RETRACTED:Exploring the Mechanism of Wu Ling San plus Flavor for the Treatment of Diabetic Macular Edema Based on Network Pharmacology and Molecular Docking Techniques — Oak Academic Publishing
Research ArticleOpen AccessGoogle Scholar indexed
RETRACTED:Exploring the Mechanism of Wu Ling San plus Flavor for the Treatment of Diabetic Macular Edema Based on Network Pharmacology and Molecular Docking Techniques
Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China
,
Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
,
Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
,
Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
,
Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
,
Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
,
Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
,
Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
1 Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China
2 Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
3 Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
4 Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
5 Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
6 Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
7 Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
8 Department of Ophthalmology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China
Short Retraction Notice The paper does not meet the standards of “Chinese Medicine ". This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines . The a im is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused. Editor guiding this retraction: Prof. Maythem Saeed (EiC of CM ) The full retraction notice in PDF is preceding the original paper, which is marked "RETRACTED".
KeywordsDiabetic Macular EdemaDiabetic RetinopathyWu Ling San plus FlavorAlkaloidsAliphaticNetwork PharmacologyMolecular Docking
Wong, T.Y., Sun, J., Kawasaki, R., et al. (2018) Guidelines on Diabetic Eye Care: The International Council of Ophthalmology Recommendations for Screening, Follow-Up, Referral, and Treatment Based on Resource Settings. Ophthalmology, 125, 1608-1622. https://doi.org/10.1016/j.ophtha.2018.04.007
Das, A., McGuire, P.G. and Rangasamy, S. (2015) Diabetic Macular Edema: Pathophysiology and Novel Therapeutic Targets. Ophthalmology, 122, 1375-1394. https://doi.org/10.1016/j.ophtha.2015.03.024
Gu, H.R. and Jia, C.H. (2011) Analysis of Wulingsan Prescription. Journal of Shandong University of Traditional Chinese Medicine, 35, 208-209.
Hu, Z., Xie, C., Yang, M., et al. (2021) Add-On Effect of Qiming Granule, a Chinese Patent Medicine, in Treating Diabetic Macular Edema: A Systematic Review and Meta-Analysis. Phytotherapy Research, 35, 587-602. https://doi.org/10.1002/ptr.6844
Fu, Y.Y., Liu, Q.F. and Pu, Z.X. (2007) Clinical Study of Chronic Glomerulonephritis Proteinuria. Journal of Changchun University of Traditional Chinese Medicine, No. 1, 42.
State Administration of Traditional Chinese Medicine (1994) Diagnostic and Therapeutic Standards for Chinese Medicine. Journal of Chinese Medicine Management, No. 6, 2.
Hopkins, A.L. (2008) Network Pharmacology: The Next Paradigm in Drug Discovery. Nature Chemical Biology, 4, 682-690. https://doi.org/10.1038/nchembio.118
Zhang, Y.Q. and Li, S. (2015) Some Advances in Network Pharmacology and Modern Research of Traditional Chinese Medicine. Chinese Journal of Pharmacology and Toxicology, 29, 883-892.
Goh, K.I., Cusick, M.E., Valle, D., Childs, B., Vidal, M. and Barabási, A.L. (2007) The Human Disease Network. Proceedings of the National Academy of Sciences of the United States of America, 104, 8685-8690. https://doi.org/10.1073/pnas.0701361104
Liu, Z.H. and Sun, X.B. (2012) Network Pharmacology: New Opportunity for the Modernization of Traditional Chinese Medicine. Acta Pharmaceutica Sinica, 47, 696-703.
Xue, L.C., Dobbs, D., Bonvin, A.M. and Honavar, V. (2015) Computational Prediction of Protein Interfaces: A Review of Data Driven Methods. FEBS Letters, 589, 3516-3526. https://doi.org/10.1016/j.febslet.2015.10.003
Villoutreix, B.O., Bastard, K., Sperandio, O., et al. (2008) In Silico-In Vitro Screening of Protein-Protein Interactions: Towards the Next Generation of Therapeutics. Current Pharmaceutical Biotechnology, 9, 103-122. https://doi.org/10.2174/138920108783955218
Vakser, I.A. (2014) Protein-Protein Docking: From Interaction to Interactome. Biophysical Journal, 107, 1785-1793. https://doi.org/10.1016/j.bpj.2014.08.033
Ru, J., Li, P., Wang, J., et al. (2014) TCMSP: A Database of Systems Pharmacology for Drug Discovery from Herbal Medicines. Journal of Cheminformatics, 6, Article No. 13. https://doi.org/10.1186/1758-2946-6-13
Jeong, H., Mason, S.P., Barabási, A.L. and Oltvai, Z.N. (2001) Lethality and Centrality in Protein Networks. Nature, 411, 41-42. https://doi.org/10.1038/35075138
Trott, O. and Olson, A.J. (2010) AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading. Journal of Computational Chemistry, 31, 455-461. https://doi.org/10.1002/jcc.21334
Zhang, Q., Xu, Y., Peng, W., et al. (2020) To Study the Molecular Mechanism of Guizhi Shaoyao Zhimu Decoction in the Treatment of Rheumatoid Arthritis by Molecular Docking and Network Pharmacology. Chinese Herbal Medicine, 51, 4673-4684.
Zhu, N., Sha, Z.J., He, J.W., et al. (2020) Discovery and Study of the Potential Value of Uncaria Eucommia Drugs in the Treatment of Pregnancy Hypertension Based on Network Pharmacology and Molecular Docking. China Journal of Chinese Materia Medica, 45, 5393-5402.
Zhou, M.L., Huang, X.Y., Chen, Y.L., et al. (2020) To Explore the Mechanism and Experimental Verification of Sijunzi Decoction in the Treatment of Ulcerative Colitis Based on Network Pharmacology. China Journal of Chinese Materia Medica, 45, 5362-5372.
Wang, H.Z., Gao, G., Yang, Q.Q., et al. (2020) To Explore the Therapeutic Mechanism of Rehmannia officinalis and Corni officinalis on Sequelae Stage of Ischemic Stroke Based on Network Pharmacology Technology. China Journal of Chinese Materia Medica, 45, 6020-6027.
Bungau, S., Abdel-Daim, M.M., Tit, D.M., et al. (2019) Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases. Oxidative Medicine and Cellular Longevity, 2019, Article ID: 9783429. https://doi.org/10.1155/2019/9783429
Arikan, S., Ersan, I., Karaca, T., et al. (2015) Quercetin Protects the Retina by Reducing Apoptosis Due to Ischemia-Reperfusion Injury in a Rat Model. Arquivos Brasileiros de Oftalmologia, 78, 100-104. https://doi.org/10.5935/0004-2749.20150026
Lupo, G., Cambria, M.T., Olivieri, M., et al. (2019) Anti-Angiogenic Effect of Quercetin and Its 8-methyl Pentamethyl Ether Derivative in Human Microvascular Endothelial Cells. Journal of Cellular and Molecular Medicine, 23, 6565-6577. https://doi.org/10.1111/jcmm.14455
Ola, M.S., Ahmed, M.M., Shams, S. and Al-Rejaie, S.S. (2017) Neuroprotective Effects of Quercetin in Diabetic Rat Retina. Saudi Journal of Biological Sciences, 24, 1186-1194. https://doi.org/10.1016/j.sjbs.2016.11.017
Zhao, L., Sun, J., Shi, S., Qin, X., Zhang, K. and Xu, J. (2020) Kaempferol Protects Retinal Ganglion Ceils from High-Glucose-Induced Injury by Regulating Vasohibin-1. Neuroscience Letters, 716, Article ID: 134633. https://doi.org/10.1016/j.neulet.2019.134633
Xu, X.H., Zhao, C., Peng, Q., Xie, P. and Liu, Q.H. (2017) Kaempferol Inhibited VEGF and PGF Expression and in Vitro Angiogenesis of HRECs under Diabetic-Like Environment. Brazilian Journal of Medical and Biological Research, 50, e5396. https://doi.org/10.1590/1414-431x20165396
Tarantino, G. and Caputi, A. (2011) JNKs, Insulin Resistance and Inflammation: A Possible Link between NAFLD and Coronary Artery Disease. World Journal of Gastroenterology, 17, 3785-3794. https://doi.org/10.3748/wjg.v17.i33.3785
Chen, F. (2012) JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells. Cancer Research, 72, 379-386. https://doi.org/10.1158/0008-5472.CAN-11-1982
Su, C.C., Chen, J.Y., Din, Z.H., et al. (2014) 13-Acetoxysarcocrassolide Induces Apoptosis on Human Gastric Carcinoma Cells through Mitochondria-Related Apoptotic Pathways: p38/JNK Activation and PI3K/AKT Suppression. Marine Drugs, 12, 5295-5315. https://doi.org/10.3390/md12105295
Cade, W.T. (2008) Diabetes-Related Microvascular and Macrovascular Diseases in the Physical Therapy Setting. Physical Therapy, 88, 1322-1335. https://doi.org/10.2522/ptj.20080008
Bonnefont-Rousselot, D. (2002) Glucose and Reactive Oxygen Species. Current Opinion in Clinical Nutrition & Metabolic Care, 5, 561-568. https://doi.org/10.1097/00075197-200209000-00016
Behl, T., Kaur, I. and Kotwani, A. (2016) Implication of Oxidative Stress in Progression of Diabetic Retinopathy. Survey of Ophthalmology, 61, 187-196. https://doi.org/10.1016/j.survophthal.2015.06.001
Kwon, J.W. and Jee, D. (2018) Aqueous Humor Cytokine Levels in Patients with Diabetic Macular Edema Refractory to Anti-VEGF Treatment. PLOS ONE, 13, e0203408. https://doi.org/10.1371/journal.pone.0203408
Noma, H., Yasuda, K. and Shimura, M. (2021) Involvement of Cytokines in the Pathogenesis of Diabetic Macular Edema. International Journal of Molecular Sciences, 22, 3427. https://doi.org/10.3390/ijms22073427
Vinores, S.A., Derevjanik, N.L., Ozaki, H., Okamoto, N. and Campochiaro, P.A. (1999) Cellular Mechanisms of Blood-Retinal Barrier Dysfunction in Macular Edema. Documenta Ophthalmologica, 97, 217-228. https://doi.org/10.1023/A:1002136712070
Fletcher, E.L., Phipps, J.A., Ward, M.M., Puthussery, T. and Wilkinson-Berka, J.L. (2007) Neuronal and Glial Cell Abnormality as Predictors of Progression of Diabetic Retinopathy. Current Pharmaceutical Design, 13, 2699-2712. https://doi.org/10.2174/138161207781662920
Zong, H., Ward, M., Madden, A., Yong, P.H., et al. (2010) Hyperglycaemia-Induced Pro-Inflammatory Responses by Retinal Müller Glia Are Regulated by the Receptor for Advanced Glycation End-Products (RAGE). Diabetologia, 53, 2656-2666. https://doi.org/10.1007/s00125-010-1900-z
Starace, V., Battista, M., Brambati, M., et al. (2021) The Role of Inflammation and Neurodegeneration in Diabetic Macular Edema. Therapeutic Advances in Ophthalmology, 13. https://doi.org/10.1177/25158414211055963
Chung, Y.R., Kim, Y.H., Ha, S.J., et al. (2019) Role of Inflammation in Classification of Diabetic Macular Edema by Optical Coherence Tomography. Journal of Diabetes Research, 2019, Article ID: 8164250. https://doi.org/10.1155/2019/8164250