To Explore the Potential Mechanism of Yiqing Capsule in the Treatment of COVID-19 Based on Network Pharmacology
- 1 Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde, China
- 2 Department of Functional Center, Chengde Medical College, Chengde, China
- 3 Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde, China
- 4 Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde, China
- 5 Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde, China
- 6 Department of Pharmacy, The Affiliated Hospital of Chengde Medical College, Chengde, China
Abstract
Objective: To select the ingredients and targets of Yiqing capsule in treating COVID-19 based on network pharmacology, then to explore the potential mechanism of Yiqing capsule in treating COVID-19. Methods: We screened the ingredients and targets of Yiqing capsule on Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and target genes for COVID-19 in GeneCards database , constructed drug-ingredient-target network through software Cytoscape 3.7.2 , and constructed protein protein interaction network (PPI) network through STRING database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of key gene targets of Yiqing capsule are used to treat COVID-19 through software R5.3.2. Results : We got 42 ingredients, 42 potential therapeutic targets, 1643 GO items and 970 pathways in our study. The main pathway including IL-17 signaling pathway, Chagas disease (American trypanosomiasis), Influenza A, and TNF signaling pathway. Conclusion : Yiqing capsule plays a role in treating COVID-19 through multiple ingredients, multiple targets and multiple pathways.
- Sohrabi, C., Alsafi, Z., O’Neill, N., et al. (2020) World Health Organization Declares Global Emergency: A Review of the 2019 Novel Coronavirus (COVID-19). International Journal of Surgery, 76, 71-76. https://doi.org/10.1016/j.ijsu.2020.02.034
- Ma, J.J., Chen, M. and Wang, Y.G. (2020) Novel Coronavirus (2019-ncov) Syndrome: A Review of TCM Syndrome Treatment. Beijing Journal of Traditional Chinese Medicine, 39, 95-101.
- Sun, Z.T., An, X., Xiao, W., et al. (2020) Discussion on Differentiation and Treatment of COVID-19 by Stages. Journal of Shaanxi University of Chinese Medicine. http://kns.cnki.net/kcms/detail/61.1501.R.20200211.1318.002.html
- Xu, L.H., Li, Y.R., Zheng, D.R., et al. (2020) To Explore Prescription Law of New Coronavirus Pneumonia in Different Stages Based on “Appropriate Measures in Different Time”. Chinese Journal of Experimental Traditional Medical Formulae. http://kns.cnki.net/kcms/detail/11.3495.R.20200225.1145.003.html
- Ding, H., Yan, B.H., Tian, L., et al. (2011) A Mutli-Center Randomized Double-Blind Controlled Trial on the Function of Yiqing Capsule Treat. Liaoning Journal of Traditional Chinese Medicine, 38, 1468-1490.
- Hou, Y.L., Liu, X.M. and Xu, Q. (2001) Clinical Observation of 156 Cases of Acute Upper Respiratory Tract Infection Treated by Yiqing Capsule and Antibiotics. West China Journal of Pharmaceutical Sciences, 16, 401.
- Xu, X.L., Yue, Y., Liu, X.J., et al. (2015) Anti-Virus Effect of Yiqing Capsule on Influenza A Subtype H1N1. The Chinese Journal of Modern Applied Pharmacy, 32, 1056-1058.
- Liu, C.H. and Wang, Y. (2020) Discussion on the Application of Febrile Disease Theory to the Diagnosis and Treatment of COVID-19. SH. J. Traditional Chinese Medicine, 54, 5-8.
- Zheng, W.K., Zhang, J.H., Yang, F.W., et al. (2020) Comprehensive Analysis of Diagnosis and Treatment Schemes for Prevention and Treatment of Novel Coronavirus Pneumonia by Traditional Chinese Medicine. Journal of Traditional Chinese Medicine, 61, 277-280.
- Xu, L.H., Huang, X.J., Li, Y.R., et al. ()2020 Effect and Potential Mechanism of Rhubarb on COVID-19 Based on the “Wenbingzaixiaqiyure” Theory. Pharmacology and Clinics of Chinese Materia Medica. http://kns.cnki.net/kcms/detail/51.1188.R.20200330.1038.002.html
- Huang, L.L., Wang, J.N., Xu, R., et al. (2020) Study on Mechanism of HuanglianJiedu Decoction in Treating Novel Coronavirus Pneumonia Based on Network Pharmacology. http://kns.cnki.net/kcms/detail/44.1286.r.20200326.1642.054.htm