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Bioinformatics Analysis of the Interaction between Coat Protein and Nuclear Shuttle Protein in <i>Babuvirus</i>
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture and Rural Affairs, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Hainan Provincial Key Laboratory of Microbiology, Haikou, China
Hainan Provincial Key Laboratory of Microbiology, Haikou, China
Hainan Provincial Key Laboratory of Microbiology, Haikou, China
Hainan Provincial Key Laboratory of Microbiology, Haikou, China
Hainan Provincial Key Laboratory of Microbiology, Haikou, China
- 1 Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture and Rural Affairs, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
- 2 Hainan Provincial Key Laboratory of Microbiology, Haikou, China
- 3 Hainan Provincial Key Laboratory of Microbiology, Haikou, China
- 4 Hainan Provincial Key Laboratory of Microbiology, Haikou, China
- 5 Hainan Provincial Key Laboratory of Microbiology, Haikou, China
- 6 Hainan Provincial Key Laboratory of Microbiology, Haikou, China
American Journal of Plant Sciences·Volume 10 (2019)·Pages 622–630·Published 16 April 2019·DOI10.4236/ajps.2019.104045
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Abstract
Protein and protein interactions play important roles in many biological processes and are responsible for carrying out the function of biological regulatory network in living organisms. Previous study indicated that Banana bunchy top virus (BBTV) coat protein (CP) interacted with BBTV nuclear shuttle protein (NSP). However, the protein and protein interaction and the binding affinity of CP and NSP in Babuvirus are remaining unclear. In this study, the CPs and NSPs proteins of BBTV, Abaca bunchy top virus (ABTV) and Cardamom bushy dwarf virus (CBDV) were used for bioinformatic analysis. The binding free energy and the dissociation constant of the possible interaction proteins were tested in PPA-Pred2, and the results confirmed CP interaction with NSP in Babuvirus . The study will help us to understand the interaction between viral protein and viral protein, and the pathogenesis mechanism of Babuvirus in host plants.
Keywords<i>Babuvirus</i>CoatproteinNuclear Shuttle ProteinInteractionBioinformatics Analysis
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