Identification and Localization of Prostate Cancer with Combined Use of T2-Weighted, Diffusion Weighted MRI and Proton MR Spectroscopy, Correlation with Histopathology — Oak Academic Publishing
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Identification and Localization of Prostate Cancer with Combined Use of T2-Weighted, Diffusion Weighted MRI and Proton MR Spectroscopy, Correlation with Histopathology
Radiology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
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Radiology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
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Radiology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
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Radiology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
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Urology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
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Pathology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
1 Radiology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
2 Radiology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
3 Radiology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
4 Radiology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
5 Urology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
6 Pathology Department, D??kap? Y?ld?r?m Beyaz?t Education and Research Hospital, Ankara, Turkey
Purpose : To predict the diagnostic performance of combined use of T2- weighted imaging (T2W) - diffusion weighted MRI (DWI) and apparent diffusion coefficient (ADC)-proton MR spectroscopy (H-MRS) for the detection of prostate cancer, correlated to histopathology as the reference standard. Method : After institutional review board approval , 40 patients with prostate cancer were included in this retrospective research. Two readers evaluated the results of T2W, DWI-ADC mapping and H-MRS independently for the depiction of prostate cancer. Reference standard was the TRUS- guided biopsy and the surgical histopathological results. Statistical analysis was assessed by Fisher’s exact t-test, Wilcoxon signed rank test, variance analysis test with Kappa (k) values and receiver operating characteristics (ROC) curve for ADC values, Cho/Cit and Cho + Cre/Cit ratios for each observer. Results : Both readers declined 46% sensitivity and 68% specificity for T2W sequence, 29% sensitivity and 82% specificity for DWI-ADC mapping and 49% specificity for Cho/Cit and Cho + Cre/Cit ratios, 69% sensitivity for Cho/Cit 70% sensitivity for Cho + Cre/Cit ratios of H-MRS. T2W + DWI-ADC mapping + H-MRS ( Cho/Cit and Cho + Cre/Cit ratios) regarded 81% sensitivity and 66% specificity, with significant statistical differences to the reference histopathology (p < 0.05). Conclusion : Combination of T2W, DWI and H-MRS were more sensitive and more accurate than either sequences alone, for prostate cancer localization and detection.
KeywordsMRIProstate CancerDWIH-MRST2W
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