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MtsR, an Iron-Dependent Regulator in <i>Streptococcus iniae</i>
Translational Neuroscience and Neural Regeneration and Repair Institute, The People’s Hospital of China Three Gorges University, Yichang, China
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Medical College, China Three Gorges University, Yichang, China
Translational Neuroscience and Neural Regeneration and Repair Institute, The People’s Hospital of China Three Gorges University, Yichang, China
The Institute of Infection and Inflammation, Medical College, China Three Gorges University, Yichang, China
- 1 Translational Neuroscience and Neural Regeneration and Repair Institute, The People’s Hospital of China Three Gorges University, Yichang, China
- 2 Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Medical College, China Three Gorges University, Yichang, China
- 3 Translational Neuroscience and Neural Regeneration and Repair Institute, The People’s Hospital of China Three Gorges University, Yichang, China
- 4 The Institute of Infection and Inflammation, Medical College, China Three Gorges University, Yichang, China
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Abstract
Streptococcus iniae ( S. iniae ) is a major pathogen that is capable of resulting severe economic loss to cultured fish. Steadily iron availability from micro-environment is an important virulence factor for pathogens, and S. iniae encodes the iron-transporter MtsABC to accomplish heme utilization, but very little was known about the mechanisms involved in regulating and maintaining iron balance in S. iniae . In this study, the role of a putative iron-dependent transcriptional regulator MtsR was investigated, and the results showed that MtsR regulated the expression of iron-transport mtsABC to control iron homeostasis in S. iniae .
Keywords<i>Streptococcus iniae</i>Iron-Dependent RegulatorIron TransporterMtsRMtsABC
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