose levels.
KeywordsCigarette SmokeSkinDiabetesMicePinus halepensis Bark Extract
- Cancer Research UK (2014) Healthy Living: Smoking and Cancer. http://www.cancerresearchuk.org/cancer-info/healthyliving/smoking-and-cancer/smoking-and-cancer
- Salahundin, S., Prabhakaran, D. and Roy, A. (2012) Pathophysiological Mechanisms of Tobacco-Related CVD. Glob Heart, 7, 113-120. http://dx.doi.org/10.1016/j.gheart.2012.05.003
- Ambrose, J.A. and Barua, R.S. (2004) The Pathophysiology of Cigarette Smoking and Cardiovascular Disease: An Update. Journal of the American College of Cardiology, 43, 1731-1737. http://dx.doi.org/10.1016/j.jacc.2003.12.047
- Bernhard, D., Moser, C., Backovic, A. and Wick, G. (2007) Cigarette Smoke—An Aging Accelerator. Experimental Gerontology, 42, 160-165. http://dx.doi.org/10.1016/j.exger.2006.09.016
- Khanna, A., Guo, M., Mehra, M. and Royal, W. (2013) Inflammation and Oxidative Stress Induced by Cigarette Smoke in Lewis Rat Brains. Journal of Neuroimmunology, 254, 69-75. http://dx.doi.org/10.1016/j.jneuroim.2012.09.006
- Zavitz, C., Gaschler, G., Robbins, C., Botehlo, F., Cox, G. and Stampfli, M. (2008) Impact of Cigarette Smoke on T and Bcell Responsiveness. Cellular Immunology, 253, 38-44. http://dx.doi.org/10.1016/j.cellimm.2008.04.012
- Radin, R., Hatch, E., Rothman, K., Mikkelsen, E., Soresen, H.T., Riis, A. and Wise, L. (2014) Active and Passive Smoking and Fecundability in Danish Pregnancy Planners. Fertility and Sterility, 102, 183-191. http://dx.doi.org/10.1016/j.fertnstert.2014.03.018
- Taymour, M. (2010) Cigarette Smoking and Male Infertility. Journal of Advanced Research, 1, 179-186. http://dx.doi.org/10.1016/j.jare.2010.05.002
- Stratton, K., Shetty, P., Wallace, R. and Bondurant, S. (2001) Clearing the Smoke: Assessing the Science Base for Tobacco Harm Reduction. National Academies Press (US), Washington DC, 560-580.
- Sticozzi, C., Belmonte, G., Pecorelli, A., Arezzini, B., Gardi, C., Maioli, E., et al. (2012) Cigarette Smoke Affects Keratinocyte SRB1 Expression and Localization via H2O2 Production and HNE Protein Adducts Formation. PLOS One, 7, e33592. http://dx.doi.org/10.1371/journal.pone.0033592
- Pavlou, P., Rallis, M., Deliconstantinos, G., Papaioannou, G. and Grando, S.A. (2009) In Vivo Data on the Influence of Tobacco Smoke an UV Light on Murine Skin. Toxicology and Industrial Health, 25, 231-239. http://dx.doi.org/10.1177/0748233709103209
- Morita, A. (2007) Tobacco Smoke Causes Premature Skin Aging. Journal of Dermatological Science, 48, 169-175. http://dx.doi.org/10.1016/j.jdermsci.2007.06.015