Hepatoprotective Activity of Plant Peptides

Abstract

Peptides (molecular weights are 1200 – 11,600 Da) biologically acting at concentration 10 -8 - 10 -15 mg/ml were obtained from leaves of dill Anethum graveolens L. and celandine Chelidonium majus L. by circular dichroism (CD) spectroscopy. We have shown that these peptides form second structure characterized by the prevalence of β-structures and coil in water solution. In model of organotypic roller culturing of triton liver in vitro, the ability of the peptides isolated from Anethum graveolens L. and Chelidonium majus L. at concentration 10 -8 - 10 -15 mg/ml to influence increasing of pigment cells, which provided protective function of organism, was demonstrated.