Five wild plant species belonging to different families ( <i> Chenopodium album , Plantago major , Elytrigia elongata , Filipendula ulmaria </i> and <i> Nigella sativa </i> ) widely spread in Russian Federation and the former USSR were evaluated for their ability to inhibit growth of two important human food-borne pathogens ( <i> Escherichia coli </i> O157:H7 and <i> Listeria monocytogenes </i> strain EGD-e) and eight plant pathogens ( <i> Alternaria alternata , Alternaria tenuissima , Bipolaris sorokiniana , Stagonospora nodorum , Fusarium solani , Fusarium oxysporum , Fusarium culmorum </i> and <i> Phytophtora infestans </i> ). To isolate biologically active compounds from seeds, a step-wise procedure including extraction with hexane, ethyl acetate, ethanol, and 10% acetic acid followed by reversed-phase HPLC was developed. Using disc-diffusion assay, the highest activity against <i> E. coli </i> O157:H7 was observed with extracts from <i> F. ulmaria </i> (hexane and ethyl acetate extracts and the unbound RP-HPLC fraction) and <i> P. major </i> (ethyl acetate extract and the unbound RP-HPLC fraction); <i> E. elongate </i> (the unbound RP-HPLC fraction) was less active. The extracts from <i> P. major </i> and <i> E. elongate </i> (the unbound RP-HPLC fractions) were equally highly active against <i> L. monocytogenes </i> , while those of <i> F. ulmaria </i> (the unbound RP-HPLC fraction) and <i> N. sativa </i> (hexane and ethyl acetate extracts) were less active against this pathogen. The dynamics of <i> L. monocytogenes </i> EGD-е and <i> E. coli </i> O157:H7 growth in the presence of two most potent extracts (RP-HPLC-unbound fractions of <i> P. major </i> and <i> E. elongate </i> and the hexane extract of <i> F. ulmaria </i> ) was studied. Al
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