Synergistic Effect of Watermelon Powder and <i>Lactococcus lactis</i> subsp <i>lactis</i> Supplemented Diet Partially Ameliorates A<i>β</i>42-Dependent Lifespan Shorten and Flight Impairment in Transgenic <i>Drosophila</i>

Abstract

Oxidative stress has been strongly related with Alzheimer disease pathogenesis. We determined the effects of watermelon powder (WMP) and Lactococcus lactis subsp lactis (LAL) supplementation on the generated A β 42-induced phenotypes in a Drosophila melanogaster model of AD. Enhanced A β 42 expression in D. melanogaster neurons can diminish lifespan and flight ability. We have observed longevity methods to assay the effects of WMP and LAL on D. melanogaster survival. Furthermore, flies expressing A β 42 in their body fed WMP and LAL had up to 90 days, or 35% longer median lifespan than those fed a control diet. In addition, synergistic effect of WMP and LAL improved A β 42-induced flight impairments in the Drosophila wing tissues. Our microscope experiments revealed that individuals fed synergistic effect of WMP and LAL had ameliorated A β 42 expression as well as increment of flight ability than A β 42-induced flies. We propose that WMP is typically rich in L-citrulline and LAL, rich in naturally occurring probiotics and antioxidants, and that it promotes the survival of neurons in brain and wing muscle tissues with increased levels of A β 42 via a protective cell survival mechanism.