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Anti-Cancer Effects and Mechanisms of Capsaicin in Chili Peppers

¹ School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
² School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
³ School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
⁴ School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
⁵ School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
⁶ Hospital of Integrated Chinese and Western Medicine, Southern Medical University, Guangzhou, China
⁷ School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China

American Journal of Plant Sciences·Volume 06 (2015)·Pages 3075–3081·Published 2 December 2015·DOI10.4236/ajps.2015.619300

Abstract

Cancer is a major cause of morbidity and mortality all over the world and a promising area of cancer research is concentrated on chemoprevention by nutritional compounds. Capsaicin, traditionally used as a food additive and an analgesic, is one of the main pungent ingredients in chili peppers. Recent studies have shown that capsaicin has anti-cancer effects in various types of cancer model. The purpose of this review is to outline the anticarcinogenic effect of capsaicin and its mechanism.

KeywordsChili PeppersCapsaicinAnticarcinogenMechanism

WHO (2014) Global Cancer Rates Could Increase by 50% to 15 Million by 2020. http://www.who.int/mediacentre/news/releases/2003/pr27/en
Park, S.Y., Kim, J.Y., Lee, S.M., Jun, C.H., Cho, S.B., Park, C.H., Joo, Y.E., Kim, H.S., Choi, S.K. and Rew, J.S. (2014) Capsaicin Induces Apoptosis and Modulates MAPK Signaling in Human Gastric Cancer Cells. Molecular Medicine Reports, 9, 499-502.
Ito, K., Nakazato, T., Yamato, K., Miyakawa, Y., Yamada, T., Hozumi, N., Segawa, K., Ikeda, Y. and Kizaki, M. (2004) Induction of Apoptosis in Leukemic Cells by Homovanillic Acid Derivative, Capsaicin, through Oxidative Stress: Implication of Phosphorylation of p53 at Ser-15 Residue by Reactive Oxygen Species. Cancer Research, 64, 1071-1078. http://dx.doi.org/10.1158/0008-5472.CAN-03-1670
Huh, H.C., Lee, S.Y., Lee, S.K., Park, N.H. and Han, I.S. (2011) Capsaicin Induces Apoptosis of Cisplatin-Resistant Stomach Cancer Cells by Causing Degradation of Cisplatin-Inducible Aurora-A Protein. Nutrition and Cancer, 63, 1095-1103. http://dx.doi.org/10.1080/01635581.2011.607548
Ip, S.W., Lan, S.H., Lu, H.F., Huang, A.C., Yang, J.S., Lin, J.P., Huang, H.Y., Lien, J.C., Ho, C.C., Chiu, C.F., Wood, W. and Chung, J.G. (2012) Capsaicin Mediates Apoptosis in Human Nasopharyngeal Carcinoma NPC-TW 039 Cells through Mitochondrial Depolarization and Endoplasmic Reticulum Stress. Human & Experimental Toxicology, 31, 539-549. http://dx.doi.org/10.1177/0960327111417269
Mori, A., Lehmann, S., O’Kelly, J., Kumagai, T., Desmond, J.C., Pervan, M., McBride, W.H., Kizaki, M. and Koeffler, H.P. (2006) Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells. Cancer Research, 66, 3222-3229. http://dx.doi.org/10.1158/0008-5472.CAN-05-0087
Huang, S.P., Chen, J.C., Wu, C.C., Chen, C.T., Tang, N.Y., Ho, Y.T., Lo, C., Lin, J.P., Chung, J.G. and Lin, J.G. (2009) Capsaicin-Induced Apoptosis in Human Hepatoma HepG2 Cells. Anticancer Research, 29, 165-174.
Govindarajan, V.S. and Sathyanarayana, M.N. (1991) Capsicum-Production, Technology, Chemistry, and Quality. Part V. Impact on Physiology, Pharmacology, Nutrition, and Metabolism; Structure, Pungency, Pain, and Desensitization Sequences. Critical Reviews in Food Science and Nutrition, 29, 435-474. http://dx.doi.org/10.1080/10408399109527536
Reyes-Escogido, M.L., Gonzalez-Mondragon, E.G. and Vazquez-Tzompantzi, E. (2011) Chemical and Pharmacological Aspects of Capsaicin. Molecules, 16, 1253-1270. http://dx.doi.org/10.3390/molecules16021253

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Anti-Cancer Effects and Mechanisms of Capsaicin in Chili Peppers

Abstract

References (61)