Fungi that attack field crops and contaminate agricultural commodities produce mycotoxins when conditions are favorable. These are specialized metabolites made of poisonous chemical compounds created by bacteria, fungi, or plants that aren’t involved in the organism’s usual growth, development, or reproduction. They have an adversarial hold on humans, wildlife, and the agricultural sector, resulting in mysterious ailments and economic disruptions. Mycotoxins-tainted food and fodder can be found all over the world, posing a global concern. Consumption of contaminated food and fodder is a typical cause of epidemic outbreaks. Other mycotoxins have been associated with esophageal cancer and neural tube defects (NTDs); the immunotoxin deoxynivalenol (DON) causes diarrhea when combined with trichothecenes, and ochratoxin A (OTA) has been linked to kidney failure. The direct market costs associated with missed trade or lower revenues owing to tainted food or feed could be viewed as the economic repercussions of mycotoxins on human society. This review describes frequent groups of mycotoxins in detail, their impact on global health, their impact on the socio-economy; the methods of detection and prevention of these mycotoxins.
KeywordsMycotoxinsGlobal Health ImpactSocio-Economy ImpactMycotoxin’s DetectionPrevention Methods
Ismaiel, A.A. and Papenbrock, J. (2015) Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity. Agriculture, 5, 493-537. https://doi.org/10.3390/agriculture5030492
Agriopoulou, S., Stamatelopoulou, E. and Varzakas, T. (2020) Advances in Occurrence, Importance, and Mycotoxin Control Strategies: Prevention and Detoxification in Foods. Foods, 9, Article No. 137. https://doi.org/10.3390/foods9020137
Smith, M.C., Madec, S., Coton, E. and Hymery, N. (2016) Natural Co-Occurrence of Mycotoxins in Foods and Feeds and Their in Vitro Combined Toxicological Effects. Toxins, 8, Article No. 94. https://doi.org/10.3390/toxins8040094
Richard, J.L. (2007) Some Major Mycotoxins and Their Mycotoxicoses—An Overview. International Journal of Food Microbiology, 119, 3-10. https://doi.org/10.1016/j.ijfoodmicro.2007.07.019
Selamat, J. and Iqbal, S.Z. (2016) Food Safety: Basic Concepts, Recent Issues, and Future Challenges. Springer, Berlin, 160 p.
Pleadin, J. (2015) Mycotoxins in Grains and Feed—Contamination and Toxic Effect in Animals. Biotechnology in Animal Husbandry, 31, 441-456. https://doi.org/10.2298/BAH1504441P
Krogh, P. (1978) Mycotoxicoses of Animals. Mycopathologia, 65, 43-45. https://doi.org/10.1007/BF00447172
Bryła, M., Waśkiewicz, A., Ksieniewicz-Woźniak, E., Szymczyk, K. and Edrzejczak, R.J. (2018) Modified Fusarium Mycotoxins in Cereals and Their Products—Metabolism, Occurrence, and Toxicity: An Updated Review. Molecules, 23, Article No. 963. https://doi.org/10.3390/molecules23040963
European Food Safety Authority (2004) Opinion of the Scientific Panel on Contaminants in the Food Chain [CONTAM] Related to Zearalenone as Undesirable Substance in Animal Feed. The EFSA Journal, 2, 1-35. https://doi.org/10.2903/j.efsa.2004.89
The European Commission (2013) Recommendations on the Presence of T-2 and HT-2 Toxin in Cereals and Cereal Products. Official Journal of the European Union, 56, 12-15.
Torelli, E., Firrao, G., Bianchi, G., Saccardo, F. and Locci, R. (2012) European Commission Regulation No. 1126/2007 Amending Regulation (EC) No 1881/2006 Setting Maximum Levels for Certain Contaminants in Foodstuffs as Regards Fusarium Toxins in Maize and Maize Products. Journal of the Science of Food and Agriculture, 92, 479-487.
Abdel-Wahh, M.A. and Kholif, A.M. (2010) Mycotoxins in Animal Feeds and Prevention Strategies: A Review. Asian Journal of Animal Sciences, 4, 113-131. https://doi.org/10.3923/ajas.2010.113.131
Telephone, E. (2020) Safety Data Sheet: Aflatoxin B1: 1. Identification of the Substance/Mixture and of the Company. 6 p.
Magan, N., Sanchis, V. and Aldred, D. (2003) The Role of Spoilage Fungi in Seed Deterioration. Marcel Dekker, Inc., New York.
Enyiukwu, D.N., Awurum, A.N. and Nwaneri, J.A. (2014) Mycotoxins in Stored Agricultural Products: Implications to Food Safety and Health and Prospects of Plant-Derived Pesticides as Novel Approach to Their Management. Greener Journal of Microbiology and Antimicrobials, 2, 32-48.
Yvv, A.K. (2016) Mycotoxin Strategies: Impact on Global Health and Wealth. Pharmaceutica Analytica Acta, 7, 1-11.
Missmer, S.A., et al. (2006) Exposure to Fumonisins and the Occurrence of Neutral Tube Defects along the Texas-Mexico Border. Environmental Health Perspectives, 114, 237-241. https://doi.org/10.1289/ehp.8221
CAST (1989) Mycotoxins: Economic and Health Risks. Report No. 116. Council for Agricultural Science and Technology, Ames, IA.
WHO (2011) Children’s Health and the Environment. 42 p.
Takata, Y., Hidaka, H., Ishida, K. and Kobayashi, T. (2013) Giant Cell Reparative Granuloma of the Temporal Bone Successfully Resected with Preservation of Hearing. The Journal of Laryngology & Otology, 127, 716-720. https://doi.org/10.1017/S002221511300114X
Skovgaard, N. (2002) Evaluation of Certain Mycotoxins in Food. World Health Organization Technical Report Series, 906, 62 p.
Peng, W.X., Marchal, J.L.M. and Van der Poel, A.F.B. (2018) Strategies to Prevent and Reduce Mycotoxins for Compound Feed Manufacturing. Animal Feed Science and Technology, 237, 129-153. https://doi.org/10.1016/j.anifeedsci.2018.01.017
Farouq, O., Noor, S. and Marhaban, M.H. (2008) Some Control Strategies in Agricultural Grain Driers: A Review. Journal of Food Agriculture and Environment, 6, 74-85.
Magan, N. and Evans, P. (2000) Volatiles as an Indicator of Fungal Activity and Differentiation between Species, and the Potential Use of Electronic Nose Technology for Early Detection of Grain Spoilage. Journal of Stored Products Research, 36, 319-340. https://doi.org/10.1016/S0022-474X(99)00057-0
Peraica, M., Domijan, A.M., Jurjević, Ž. and Cvjetković, B. (2002) Prevention of Exposure to Mycotoxins from Food and Feed. Archives of Industrial Hygiene and Toxicology, 53, 229-237.
Shi, H., Stroshine, R.L. and Ileleji, K. (2014) Aflatoxin Reduction in Corn by Cleaning and Sorting. ASABE 2014 Annual International Meeting, 1, 311-321.
Stryken, J. (2003) Cleaning Solutions. World Cem., 2, 5-8.
Iqbal, S.Z., Abdull Razis, A.F., Usman, S., et al. (2021) Variation of Deoxynivalenol Levels in Corn and Its Products Available in Retail Markets of Punjab, Pakistan and Estimation of Risk Assessment. Toxins, 13, Article No. 296.
Sipos, P., et al. (2021) Physical and Chemical Methods for Reduction in Aflatoxin Content of Feed and Food. Toxins, 13, Article No. 204. https://doi.org/10.3390/toxins13030204
Ten Bosch, L., Pfohl, K., Avramidis, G., Wieneke, S., Viöl, W. and Karlovsky, P. (2017) Plasma-Based Degradation of Mycotoxins Produced by Fusarium, Aspergillus and Alternaria Species. Toxins, 9, Article No. 97. https://doi.org/10.3390/toxins9030097
Whitlow, L. (2006) Evaluation of Mycotoxin Binders. Proceedings of the 4th Mid-Atlantic Nutrition Conference, Baltimore, 29-30 March 2006, 132-143. http://manc.umd.edu/documents/2006_complete_proceedings.pdf#page=138
Ullah, H.A., et al. (2016) Dietary Mycotoxins Binders: A Strategy to Reduce Aflatoxin m1 Residues and Improve Milk Quality of Lactating Beetal Goats. Journal für Verbraucherschutz und Lebensmittelsicherheit, 11, 305-309. https://doi.org/10.1007/s00003-016-1046-0
De Mil, T., et al. (2015) Characterization of 27 Mycotoxin Binders and the Relation with in Vitro Zearalenone Adsorption at a Single Concentration. Toxins (Basel), 7, 21-33.
Zachetti, V.G.L., Cendoya, E., Nichea, M.J., Chulze, S.N. and Ramirez, M.L. (2019) Preliminary Study on the Use of Chitosan as an Eco-Friendly Alternative to Control Fusarium Growth and Mycotoxin Production on Maize and Wheat. Pathogens, 8, Article No. 29. https://doi.org/10.3390/pathogens8010029
Mart, K., et al. (time) The Effect of Edible Chitosan Coatings Incorporated with Thymus capitatus Essential Oil on the Shelf-Life of Strawberry (Fragaria x ananassa) during Cold Storage. Biomolecules, 8, Article No. 155.
Soares, C., et al. (2020) Use of IoT to Real-Time Monitoring of Storage Silo and Ozone Gas Fungal Decontamination Strategy. International Journal of Computers and Applications, 175, 1-7.
Zhuang, K., et al. (2020) Effect of Different Ozone Treatments on the Degradation of Deoxynivalenol and Flour Quality in Fusarium-Contaminated Wheat. CyTA-Journal of Food, 18, 776-784. https://doi.org/10.1080/19476337.2020.1849406
Wang, L., et al. (2016) Effect of Ozone Treatment on Deoxynivalenol and Wheat Quality. PLoS ONE, 11, e0147613. https://doi.org/10.1371/journal.pone.0147613
Li, M., Guan, E. and Bian, K. (2019) Structure Elucidation and Toxicity Analysis of the Degradation Products of Deoxynivalenol by Gaseous Ozone. Toxins, 11, Article No. 474. https://doi.org/10.3390/toxins11080474
Wang, L., et al. (2019) Aflatoxin B1 Degradation and Detoxification by Escherichia Coli CG1061 Isolated from Chicken Cecum. Frontiers in Pharmacology, 9, Article ID: 1548. https://doi.org/10.3389/fphar.2018.01548
Nešić, K., Habschied, K. and Mastanjević, K. (2021) Possibilities for the Biological Control of Mycotoxins in Food and Feed. Toxins, 13, Article No. 198. https://doi.org/10.3390/toxins13030198
Majumdar, R., Kandel, S.L., Cary, J.W. and Rajasekaran, K. (2021) Changes in Bacterial Endophyte Community Following Aspergillus flavus Infection in Resistant and Susceptible Maize Kernels. International Journal of Molecular Sciences, 22, Article ID: 3747. https://doi.org/10.3390/ijms22073747
Tilocca, B., Balmas, V., Hassan, Z.U., Jaoua, S. and Migheli, Q. (2019) A Proteomic Investigation of Aspergillus carbonarius Exposed to Yeast Volatilome or to Its Major Component 2-Phenylethanol Reveals Major Shifts in Fungal Metabolism. International Journal of Food Microbiology, 306, Article ID: 108265. https://doi.org/10.1016/j.ijfoodmicro.2019.108265
Mendieta, C.R., Gomez Verduzco, G., Del Río, J.C.G., Cuevas, A.C., Arce, J.M. and ávila, E.G. (2018) Effect of the Addition of Saccharomyces cerevisiae Yeast Cell Walls to Diets with Mycotoxins on the Performance and Immune Responses of Broilers. The Journal of Poultry Science, 55, 38-46.
Zhang, Z., Li, M., Wu, C. and Peng, B. (2019) Physical Adsorption of Patulin by Saccharomyces cerevisiae during Fermentation. Journal of Food Science and Technology, 56, 2326-2331. https://doi.org/10.1007/s13197-019-03681-1
Jakopović, Ž., et al. (2018) Properties and Fermentation Activity of Industrial Yeasts Saccharomyces cerevisiae, S. uvarum, Candida Utilis and Kluyveromyces marxianus Exposed to AFB1, OTA and ZEA. Food Technology and Biotechnology, 56, 208-217. https://doi.org/10.17113/ftb.56.02.18.5582
Alberts, J.F., Lilly, M., Rheeder, J.P., Burger, H.M., Shephard, G.S. and Gelderblom, W.C.A. (2017) Technological and Community-Based Methods to Reduce Mycotoxin Exposure. Food Control, 73, 101-109. https://doi.org/10.1016/j.foodcont.2016.05.029
Sarrocco, S., Mauro, A. and Battilani, P. (2019) Use of Competitive Filamentous Fungi as an Alternative Approach for Mycotoxin Risk Reduction in Staple Cereals: State of Art and Future Perspectives. Toxins, 11, Article No. 701. https://doi.org/10.3390/toxins11120701
Lyagin, I. and Efremenko, E. (2019) Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action. Molecules, 24, Article ID: 2362.
Lyagin, I. and Efremenko, E. (2019) Enzymes for Detoxification of Various Mycotoxins. 1-39.
Shanakhat, H., Sorrentino, A., Raiola, A., Romano, A., Masi, P. and Cavella, S. (2018) Current Methods for Mycotoxins Analysis and Innovative Strategies for Their Reduction in Cereals: An Overview. Journal of the Science of Food and Agriculture, 98, 4003-4013. https://doi.org/10.1002/jsfa.8933
Pitt, J.I., et al. (2012) Economics of Mycotoxins: Evaluating Costs to Society and Cost-Effectiveness of Interventions. IARC Scientific Publications, Lyon, 119-129. http://www.ncbi.nlm.nih.gov/pubmed/23477200
Bhat, R. and Vasanthi, S. (1999) Occurrence of Aflatoxin and Its Economic Impact on Human Nutrition and Animal Feed Natural Occurrence. Agriculture et développement, No. 23, 3 p.
Gbashi, S., et al. (2019) The Socio-Economic Impact of Mycotoxin Contamination in Africa. Mycotoxins—Impact and Management Strategies. https://doi.org/10.5772/intechopen.79328