Study on Molecular Mechanism of Yiqing Capsule in Treating Upper Respiratory Tract Infection Based on Network Pharmacology
- 1 Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde, China
- 2 Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde, China
Abstract
Objective: To investigate the possible mechanism of Yiqing Capsules in the treatment of upper respiratory tract infection based on network pharmacology. Methods: The main active components of Yiqing Capsules were selected on TCMSP database; the targets of upper respiratory tract infection were selected on GeneCards database. The drug-compound-target network and PPi network were constructed through STRING database and soft Cytoscape 3.7.2. Soft R was used to perform GO enrichment analysis and KEGG pathway enrichment analysis of main targets. Results : According to the screening conditions, 48 active compounds and 171 related targets were obtained. GO enrichment analysis obtained 2333 items, KEGG pathway enrichment analy sis obtained 2248 items, including Kaposi sarcoma-associated herpesvirus infection, Human cytomegalovirus infection, Epstein-Barr virus infection, PI3K-Akt signaling pathway, etc. Conclusion : Yiqing capsules play a therapeutic role in upper respiratory tract infection through multi-target and multi-pathway.
- Ding, H., Yan, B., Tian, L., et al. (2011) A Mutli-Center Randomized Double-Blind Controlled Trial on the Function of Yiqing Capsule Treat. Liaoning Journal of Traditional Chinese Medicine, 38, 1468-1490.
- Liu, X. (2017) Study on the Effect of Chronic Pharyngitis Mixture on Chronic Pharyngitis. Medical Innovation of China, 14, 112-114.
- Zhang, Y. and Wang, Y. (2016) Observation of Yiqing Capsule Combined with Antibiotic in the Treatment of 118 Cases of Acute Pharyngitis. Nei Mongol Journal of Traditional Chinese Medicine, 2, 74-75.
- Zhang, L. (2018) Analysis of the Efficacy of Yiqing Capsule Combined with Meifeng in Treating Chronic Pharyngitis. Clinical Research, 26, 118-120.
- Jiang, R. and Zhang, C. (2010) Clinical Observat Ion on 72 Cases of Acne Vulgaris Treated by Yiqing Capsule. Journal of Traditional Chinese Medicine, 51, 996-998.
- Liu, C., Xie, B., Cai, L., et al. (2018) Clinical Study on Yiqing Capsules Combined with Minocycline in Treatment of Chronic Periodontitis. Drugs & Clinic, 33, 2083-2086.
- Hou, Y., Liu, X. and Xu, Q. (2001) Clinical Observation of 156 Cases of Acute Upper Respiratory Tract Infection Treated by Yiqing Capsule and Antibiotics. West China Journal of Pharmaceutical Sciences, 16, 401.
- Liu, W. (2018) Levels and Clinical Significances of Serum 25-Hydroxyvitamin D3, IL-10 and IL-17 in Children with Recurrent Upper Respiratory Infection. China Medical Herald, 15, 80-83.